Programas de prevención del abuso sexual en personas con discapacidad intelectual y del desarrollo

Las personas con discapacidad intelectual y del desarrollo, particularmente las mujeres, son especialmente vulnerables a las situaciones de abuso sexual. El objetivo principal de esta revisión es examinar los estudios empíricos sobre la efectividad de programas de prevención del abuso sexual en esta población. Una búsqueda sistemática en PsycINFO, Web of Science y Psicodoc, identificó diez estudios publicados sobre el tema. Los resultados obtenidos muestran que la mayoría de los programas de prevención están basados en la adquisición de habilidades conductuales y que hay otros centrados en la educación sexual. Aunque existen datos que demuestran la efectividad, sobre todo, de los programas de habilidades, la mayoría de los estudios no ofrecen resultados robustos con los que juzgar la efectividad de estas intervenciones. Las conclusiones de la revisión se centran en la necesidad de aumentar la investigación sobre la población con discapacidad intelectual y del desarrollo, especialmente en mujeres y en el ámbito del abuso sexual

La sustancia de la representación: esencia y significado

Catálogo de la exposición colectiva celebrada en la sala de exposiciones de la Facultad de Bellas Artes de la Universidad Complutense de Madrid entre el 5 y el 20 de marzo de 2018. La exposición denominada “LA SUSTANCIA DE LA REPRESENTACIÓN. ESENCIA Y SIGNIFICADO” tiene como objetivo mostrar las obras más relevantes y personales de treinta y tres artistas pertenecientes a la facultad de Bellas Artes de la Universidad Complutense de Madrid. Comisariada por Mauro Hernández, Sandra Malvar y Rodrigo Moreno

Programas de prevención del abuso sexual en personas con discapacidad intelectual y del desarrollo

People with intellectual and developmental disabilities, especially women, are particularly vulnerable to situations of sexual abuse. The aim of this review is to examine empirical studies on the effectiveness of sexual abuse prevention programs for this population. A systematic search on PsycINFO, Web of Science and Psicodoc identified ten published studies on the subject. The results obtained show that most prevention programs are based on the acquisition of behavioral abilities whereas others are based on sexual education. Although there are some data that demonstrate the effectiveness, particularly, of those programs based on abilities, the majority of studies do not provide robust evidence to judge the effectiveness of these interventions. The conclusions of the review are focused on the need to increase research about population with intellectual and developmental disabilities, especially in women, and the area of sexual abuse.Las personas con discapacidad intelectual y del desarrollo, particularmente las mujeres, son especialmente vulnerables a las situaciones de abuso sexual. El objetivo principal de esta revisión es examinar los estudios empíricos sobre la efectividad de programas de prevención del abuso sexual en esta población. Una búsqueda sistemática en PsycINFO, Web of Science y Psicodoc, identificó diez estudios publicados sobre el tema. Los resultados obtenidos muestran que la mayoría de los programas de prevención están basados en la adquisición de habilidades conductuales y que hay otros centrados en la educación sexual. Aunque existen datos que demuestran la efectividad, sobre todo, de los programas de habilidades, la mayoría de los estudios no ofrecen resultados robustos con los que juzgar la efectividad de estas intervenciones. Las conclusiones de la revisión se centran en la necesidad de aumentar la investigación sobre la población con discapacidad intelectual y del desarrollo, especialmente en mujeres y en el ámbito del abuso sexual

Sexual abuse prevention programs for people with intellectual and developmental disabilities: A systematic review

Las personas con discapacidad intelectual y del desarrollo, particularmente las mujeres, son especialmente vulnerables a las situaciones de abuso sexual. El objetivo principal de esta revisión es examinar los estudios empíricos sobre la efectividad de programas de prevención del abuso sexual en esta población. Una búsqueda sistemática en PsycINFO, Web of Science y Psicodoc, identificó diez estudios publicados sobre el tema. Los resultados obtenidos muestran que la mayoría de los programas de prevención están basados en la adquisición de habilidades conductuales y que hay otros centrados en la educación sexual. Aunque existen datos que demuestran la efectividad, sobre todo, de los programas de habilidades, la mayoría de los estudios no ofrecen resultados robustos con los que juzgar la efectividad de estas intervenciones. Las conclusiones de la revisión se centran en la necesidad de aumentar la investigación sobre la población con discapacidad intelectual y del desarrollo, especialmente en mujeres y en el ámbito del abuso sexual

Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma.

Asthma is a chronic inflammatory disease characterized by bronchial hyperresponsiveness, mucus overproduction and airway remodeling. Notably, we have recently demonstrated that insulin-like growth factor 1 receptor (IGF1R) deficiency in mice attenuates airway hyperresponsiveness and mucus secretion after chronic house dust mite (HDM) exposure. On this basis, inbred C57BL/6 and Igf1r-deficient mice were given HDM extract to study the acute inflammatory profile and implication of Igf1r in acute asthma pathobiology. Additionally, Igf1r-deficiency was therapeutically induced in mice to evaluate the resolution of HDM-induced inflammation. Acute HDM exposure in inbred C57BL/6 mice led to a progressive increase in inflammation, airway remodeling and associated molecular indicators. Preventively-induced Igf1r-deficiency showed reduced neutrophil and eosinophil numbers in BALF and bone marrow, a significant reduction of airway remodeling and decreased levels of related markers. In addition, therapeutic targeting of Igf1r promoted the resolution of HDM-induced-inflammation. Our results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM-induced inflammation. Thus, IGF1R is suggested to be a promising candidate for future therapeutic approaches for the treatment and prevention of asthma

Thyroid Function and Thyroid Autoimmunity in Relation to Weight Status and Cardiovascular Risk Factors in Children and Adolescents: A Population-Based Study.

In obese subjects, slight increases have been observed in thyrotropin [thyroid-stimulating hormone (TSH)] levels, but data in children are scarce. The aim of this study was to evaluate whether thyroid function and autoimmunity vary with weight status in a healthy population of children and adolescents and to determine whether hyperthyrotropinemia is associated with any cardiovascular risk factor. This cross-sectional epidemiological study was conducted in Almería (Spain) on a representative sample of 1317 healthy subjects aged 2-16 years. Thyroid function, thyroid autoimmunity and cardiovascular risk factors were measured. Chi-square test, analysis of variance and multiple linear regression were used in the statistical analyses. The obese children and adolescents had thyrotropin levels (mean ± standard deviation) of 3.12±2.44 mU/L. These levels were higher than those of overweight subjects (2.79±1.51 mU/L) and of normal weight subjects (2.73±1.30 mU/L) (p=0.02). Levels of free thyroxine and urinary iodine did not differ significantly between the groups. The prevalence (95% confidence interval) of thyroid autoimmunity was lower in the individuals with normal weight (2.9%; 2.0-4.2) than in the overweight (6.3%; 3.9-9.9) and obese subjects (5.6%, 2.5-11.3) (p=0.02). TSH levels were associated with obesity (β=0.36; p Obese children and adolescents had higher levels of thyrotropin than those who were overweight and of normal weight. The differences among the groups were of very little clinical significance and could possibly be linked to the higher prevalence of thyroid autoimmunity in obese subjects. The hyperthyrotropinemia in these subjects was not associated with any cardiovascular risk factor

Cytolocalyzation and cytotoxicity of new luminescent cyclometalated platinum(II) complexes: use as organelle biomarkers and antitumoral drugs with potential in photodynamic therapy

Two series of luminescent cyclometalated Pt(II) com-plexes were synthesized a nd their biological activitywas assessed. One was based on the deprotonated do-nor-acceptor 2-(4-dimethylaminephenyl)benzothiazoleligand (NMe 2 -pbt) and includes four mononuclear com-plexes [Pt(Me2N-pbt)(C6F5 )L] (L = Me2N-pbtH) 1, p-dpbH(4-diphenylphosphino)benzoic acid) 2, o-dpbH (2-diphe-nylphosphino)benzoic acid) [Pt(Me2N-pbt)(C6F5 )(o-dpbH)]3 (unstable), and [Pt(Me2N-pbt)(o-dpb)] 4, as well as oftwo binuclear derivatives [{Pt(Me2N-pbt)(C6F5 )}2(m-PRnP)][PR4 P = O(CH2CH2OC(O)C6H 4PPh 2)2 5; PR12P = O{(CH-2CH2O)3C(O)C6H 4PPh 2}2 6]. The second includes 2,6-di-fluorophenylpyridine (dfppy) and phenylquinoline (pq) aschromophores and acyclic diaminocarbene (ADC) ligandsas auxiliary ligands [Pt(C^N)Cl{C(NHXyl)(NHR)}] [C^N =dfppy (a), pq (b); R = Pr 7a, 8a, CH2 Ph 7b, 8b]. In theNMe2-pbt based complexes the phosphorescent emissionis lost in aerated solutions, owing to photoinduced electrontransfer to 3 O2 and formation 1 O2 singlet, as confirmed incomplexes 2 and 4. Here we report some of their biological activity. Cytotoxicity studies in the human cancer celllines A549 (lung carcinoma) and HeLa (cervix carcinoma)showed good activity for the ADC complexes 7 and 8. Tothe best of our knowledge, these compounds representthe first examples of cycloplatinated complexes bearingacyclic diamino carbenes with antiproliferative properties(Ref.). Accordingly, 7a, 7b and 8a altered DNA electropho-retic mobility pointing as a possible cytotoxic mechanism.NMe2-pbt complexes 2, 3 and 6 were also active againstA549 and HeLa cancer cells, with higher efficiency in A549,in contrast to 1, 4, and 5. Cytolocalization studies revealedthat the no cytotoxic ligand Me 2 N-pbtH and their deriva-tive complexes 1-6 exhibit specific accumulation in theGolgi apparatus. Furthermore, the potential photodynamicproperty of this type of complexes was demonstrated withthe non-cytotoxic complex 4, which demonstrated efficientphotoinduced cytotoxicity after irradiation