Morphological differentiation of sympatric species of the genus Helcogrammoides in Chile

Indexación: Scopus; Scielo.Castillo & Pequeño (1998) dealt with the morphological differences between the species of Helcogrammoides genus, however, the distribution of the characters may obscure the quality of the diagnosis; therefore, to evaluate the morphological characters (morphometric and meristic) through multivariate and univariate statistical analysis can help in the description and morphological identification of the species. Here, we performed morphological analyses to improve the characterization of Helcogrammoides chilensis and H. cunninghami based on museum specimens and fresh material. Allometric correction allows a better discrimination between both Helcogrammoides species. Our results suggest new measures both morphometric and meristic for the diagnosis of Helcogrammoides. © 2018, Universidad de Valparaiso. All rights reserved.https://revistas.uv.cl/index.php/rbmo/article/view/130

Supersymmetric Intersecting Branes on the Type IIA T^6/Z_4 orientifold

We study supersymmetric intersecting D6-branes wrapping 3-cycles in the Type IIA T^6/Z_4 orientifold background. As a new feature, the 3-cycles in this orbifold space arise both from the untwisted and the Z_2 twisted sectors. We present an integral basis for the homology lattice, H_3(M,Z), in terms of fractional 3-cycles, for which the intersection form involves the Cartan matrix of E8. We show that these fractional D6-branes can be used to construct supersymmetric brane configurations realizing a three generation Pati-Salam model. Via brane recombination processes preserving supersymmetry, this GUT model can be broken down to a standard-like model.Comment: 48 pages, TeX, harvmac, 8 figures, v4: some signs correcte

Orientifolds of K3 and Calabi-Yau Manifolds with Intersecting D-branes

We investigate orientifolds of type II string theory on K3 and Calabi-Yau 3-folds with intersecting D-branes wrapping special Lagrangian cycles. We determine quite generically the chiral massless spectrum in terms of topological invariants and discuss both orbifold examples and algebraic realizations in detail. Intriguingly, the developed techniques provide an elegant way to figure out the chiral sector of orientifold models without computing any explicit string partition function. As a new example we derive a non-supersymmetric Standard-like Model from an orientifold of type IIA on the quintic Calabi-Yau 3-fold with wrapped D6-branes. In the case of supersymmetric intersecting brane models on Calabi-Yau manifolds we discuss the D-term and F-term potentials, the effective gauge couplings and the Green-Schwarz mechanism. The mirror symmetric formulation of this construction is provided within type IIB theory. We finally include a short discussion about the lift of these models from type IIB on K3 to F-theory and from type IIA on Calabi-Yau 3-folds to M-theory on G_2 manifolds.Comment: 82 pages, harvmac, 5 figures. v2: references added. v3: T^6 orientifold corrected, JHEP versio

Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%

Structure and physiology of the RET receptor tyrosine kinase

10.1101/cshperspect.a009134Cold Spring Harbor Perspectives in Biology52

Cell-autonomous role of GFR?1 in the development of olfactory bulb GABAergic interneurons

10.1242/bio.033753Biology Open75bio033753

RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival

10.1016/j.celrep.2018.06.098Cell Reports2441013-102

MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating granule layer/white matter boundary

10.1038/s41419-019-1970-xCell Death and Disease101073

Correction: MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating granule layer/white matter boundary (Cell Death &amp; Disease, (2019), 10, 10, (732), 10.1038/s41419-019-1970-x)

10.1038/s41419-019-2058-3Cell Death and Disease101182