1 research outputs found
A Collaborative Filtering Approach for Protein-Protein Docking Scoring Functions
A protein-protein docking procedure traditionally consists in two successive
tasks: a search algorithm generates a large number of candidate conformations
mimicking the complex existing in vivo between two proteins,
and a scoring function is used to rank them in order to extract a native-like
one. We have already shown that using Voronoi constructions and a well chosen
set of parameters, an accurate scoring function could be designed and optimized.
However to be able to perform large-scale in silico exploration
of the interactome, a near-native solution has to be found in the ten
best-ranked solutions. This cannot yet be guaranteed by any of the existing
scoring functions