How has internet addiction research evolved since the advent of internet gaming disorder? An overview of cyberaddictions from a psychological perspective

During the past two decades, Internet addiction (IA) has been the most commonly used term in research into online activities and their influence on the development of behavioral addictions. The aim of this review is to assess the impact of the concept of Internet gaming disorder (IGD), proposed by the American Psychiatric Association, on the scientific literature regarding IA. It presents a bibliometric analysis of the IA literature starting from the time IGD was first proposed, with the objective of observing and comparing the topics that have arisen during this period among the different IA themes researched. The findings demonstrate a steady evolution, particularly regarding publications related to the general aspects of IA: its clinical component, its prevalence and psychometric measures, the growing interest in the contextual factors promoting this addictive behavior, scientific progress in its conceptualization based on existing theoretical models, and neuropsychological studies. Nevertheless, many of the studies (22 %) focus on specific IA behaviors and show heterogeneity among the cyberaddictions, with online gaming (related to IGD) most common, followed by cybersex and social networking. Although research on the general concept of IA continues, investigators have begun to pay attention to the diverse spectrum of specific cyberaddictions and their psychological components

Gambling behavior among underage adolescents in Hong Kong

2010-2011 > Academic research: refereed > Publication in refereed journal201902_a bcmaVersion of RecordPublishe

Internet gambling among high school students in Hong Kong

202012 bcrcVersion of RecordPublishe

Flavonoid dimers and their use

US8980848; US8980848 B2; US8980848B2; US8,980,848; US 8,980,848 B2; 8980848; Appl. No. 13/695,697US2014-2015 > Other Outputs > Patents grantedVersion of Recor

Rapid reduction of pentavalent antimony by trypanothione: Potential relevance to antimonial activation

The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.link_to_subscribed_fulltex

Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents

US10111854; US10111854 B2; US10111854B2; US10,111,854; US10,111,854 B2; 10111854; Appl. No. 15/425,481US202006 bcrcVersion of Recor

Complexation of antimony (SbV) with guanosine 5′-monophosphate and guanosine 5′-diphospho-D-mannose: Formation of both mono- and bis-adducts

In spite of the extensive use of pentavalent antimony chemotherapy, the mechanism of its anti-leishmania action is still not clear. Here, we report the interactions of SbV, including the clinically used drug stibogluconate, with guanosine 5′-monophosphate (5′-GMP) and guanosine 5′-diphospho-d-mannose (5′-GDP-mannose) in aqueous solution. The deprotonated hydroxyl groups (-OH) of the ribose ring are shown to be the binding site for SbV, probably via chelation. Both mono- and bis-adducts were formed as determined by NMR, high performance liquid chromatography (HPLC) and electrospray ionization mass spectrometry (ESI-MS), and both of them are stable in the pH range of 4 to around 9.5. The formation of the mono-adduct (k1 = 1.67 × 10-3 and 3.43 × 10-3 mM-1 min-1 for Sb(5′-GMP) and Sb(5′-GDP-mannose), respectively, at 298 K) was 10-fold faster than that of the bis-adduct (k2 = 0.16 × 10-3 and 0.21 × 10-3 mM-1 min-1, for Sb(5′-GMP) 2 and Sb(5′-GDP-mannose)2, respectively), and the mono-adduct was the major species in solution with the [bis-adduct]/[mono- adduct] < 0.5. The reactions of stibogluconate with 5′-GMP and 5′-GDP-mannose were slower than that of antimonate under similar conditions. © 2005 Elsevier Inc. All rights reserved.link_to_subscribed_fulltex