DNA Repair Based Therapy in Oncology and Neurodegeneration

WOS: 000378333000015

POTENTIAL PROTECTIVE ROLE OF SDF-1 AND CXCR4 GENE VARIANTS IN THE DEVELOPMENT OF DEMENTIA

Background: The aim of this study was to evaluate the role of polymorphisms of stromal cell-derived factor-1 (SDF-1) and chemokine receptor-4 (CXCR4) genes in dementia susceptibility in a Turkish population. Subjects and methods: The study group included 61 dementia patients, while the control group comprised 82 healthy individuals. Gene polymorphisms of SDF-1 3’A G801A (rs1801157) and CXCR4 C138T (rs2228014) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: A significantly reduced risk for developing dementia was found for the group bearing an A allele for SDF-1 3’A polymorphism (p=0.009; x2=6.812; OR=0.626; 95%CI= 0.429-0.913). The frequency of the CXCR4 TT and TC genotype was significantly lower in patients with dementia compared to controls (p=0.028; x2=5.583; OR=0.215; 95%CI=0.05-0.914); (p=0.027; x2=4.919; OR=0.484; 95% CI= 0.246-0.955). Additionally, combined genotype analysis showed that the frequency of SDF1 GACXCR4 CC was significantly lower in patients with dementia in comparison with those of controls (p=0.049; OR=0.560; 95% CI= 0.307±1.020). Conclusions: Our study provides new evidence that SDF1 A and CXCR4 T alleles may be associated with a decreased dementia risk. The present study is important because to our knowledge, it is the first one to be conducted in a Turkish population to date, but we believe that more patients and controls are needed to obtain statistically significant results

The Distribution of Exon 3-Deleted/Full-Length Growth Hormone Receptor Polymorphism in the Turkish Population

Objective: The exon 3-deleted/full-length (d3/fl) growth hormone receptor (d3/fl-GHR) polymorphism has been associated with responsiveness to GH therapy in some children and also with adult height variation in the general population. We aimed to evaluate the distribution of d3/fl-GHR polymorphism in a Turkish population

Advances in Lipoprotein Research

Lipoproteins have key roles in human growth and development, along with promoting, preventing, and/or participating in the pathogenesis or in the treatment of various diseases. This book presents a systematic and comprehensive review about the structure and metabolism of lipoproteins, particularly highlighting the crucial role of those molecules in the body and considering the interest of some lipids in healthy and diseased conditions. This book aims to provide integrative approach to understand the lipoprotein metabolism. Distinguished international experts contributed six chapters about the genetic variations, plasma lipoprotein components, and molecular relationship of lipoproteins with cognition and obesity

Enhanced casein kinase II (CK II) activity in human lung tumours

Background: Casein kinase 11 (CK II) is expressed at a higher level in lung tumours when compared to the corresponding non-neoplastic lung tissue. Materials and Methods: The aim of the present study was to evaluate the activity of CK II both in neoplastic and non-neoplastic human lung tissue by using a synthetic peptide with Arg-Arg-Arg-Asp-Asp-Asp-Ser-Asp-Asp-Asp (RRRDDDSDDD) sequence. One unit of CK If activity is defined as the amount catalysing the transfer of I pmol P-32 into the substrate within I minute at 37degreesC. Results: The activities measured for the neoplastic and non-neoplastic tissues were 1250-1500 U/mg protein and 100-500 U/mg protein, respectively. According to these results, the maximum activity observed in the lung carcinomas was 2 to 3-fold higher than the lung tumour specimens when compared to the non-neoplastic lung tissue. The activity range of CK II was between 500-1500 U mg protein. Conclusion: Our results suggest that CK 11 plays an important role in cellular proliferation and the mechanism of its activation