Additional file 1: of The impact of electronic records on patient safety: a qualitative study

Topic guide for interviews with NHS staff. Topic guide used for the qualitative interviews with study participants. Within the main text the topic guide is referenced as Additional file 1. (DOCX 18 kb

Electronic databases searched and number of results.

<p>Electronic databases searched and number of results.</p

Risk of bias graph displaying the overall study quality for all 46 studies.

<p>Risk of bias graph displaying the overall study quality for all 46 studies.</p

Flow chart documenting the screening process.

<p>Flow chart documenting the screening process.</p

Additional file 1: of Exploring the implementation of an electronic record into a maternity unit: a qualitative study using Normalisation Process Theory

Topic guide for interviews with NHS Staff: topic guide used for the qualitative interviews with study participants. (DOCX 18 kb

La Petite presse : journal quotidien... / [rédacteur en chef : Balathier Bragelonne]

01 novembre 18661866/11/01 (N196)

Potassium-Induced Release of an Endogenous Toxic Activity for Outer Hair Cells and Auditory Neurons in the Cochlea: A New Pathophysiological Mechanism in Meniere's Disease?

peer reviewedaudience: researcher, professional, studentIn Meniere's disease, the increase of extracellular potassium concentration in the perilymph is thought to play a key role in determining the progressive loss of cochlear hair cells. In this paper, we describe a serum-free culture preparation of hair cells from 5 day-old rat and report the release by the cochlea, in response to an increase of extracellular potassium concentration, of a cytotoxic activity active on hair cells and auditory neurons. The toxic activity is associated with low molecular weight (less than 10,000 Dalton) molecule(s) as revealed by ultrafiltration. Morphological studies performed on the organ of Corti incubated during 24 h in the presence of the cochlea-derived toxic activity (CTA), show that this factor is toxic for hair cells and not for supporting or surrounding cells. The release of CTA occurs both in the spiral ganglion and in the organ of Corti. We suggest that this cochlea-derived toxic activity may play an important role in the pathophysiology of the hearing loss that occurs during the progression of Meniere's disease

Additional file 1: of The patient reporting and action for a safe environment (PRASE) intervention: a feasibility study

Outline study design. Diagram of study design. (PDF 174 kb

Cost-Effectiveness Analysis of Acupuncture, Counselling and Usual Care in Treating Patients with Depression: The Results of the ACUDep Trial

<div><p>Background</p><p>New evidence on the clinical effectiveness of acupuncture plus usual care (acupuncture) and counselling plus usual care (counselling) for patients with depression suggests the need to investigate the health-related quality of life and costs of these treatments to understand whether they should be considered a good use of limited health resources.</p><p>Methods and Findings</p><p>The cost-effectiveness analyses are based on the Acupuncture, Counselling or Usual care for Depression (ACUDep) trial results. Statistical analyses demonstrate a difference in mean quality adjusted life years (QALYs) and suggest differences in mean costs which are mainly due to the price of the interventions. Probabilistic sensitivity analysis is used to express decision uncertainty. Acupuncture and counselling are found to have higher mean QALYs and costs than usual care. In the base case analysis acupuncture has an incremental cost-effectiveness ratio (ICER) of £4,560 per additional QALY and is cost-effective with a probability of 0.62 at a cost-effectiveness threshold of £20,000 per QALY. Counselling compared with acupuncture is more effective and more costly with an ICER of £71,757 and a probability of being cost-effective of 0.36. A scenario analysis of counselling versus usual care, excluding acupuncture as a comparator, results in an ICER of £7,935 and a probability of 0.91.</p><p>Conclusions</p><p>Acupuncture is cost-effective compared with counselling or usual care alone, although the ranking of counselling and acupuncture depends on the relative cost of delivering these interventions. For patients in whom acupuncture is unavailable or perhaps inappropriate, counselling has an ICER less than most cost-effectiveness thresholds. However, further research is needed to determine the most cost-effective treatment pathways for depressed patients when the full range of available interventions is considered.</p></div

CONSORT flow diagram.

<p>CONSORT flow diagram.</p