54 research outputs found
Determine the room for improvement of processes within the management of crisis and their prevention – the maturity mode
Crisis within the meat sector usually causes high economic losses for the affected sector and frequently for other sectors, too. Interrupted or poor communication channels are weak points in management-systems, especially in the management of crisis situations or of the prevention of crisis. In a consequence necessary information for a proper decision making is missing or not available in time
Why Physicians Who Treat Hypertension Should Know More About Air Pollution
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75525/1/j.1524-6175.2007.07187.x.pd
Study of the and reactions close to threshold
Two--kaon production in proton--deuteron collisions has been studied at three
energies close to threshold using a calibrated magnetic spectrograph to measure
the final He and a vertex detector to measure the pair.
Differential and total cross sections are presented for the production of
--mesons, decaying through , as well as for prompt
production. The prompt production seems to follow phase space in both
its differential distributions and in its energy dependence. The amplitude for
the {He} reaction varies little for excess energies below 22
MeV and the value is consistent with that obtained from a threshold
measurement. The angular distribution of the decay pair shows that
near threshold the --mesons are dominantly produced with polarization
along the initial proton direction. No conclusive evidence for
production is found in the data.Comment: 13 figure
Analyzing Powers and Spin Correlation Coefficients for p+d Elastic Scattering at 135 and 200 MeV
The proton and deuteron analyzing powers and 10 of the possible 12 spin
correlation coefficients have been measured for p+d elastic scattering at
proton bombarding energies of 135 and 200 MeV. The results are compared with
Faddeev calculations using two different NN potentials. The qualitative
features of the extensive data set on the spin dependence in p+d elastic
scattering over a wide range of angles presented here are remarkably well
explained by two-nucleon force predictions without inclusion of a three-nucleon
force. The remaining discrepancies are, in general, not alleviated when
theoretical three-nucleon forces are included in the calculations.Comment: 43 pages, 12 figures, accepted for publication by Phys. Rev.
Associations between sub-clinical markers of cardiometabolic risk and exposure to residential indoor air pollutants in healthy adults in Perth, Western Australia: A study protocol
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Background: A growing body of epidemiological and clinical evidence has implicated air pollution as an emerging risk factor for cardiometabolic disease. Whilst individuals spend up to two-thirds of daily time in their domestic residential environment, very few studies have been designed to objectively measure the sub-clinical markers of cardiometabolic risk with exposure to domestic indoor air pollutants. This cross-sectional study aims to investigate associations between the components of domestic indoor air quality and selected sub-clinical cardiometabolic risk factors in a cohort of healthy adults living in Perth,Western Australia. Methods: One hundred and eleven non-smoking adults (65% female) living in non-smoking households who were aged between 35-69 years were recruited for the project. Study subjects were invited to participate in all sections of the study, which included: Domestic indoor air monitoring along with the concurrent 24 h ambulatory monitoring of peripheral and central blood pressure and measures of central hemodynamic indices, standardized questionnaires on aspects relating to current health status and the domestic environment, a 24 h time-activity diary during the monitoring period, and clinic-based health assessment involving collection of blood and urine biomarkers for lipid and glucose profiles, as well as measures of renal function and an analysis of central pulse wave and pulse wave velocity. Results: This study provides a standardized approach to the study of sub-clinical cardiometabolic health effects that are related to the exposure to indoor air pollution. Conclusion: The findings of this study may provide direction for future research that will further contribute to our understanding of the relationship that exists between indoor air pollution and sub-clinical markers of cardiometabolic risk
Experimental study of the pd(d p) → 3 He ππ reactions close to threshold
New experimental data on the pd → 3
He π+π− reaction obtained with the COSY-MOMO detector below
the three-pion threshold are presented. The reaction was also studied in inverse kinematics with a deuteron beam
and the higher counting rates achieved were especially important at low excess energies. The comparison of
these data with inclusive pd → 3
He X0 rates allowed estimates also to be made of π0π0 production. The results
confirm our earlier findings that, close to threshold, there is no enhancement at low excitation energies in the
π+π− system, where the data seem largely suppressed compared with phase space. Possible explanations for
this behavior, such as strong p waves in the π+π− system or the influence of two-step processes, are explored
Gaseous air pollution and emergency hospital visits for hypertension in Beijing, China: a time-stratified case-crossover study
Background: A number of epidemiological studies have been conducted to research the adverse effects of air pollution on mortality and morbidity. Hypertension is the most important risk factor for cardiovascular mortality. However, few previous studies have examined the relationship between gaseous air pollution and morbidity for hypertension. ---------- Methods: Daily data on emergency hospital visits (EHVs) for hypertension were collected from the Peking University Third Hospital. Daily data on gaseous air pollutants (sulfur dioxide (SO2) and nitrogen dioxide (NO2)) and particulate matter less than 10 μm in aerodynamic diameter (PM10) were collected from the Beijing Municipal Environmental Monitoring Center. A time-stratified case-crossover design was conducted to evaluate the relationship between urban gaseous air pollution and EHVs for hypertension. Temperature and relative humidity were controlled for. ---------- Results: In the single air pollutant models, a 10 μg/m3 increase in SO2 and NO2 were significantly associated with EHVs for hypertension. The odds ratios (ORs) were 1.037 (95% confidence interval (CI): 1.004-1.071) for SO2 at lag 0 day, and 1.101 (95% CI: 1.038-1.168) for NO2 at lag 3 day. After controlling for PM10, the ORs associated with SO2 and NO2 were 1.025 (95% CI: 0.987-1.065) and 1.114 (95% CI: 1.037-1.195), respectively.---------- Conclusion: Elevated urban gaseous air pollution was associated with increased EHVs for hypertension in Beijing, China
Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation
<p>Abstract</p> <p>Background</p> <p>The fate of gold nanoparticles, 2, 40 and 100 nm, administered intratracheally to adult female mice was examined. The nanoparticles were traced by autometallography (AMG) at both ultrastructural and light microscopic levels. Also, the gold content was quantified by inductively coupled plasma mass spectrometry (ICP-MS) and neutron activation analysis (NAA). The liver is the major site of deposition of circulating gold nanoparticles. Therefore the degree of translocation was determined by the hepatic deposition of gold. Mice were instilled with 5 intratracheal doses of gold nanoparticles distributed over a period of 3 weeks and were killed 24 h after the last dose. One group of mice were given a single intratracheal dose and were killed after 1 h.</p> <p>Results</p> <p>The instilled nanoparticles were found in lung macrophages already 1 h after a single instillation. In mice instilled treated repeatedly during 3 weeks, the load was substantial. Ultrastructurally, AMG silver enhanced gold nanoparticles were found in lysosome-/endosome-like organelles of the macrophages and analysis with AMG, ICP-MS and NAA of the liver revealed an almost total lack of translocation of nanoparticles. In mice given repeated instillations of 2 nm gold nanoparticles, 1.4‰ (by ICP-MS) to 1.9‰ (by NAA) of the instilled gold was detected in the liver. With the 40 nm gold, no gold was detected in the liver (detection level 2 ng, 0.1‰) except for one mouse in which 3‰ of the instilled gold was found in the liver. No gold was detected in any liver of mice instilled with 100 nm gold (detection level 2 ng, 0.1‰) except in a single animal with 0.39‰ of the dose in the liver.</p> <p>Conclusion</p> <p>We found that that: (1) inert gold nanoparticles, administered intratracheally are phagocytosed by lung macrophages; (2) only a tiny fraction of the gold particles is translocated into systemic circulation. (3) The translocation rate was greatest with the 2 nm gold particles.</p
Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis
Air pollution has been associated with significant adverse health effects leading to increased overall morbidity and mortality of worldwide significance. Epidemiological studies have shown that the largest portion of air pollution-related mortality is due to cardiovascular diseases, predominantly those of ischemic nature. Human studies suggest an association with atherosclerosis and increasing experimental animal data support that this association is likely to be causal. While both gasses and particles have been linked to detrimental health effects, more evidence implicates the particulate matter (PM) components as major responsible for a large portion of the proatherogenic effects. Multiple experimental approaches have revealed the ability of PM components to trigger and/or enhance free radical reactions in cells and tissues, both ex vivo as well as in vivo. It appears that exposure to PM leads to the development of systemic prooxidant and proinflammatory effects that may be of great importance in the development of atherosclerotic lesions. This article reviews the epidemiological studies, experimental animal, and cellular data that support the association of air pollutants, especially the particulate components, with systemic oxidative stress, inflammation, and atherosclerosis. It also reviews the use of transcriptomic studies to elucidate molecular pathways of importance in those systemic effects
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