Improving antibiotic prescribing for children in the resource-poor setting.

Antibiotics are a critically important part of paediatric medical care in low- and middle-income countries (LMICs), where infectious diseases are the leading cause of child mortality. The World Health Organization estimates that >50% of all medicines are prescribed, dispensed or sold inappropriately and that half of all patients do not take their medicines correctly. Given the rising prevalence of antimicrobial resistance globally, inappropriate antibiotic use is of international concern, and countries struggle to implement basic policies promoting rational antibiotic use. Many barriers to rational paediatric prescribing in LMICs persist. The World Health Organization initiatives, such as 'Make medicines child size', the Model List of Essential Medicines for Children and the Model Formulary for Children, have been significant steps forward. Continued strategies to improve access to appropriate drugs and formulations, in conjunction with improved evidence-based clinical guidelines and dosing recommendations, are essential to the success of such initiatives on both a national and an international level. This paper provides an overview of these issues and considers future developments that may improve LMIC antibiotic prescribing

Trigonometric Parallaxes for 1,507 Nearby Mid-to-Late M-dwarfs

The MEarth survey is a search for small rocky planets around the smallest, nearest stars to the Sun as identified by high proper motion with red colors. We augmented our planetary search time series with lower cadence astrometric imaging and obtained two million images of approximately 1800 stars suspected to be mid-to-late M dwarfs. We fit an astrometric model to MEarth's images for 1507 stars and obtained trigonometric distance measurements to each star with an average precision of 5 milliarcseconds. Our measurements, combined with the 2MASS photometry, allowed us to obtain an absolute K_s magnitude for each star. In turn, this allows us to better estimate the stellar parameters than those obtained with photometric estimates alone and to better prioritize the targets chosen to monitor at high cadence for planetary transits. The MEarth sample is mostly complete out to a distance of 25 parsecs for stars of type M5.5V and earlier, and mostly complete for later type stars out to 20 parsecs. We find eight stars that are within ten parsecs of the Sun for which there did not exist a published trigonometric parallax distance estimate. We release with this work a catalog of the trigonometric parallax measurements for 1,507 mid-to-late M-dwarfs, as well as new estimates of their masses and radii.Comment: ApJ, accepted. 36 pages, 8 figures, 2 tables. Please find our data table here: http://www.cfa.harvard.edu/MEarth/DataDR2.htm

The rotation and Galactic kinematics of mid M dwarfs in the Solar Neighborhood

Rotation is a directly-observable stellar property, and drives magnetic field generation and activity through a magnetic dynamo. Main sequence stars with masses below approximately 0.35Msun (mid-to-late M dwarfs) are fully-convective, and are expected to have a different type of dynamo mechanism than solar-type stars. Measurements of their rotation rates provide insights into these mechanisms, but few rotation periods are available for these stars at field ages. Using photometry from the MEarth transit survey, we measure rotation periods for 387 nearby, mid-to-late M dwarfs in the Northern hemisphere, finding periods from 0.1 to 140 days. The typical detected rotator has stable, sinusoidal photometric modulations at a semi-amplitude of 0.5 to 1%. We find no period-amplitude relation for stars below 0.25Msun and an anti-correlation between period and amplitude for higher-mass M dwarfs. We highlight the existence of older, slowly-rotating stars without H{\alpha} emission that nevertheless have strong photometric variability. The Galactic kinematics of our sample is consistent with the local population of G and K dwarfs, and rotators have metallicities characteristic of the Solar Neighborhood. We use the W space velocities and established age-velocity relations to estimate that stars with P<10 days are on average <2 Gyrs, and that those with P>70 days are about 5 Gyrs. The period distribution is mass dependent: as the mass decreases, the slowest rotators at a given mass have longer periods, and the fastest rotators have shorter periods. We find a lack of stars with intermediate rotation periods. [Abridged]Comment: Accepted to ApJ. Machine readable tables and additional figures are available in the published article or on reques

AAT/WFI observations of the Extragalactic H I Cloud HIPASS J1712-64

AAT/WFI optical images of a candidate extragalactic HI cloud, HIPASS J1712-64, are presented. The g and r-band CCD mosaic camera frames were processed using a new data pipeline recently installed at the AAO. The resultant stacked images reach significantly deeper levels than those of previous published optical imaging of this candidate, providing a detection limit M_g -7 at a distance of 3Mpc, the inferred distance to HIPASS J1712-64. However, detailed analysis of the images fails to uncover any stellar population associated with the HI emission. If this system is a member of the Local Group then it is pathologically different to other members. Hence, our observations reinforce earlier suggestions that this HI cloud is most likely Galactic in origin and not a Local Volume dwarf galaxy.Comment: 8 pages, accepted for publication in PASA (Figures reduced in resolution, please contact gfl if you wish the higher resolution versions

A Search for Additional Bodies in the GJ 1132 Planetary System from 21 Ground-based Transits and a 100 Hour Spitzer Campaign

We present the results of a search for additional bodies in the GJ 1132 system through two methods: photometric transits and transit timing variations of the known planet. We collected 21 transit observations of GJ 1132b with the MEarth-South array since 2015. We obtained 100 near-continuous hours of observations with the $Spitzer$ Space Telescope, including two transits of GJ 1132b and spanning 60\% of the orbital phase of the maximum period at which bodies coplanar with GJ 1132b would pass in front of the star. We exclude transits of additional Mars-sized bodies, such as a second planet or a moon, with a confidence of 99.7\%. When we combine the mass estimate of the star (obtained from its parallax and apparent $K_s$ band magnitude) with the stellar density inferred from our high-cadence $Spitzer$ light curve (assuming zero eccentricity), we measure the stellar radius of GJ 1132 to be $0.2105^{+0.0102}_{-0.0085} R_\odot$, and we refine the radius measurement of GJ 1132b to $1.130 \pm 0.056 R_\oplus$. Combined with HARPS RV measurements, we determine the density of GJ 1132b to be $6.2 \pm 2.0$\ g cm$^{-3}$, with the mass determination dominating this uncertainty. We refine the ephemeris of the system and find no evidence for transit timing variations, which would be expected if there was a second planet near an orbital resonance with GJ 1132b.Comment: 29 pages, 4 Tables, 8 Figures, Submitted to ApJ. Comments welcom

Mindfulness Meditation Activates Altruism.

Clinical evidence suggests that mindfulness meditation reduces anxiety, depression, and stress, and improves emotion regulation due to modulation of activity in neural substrates linked to the regulation of emotions and social preferences. However, less was known about whether mindfulness meditation might alter pro-social behavior. Here we examined whether mindfulness meditation activates human altruism, a component of social cooperation. Using a simple donation game, which is a real-world version of the Dictator's Game, we randomly assigned 326 subjects to a mindfulness meditation online session or control and measured their willingness to donate a portion of their payment for participation as a charitable donation. Subjects who underwent the meditation treatment donated at a 2.61 times higher rate than the control (p = 0.005), after controlling for socio-demographics. We also found a larger treatment effect of meditation among those who did not go to college (p &lt; 0.001) and those who were under 25 years of age (p &lt; 0.001), with both subject groups contributing virtually nothing in the control condition. Our results imply high context modularity of human altruism and the development of intervention approaches including mindfulness meditation to increase social cooperation, especially among subjects with low baseline willingness to contribute

Investigation of reactivity of launch vehicle materials with liquid oxygen Quarterly report, 23 Jul. - 22 Oct. 1968

Reactivity of launch vehicle organic materials with liquid oxyge