Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice

Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as “erva-cidreira” or “melissa”, it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigate in vivo its antigenotoxicity and antimutagenicity, as well as its genotoxic/mutagenic potential through comet and micronucleus assaying. CF-1 male mice were treated with ethanolic (Mo-EE) (250 or 500 mg/kg) or aqueous (Mo-AE) (100 mg/kg) solutions of an M. officinalis extract for 2 weeks, prior to treatment with saline or Methyl methanesulfonate (MMS) doses by intraperitoneal injection. Irrespective of the doses, no genotoxic or mutagenic effects were observed in blood and bone-marrow samples. Although Mo-EE exerted an antigenotoxic effect on the blood cells of mice treated with the alkylating agent (MMS) in all the doses, this was not so with Mo-AE. Micronucleus testing revealed the protector effect of Mo-EE, but only when administered at the highest dose. The implication that an ethanolic extract of M. officinalis has antigenotoxic/antimutagenic properties is an indication of its medicinal relevance

2 nd Brazilian Consensus on Chagas Disease, 2015

Abstract Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research

Declaracion, y limitacion de la Prematica publicada en esta Corte en catorze deste preferente mes y año. El Rey. Por quanto auiendolse publicado en esta Corte en catorze deste mes y año la Prematica. sobre la igualdad de las monedas, con presupuesto

Escut reial xil. a la capçalera del textLloc i data del text:"Dada en Madrid a diez de nouiembre de mil y seiscientos y cincuenta y dos años"ReclamsText signat per: "Martin de Villela"Declaració, i limitació de la Pragmàtica en aquesta Cort el catorze d'aquest preferent mes i any.

Instruccion que su Magestad manda guardar para la execucion de la prematica que en veynte y cinco de iunio deste año se ha promulgado, en razon de la reducion de la moneda gruessa de vellon, y satisfacion que se ha de dar de la Real Hazienda, a los parti

A 111/102(29

[Papeles de José Temprano] [Manuscrito]

Contiene: Documentos, prácticamente todos originales, relativos a José Temprano, en su mayoría de caracter real, en los cuales consta la firma autógrafa del rey Felipe IV y de los refrendos: Fernando Ruiz de Contreras, Martín de Villela, Alonso Pérez Cantarero, Antonio Carnero, Francisco de Galarreta, Luis de Oyaguren y Francisco de Noriega.Contiene además: Una carta en una h. suelta, al final de los documentos, de 1788, de Antonio Marco dirigida a José Judas RodrigoEn la h. 1 se ha escrito un tít.: "Condiçiones de Çamora para la Cavallería de Ordenança" pero falta el textoFoliación moderna, en la que no está numeradas todas las páginas; la h. [1] inicial en bl

Water quality assessment of the Sinos River, Southern Brazil

The Sinos River basin is located Northeast of the state of Rio Grande do Sul (29º 20' to 30º 10' S and 50º 15' to 51º20'W), Southern Brazil, covering two geomorphologic provinces: the Southern plateau and central depression. It is part of the Guaíba basin and has an area of approximately 800 km², encompassing 32 municipalities. The objective of this study was to monitor water quality in the Sinos River, the largest river in this basin. Water samples were collected at four selected sites in the Sinos River, and the following parameters were analysed: pH, dissolved oxygen, biochemical oxygen demand (BOD5), turbidity, fecal coliforms, total dissolved solids, temperature, nitrate, nitrite, phosphorous, chromium, lead, aluminum, zinc, iron, and copper. The results were analysed based on Resolution No. 357/2005 of the Brazilian National Environmental Council (CONAMA) regarding regulatory limits for residues in water. A second analysis was performed based on a water quality index (WQI) used by the Sinos River Basin Management Committee (COMITESINOS). Poor water quality in the Sinos River presents a worrying scenario for the region, since this river is the main source of water supply for the urban core. Health conditions found in the Sinos River, mainly in its lower reaches, are worrying and a strong indicator of human activities on the basin