An optimization method for designing high rate and high performance SCTCM systems with in-line interleavers

We present a method for designing high-rate, high-performance SCTCM systems with in-line interleavers. Using in-line EXIT charts and ML performance analysis, we develop criteria for choosing constituent codes and optimization methods for selecting the best ones. To illustrate our methods, we show that an optimized SCTCM system with an in-line interleaver for rate r = 5/6 and 64QAM has better performance than other turbo-like TCMs with the same parameters

Annotating a Japanese text corpus with predicate-argument and coreference relations

In this paper, we discuss how to annotate coreference and predicate-argument relations in Japanese written text. There have been research activities for building Japanese text corpora annotated with coreference and predicate-argument relations as are done in the Kyoto Text Corpus version 4.0 (Kawahara et al., 2002) and the GDA-Tagged Corpus (Hasida, 2005). However, there is still much room for refining their specifications. For this reason, we discuss issues in annotating these two types of relations, and propose a new specification for each. In accordance with the specification, we built a large-scaled annotated corpus, and examined its reliability. As a result of our current work, we have released an annotated corpus named the NAIST Text Corpus1, which is used as the evaluation data set in the coreference and zero-anaphora resolution tasks in Iida et al. (2005) and Iida et al. (2006).

Influence of the step number of the approach run on the jumping kinematics in volleyball spike jumps

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 15, 2023. In volleyball, the approach run serves as a strategy to execute a spike from an elevated striking position. Nevertheless, the influence of the step number of the approach run on the jumping kinematics in spike jumps is unclear. Therefore, this investigation aims to clarify the impact of varying step numbers within the approach run on jumping kinematics. Seven female volleyball athletes were tasked with executing spike jumps, employing 2 and 3-step approach runs. These trials were recorded using high-speed cameras and digitized, and then the kinematics of the 2 and 3-step trials were compared. The findings of this study unveiled that, in the 3-step trial with higher horizontal velocity, the center of gravity was upheld at an elevated level, thereby curtailing the vertical displacement of the center of gravity from the last step before the takeoff to the takeoff. Within the 2-step trial, a notable deceleration of horizontal velocity in the first half of the takeoff was virtually absent. However, the 3-step trial with higher horizontal velocity entailed more flexion of the dominant knee joint to decelerate the horizontal velocity during the first half. Furthermore, the 3-step trial entails a swifter extension of the hip, knee, and ankle joints of the non-dominant leg. This accelerated extension likely contributes to an augmented vertical velocity at the foot release of the takeoff

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

神経幹細胞の運命を決める分子を発見 --脳形成機構の解明と脳腫瘍や精神疾患の治療法に期待--. 京都大学プレスリリース. 2020-09-28.During brain development, neural stem cells (NSCs) initially produce neurons and change their fate to generate glias. While the regulation of neurogenesis is well characterized, specific markers for glial precursor cells (GPCs) and the master regulators for gliogenesis remain unidentified. Accumulating evidence suggests that RNA-binding proteins (RBPs) have significant roles in neuronal development and function, as they comprehensively regulate the expression of target genes in a cell-type-specific manner. We systematically investigated the expression profiles of 1, 436 murine RBPs in the developing mouse brain and identified quaking (Qk) as a marker of the putative GPC population. Functional analysis of the NSC-specific Qk-null mutant mouse revealed the key role of Qk in astrocyte and oligodendrocyte generation and differentiation from NSCs. Mechanistically, Qk upregulates gliogenic genes via quaking response elements in their 3′ untranslated regions. These results provide crucial directions for identifying GPCs and deciphering the regulatory mechanisms of gliogenesis from NSCs

The Impact of Reduced Skeletal Muscle Mass on Patients with Knee Osteoarthritis

Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy

Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which induces genetic/epigenetic alterations in the chromosomes of melanocytes. In human melanomas, the RAS/RAF/MEK/ERK (MAPK) and the PI3K/PTEN/AKT (AKT) signaling pathways are two major signaling pathways and are constitutively activated through genetic alterations. Mutations of RAF, RAS, and PTEN contribute to antiapoptosis, abnormal proliferation, angiogenesis, and invasion for melanoma development and progression. To find better approaches to therapies for patients, understanding these MAPK and AKT signaling mechanisms of melanoma development and progression is important. Here, we review MAPK and AKT signaling networks associated with melanoma development and progression

Molecular Network Associated with MITF in Skin Melanoma Development and Progression

Various environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epigenetic alterations occur in skin melanocytes. These first triggers alter the conditions of numerous genes and proteins, and they induce and/or reduce gene expression and activate and/or repress protein stability and activity, resulting in melanoma progression. Microphthalmia-associated transcription factor (MITF) is a master regulator gene of melanocyte development and differentiation and is also associated with melanoma development and progression. To find better approaches to molecular-based therapies for patients, understanding MITF function in skin melanoma development and progression is important. Here, we review the molecular networks associated with MITF in skin melanoma development and progression