3,339 research outputs found
EXPLOITING TIME DIVERSITY TO IMPROVE BLOCK SPREAD OFDM
This paper presents a new method to improve on block spread OFDM by exploiting time diversity to ensure that the blocks are independent and uncorrelated. Simulation results have shown significant improvement over conventional OFDM and Block Spread OFDM
STUDY OF SPREAD CODES WITH BLOCK SPREAD OFDM
This paper presents the study undertaken with block spread OFDM and compares three spreading matrices. The matrices include the Hadamard, Rotated Hadamard and Mutually Orthogonal Complementary Sets of Sequences (MOCSS). The study is carried out for block lengths of M = 2, M = 4 and M = 8 and it shows that all the spreading matrices show improvement and a better performance over the conventional OFDM over frequency selective channel as expected. As the size ofM increased the spreading matrices which have better orthogonal qualities show greater improvemen
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Human preferences for sexually dimorphic faces may be evolutionarily novel
This article has been made available through the Brunel Open Access Publishing Fund.A large literature proposes that preferences for exaggerated sex typicality in human faces (masculinity/femininity) reflect a long evolutionary history of sexual and social selection. This proposal implies that dimorphism was important to judgments of attractiveness and personality in ancestral environments. It is difficult to evaluate, however, because most available data come from largescale, industrialized, urban populations. Here, we report the results for 12 populations with very diverse levels of economic development. Surprisingly, preferences for exaggerated sex-specific traits are only found in the novel, highly developed environments. Similarly, perceptions that masculine males look aggressive increase strongly with development, specifically, urbanization. These data challenge the hypothesis that facial dimorphism was an important ancestral signal of heritable mate value. One possibility is that highly developed environments provide novel opportunities to discern relationships between facial traits and behavior by exposing individuals to large numbers of unfamiliar faces, revealing patterns too subtle to detect with smaller samples
Noncommutative Dipole Field Theories And Unitarity
We extend the argument of Gomis and Mehen for violation of unitarity in field
theories with space-time noncommutativity to dipole field theories. In dipole
field theories with a timelike dipole vector, we present 1-loop amplitudes that
violate the optical theorem. A quantum mechanical system with nonlocal
potential of finite extent in time also shows violation of unitarity.Comment: typos corrected, more details added in Sec 5, version to appear in
JHE
Searching for Exoplanets Using a Microresonator Astrocomb
Detection of weak radial velocity shifts of host stars induced by orbiting
planets is an important technique for discovering and characterizing planets
beyond our solar system. Optical frequency combs enable calibration of stellar
radial velocity shifts at levels required for detection of Earth analogs. A new
chip-based device, the Kerr soliton microcomb, has properties ideal for
ubiquitous application outside the lab and even in future space-borne
instruments. Moreover, microcomb spectra are ideally suited for astronomical
spectrograph calibration and eliminate filtering steps required by conventional
mode-locked-laser frequency combs. Here, for the calibration of astronomical
spectrographs, we demonstrate an atomic/molecular line-referenced,
near-infrared soliton microcomb. Efforts to search for the known exoplanet HD
187123b were conducted at the Keck-II telescope as a first in-the-field
demonstration of microcombs
Spectral Line-by-Line Pulse Shaping of an On-Chip Microresonator Frequency Comb
We report, for the first time to the best of our knowledge, spectral phase
characterization and line-by-line pulse shaping of an optical frequency comb
generated by nonlinear wave mixing in a microring resonator. Through
programmable pulse shaping the comb is compressed into a train of
near-transform-limited pulses of \approx 300 fs duration (intensity full width
half maximum) at 595 GHz repetition rate. An additional, simple example of
optical arbitrary waveform generation is presented. The ability to characterize
and then stably compress the frequency comb provides new data on the stability
of the spectral phase and suggests that random relative frequency shifts due to
uncorrelated variations of frequency dependent phase are at or below the 100
microHertz level.Comment: 18 pages, 4 figure
Histopathological analysis of the non - tumour parenchyma following radical nephrectomy: can it predict renal functional outcome?
Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk
Breast cancer is a major cause of cancer-related deaths in women. It is known that obesity is one of the risk factors of breast cancer. The subject of our interest was genes: FTO, MC4R and NRXN3–associated with obesity. In this study we have analyzed frequencies of genomic variants in FTO, MC4R and NRXN3 in the group of 134 breast cancer patients. We genotyped two polymorphic sites located in FTO gene (rs993909 and rs9930506), one polymorphic site of MC4R gene (rs17782313) and one polymorphic site of NRXN3 gene (rs10146997). Our hypothesis was that above mentioned SNPs could participate in carcinogenesis. Our research has showed that only rs10146997 was significantly (P = 0.0445) associated with higher risk of breast cancer development (OR = 0.66 (95% CI 0.44–0.99)). Moreover, G allele carriers in rs10146997 of the NRXN3 gene were the youngest patients at onset of breast cancer. On the basis of our research we suggest that further functional may elucidate the role of genomic variation in breast cancer development
Numerical studies of the ABJM theory for arbitrary N at arbitrary coupling constant
We show that the ABJM theory, which is an N=6 superconformal U(N)*U(N)
Chern-Simons gauge theory, can be studied for arbitrary N at arbitrary coupling
constant by applying a simple Monte Carlo method to the matrix model that can
be derived from the theory by using the localization technique. This opens up
the possibility of probing the quantum aspects of M-theory and testing the
AdS_4/CFT_3 duality at the quantum level. Here we calculate the free energy,
and confirm the N^{3/2} scaling in the M-theory limit predicted from the
gravity side. We also find that our results nicely interpolate the analytical
formulae proposed previously in the M-theory and type IIA regimes. Furthermore,
we show that some results obtained by the Fermi gas approach can be clearly
understood from the constant map contribution obtained by the genus expansion.
The method can be easily generalized to the calculations of BPS operators and
to other theories that reduce to matrix models.Comment: 35 pages, 20 figures; reference added. The simulation code is
available upon request to [email protected]
Deriving a mutation index of carcinogenicity using protein structure and protein interfaces
With the advent of Next Generation Sequencing the identification of mutations in the genomes of healthy and diseased tissues has become commonplace. While much progress has been made to elucidate the aetiology of disease processes in cancer, the contributions to disease that many individual mutations make remain to be characterised and their downstream consequences on cancer phenotypes remain to be understood. Missense mutations commonly occur in cancers and their consequences remain challenging to predict. However, this knowledge is becoming more vital, for both assessing disease progression and for stratifying drug treatment regimes. Coupled with structural data, comprehensive genomic databases of mutations such as the 1000 Genomes project and COSMIC give an opportunity to investigate general principles of how cancer mutations disrupt proteins and their interactions at the molecular and network level. We describe a comprehensive comparison of cancer and neutral missense mutations; by combining features derived from structural and interface properties we have developed a carcinogenicity predictor, InCa (Index of Carcinogenicity). Upon comparison with other methods, we observe that InCa can predict mutations that might not be detected by other methods. We also discuss general limitations shared by all predictors that attempt to predict driver mutations and discuss how this could impact high-throughput predictions. A web interface to a server implementation is publicly available at http://inca.icr.ac.uk/
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