POD-mode-augmented wall model and its applications to flows at non-equilibrium conditions

Insights gained from modal analysis are invoked for predictive large-eddy simulation (LES) wall modeling. Specifically, we augment the law of the wall (LoW) by an additional mode based on a one-dimensional proper orthogonal decomposition (POD) applied to a 2D turbulent channel. The constructed wall model contains two modes, i.e., the LoW mode and the POD-based mode, and the model matches with the LES at two, instead of one, off-wall locations. To show that the proposed model captures non-equilibrium effects, we perform a-priori and a-posteriori tests in the context of both equilibrium and non-equilibrium flows. The a-priori tests show that the proposed wall model captures extreme wall-shear stress events better than the equilibrium wall model. The model also captures non-equilibrium effects due to adverse pressure gradients. The a-posteriori tests show that the wall model captures the rapid decrease and the initial decrease of the streamwise wall-shear stress in channels subjected to suddenly imposed adverse and transverse pressure gradients, respectively, both of which are missed by currently available wall models. These results show promise in applying modal analysis for turbulence wall modeling. In particular, the results show that employing multiple modes helps in the modeling of non-equilibrium flows

Navigating a Social Justice Motivation and Praxis as Student Affairs Professionals

While diversity and social justice are espoused values of the field of student affairs, student affairs professionals are socialized to varying degrees in regard to the awareness, knowledge, and skills necessary to be social justice advocates. Through qualitative interviews with nine entry- and mid-level student affairs professionals, we explored the motivations and experiences of student affairs professionals who enact values of social justice in their praxis. Participants shared strategies to navigating the field and their advocacy, the influence of theirs and others’ identities on their work, techniques for implementing intentional social justice praxis, challenges faced in their advocacy, and how they practice self-care

Tumour burden score for hepatocellular carcinoma: Is it an authentic prognostic marker?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163375/2/bjs11927.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163375/1/bjs11927_am.pd

Ultrafine particle transport and deposition in a large scale 17-generation lung model

© 2017 Elsevier Ltd To understand how to assess optimally the risks of inhaled particles on respiratory health, it is necessary to comprehend the uptake of ultrafine particulate matter by inhalation during the complex transport process through a non-dichotomously bifurcating network of conduit airways. It is evident that the highly toxic ultrafine particles damage the respiratory epithelium in the terminal bronchioles. The wide range of in silico available and the limited realistic model for the extrathoracic region of the lung have improved understanding of the ultrafine particle transport and deposition (TD) in the upper airways. However, comprehensive ultrafine particle TD data for the real and entire lung model are still unavailable in the literature. Therefore, this study is aimed to provide an understanding of the ultrafine particle TD in the terminal bronchioles for the development of future therapeutics. The Euler-Lagrange (E-L) approach and ANSYS fluent (17.2) solver were used to investigate ultrafine particle TD. The physical conditions of sleeping, resting, and light activity were considered in this modelling study. A comprehensive pressure-drop along five selected path lines in different lobes was calculated. The non-linear behaviour of pressure-drops is observed, which could aid the health risk assessment system for patients with respiratory diseases. Numerical results also showed that ultrafine particle-deposition efficiency (DE) in different lobes is different for various physical activities. Moreover, the numerical results showed hot spots in various locations among the different lobes for different flow rates, which could be helpful for targeted therapeutical aerosol transport to terminal bronchioles and the alveolar region

Polydisperse Microparticle Transport and Deposition to the Terminal Bronchioles in a Heterogeneous Vasculature Tree

© 2018, The Author(s). The atmospheric particles from different sources, and the therapeutic particles from various drug delivery devices, exhibit a complex size distribution, and the particles are mostly polydisperse. The limited available in vitro, and the wide range of in silico models have improved understanding of the relationship between monodisperse particle deposition and therapeutic aerosol transport. However, comprehensive polydisperse transport and deposition (TD) data for the terminal airways is still unavailable. Therefore, to benefit future drug therapeutics, the present numerical model illustrates detailed polydisperse particle TD in the terminal bronchioles for the first time. Euler-Lagrange approach and Rosin-Rammler diameter distribution is used for polydisperse particles. The numerical results show higher deposition efficiency (DE) in the right lung. Specifically, the larger the particle diameter (dp > 5 μm), the higher the DE at the bifurcation area of the upper airways is, whereas for the smaller particle (dp < 5 μm), the DE is higher at the bifurcation wall. The overall deposition pattern shows a different deposition hot spot for different diameter particle. These comprehensive lobe-specific polydisperse particle deposition studies will increase understanding of actual inhalation for particle TD, which could potentially increase the efficiency of pharmaceutical aerosol delivery at the targeted position of the terminal airways

HetFS: A heterogeneous file system for everyone

Storage devices have been getting more and more diverse during the last decade. The advent of SSDs made it painfully clear that rotating devices, such as HDDs or magnetic tapes, were lacking in regards to response time. However, SSDs currently have a limited number of write cycles and a significantly larger price per capacity, which has prevented rotational technologies from begin abandoned. Additionally, Non-Volatile Memories (NVMs) have been lately gaining traction, offering devices that typically outperform NAND-based SSDs but exhibit a full new set of idiosyncrasies. Therefore, in order to appropriately support this diversity, intelligent mechanisms will be needed in the near-future to balance the benefits and drawbacks of each storage technology available to a system. In this paper, we present a first step towards such a mechanism called HetFS, an extension to the ZFS file system that is capable of choosing the storage device a file should be kept in according to preprogrammed filters. We introduce the prototype and show some preliminary results of the effects obtained when placing specific files into different devices.The research leading to these results has received funding from the European Community under the BIGStorage ETN (Project 642963 of the H2020-MSCA-ITN-2014), by the Spanish Ministry of Economy and Competitiveness under the TIN2015-65316 grant and by the Catalan Government under the 2014-SGR- 1051 grant. To learn more about the BigStorage project, please visit http: //bigstorage-project.eu/.Peer ReviewedPostprint (author's final draft

Inhaled corticosteroids for chronic obstructive pulmonary disease-the shifting treatment paradigm

Chronic obstructive pulmonary disease (COPD) guidelines suggest using inhaled corticosteroids (ICS) in patients with severe airflow limitation or those at high risk of exacerbations. This recommendation is based on evidence demonstrating that ICS, especially when prescribed in fixed-dose combinations (FDC) with long-acting β2 agonists (LABA), improve quality of life (QoL), decrease exacerbations and hospitalisations, and have been associated with a trend towards a reduction in all-cause mortality. Audit shows that routine prescribing practice frequently uses inhaler therapies outside current guidelines recommendations; severe to very severe disease constitutes about 20% of all COPD patients, but up to 75% of COPD patients are prescribed an ICS, with significant numbers given ICS/LABA as first-line maintenance therapy. The role of ICS in the treatment paradigm for COPD is changing, driven by the growing evidence of increased risk of pneumonia, and the introduction of a new class of FDC; LABA and long-acting muscarinic antagonists (LAMA), which simplify dual bronchodilation and present a plausible alternative therapy. As the evidence base for dual therapy bronchodilation expands, it is likely that maximal bronchodilation will move up the treatment algorithm and ICS reserved for those with more severe disease who are not controlled on dual therapy. This change has already manifested in local COPD algorithms, such as those at Tayside, and represents a significant change in recommended prescribing practice. This review reassesses the role of ICS in the shifting treatment paradigm, in the context of alternative treatment options that provide maximal bronchodilation

Kinks in the dispersion of strongly correlated electrons

The properties of condensed matter are determined by single-particle and collective excitations and their interactions. These quantum-mechanical excitations are characterized by an energy E and a momentum \hbar k which are related through their dispersion E_k. The coupling of two excitations may lead to abrupt changes (kinks) in the slope of the dispersion. Such kinks thus carry important information about interactions in a many-body system. For example, kinks detected at 40-70 meV below the Fermi level in the electronic dispersion of high-temperature superconductors are taken as evidence for phonon or spin-fluctuation based pairing mechanisms. Kinks in the electronic dispersion at binding energies ranging from 30 to 800 meV are also found in various other metals posing questions about their origins. Here we report a novel, purely electronic mechanism yielding kinks in the electron dispersions. It applies to strongly correlated metals whose spectral function shows well separated Hubbard subbands and central peak as, for example, in transition metal-oxides. The position of the kinks and the energy range of validity of Fermi-liquid (FL) theory is determined solely by the FL renormalization factor and the bare, uncorrelated band structure. Angle-resolved photoemission spectroscopy (ARPES) experiments at binding energies outside the FL regime can thus provide new, previously unexpected information about strongly correlated electronic systems.Comment: 8 pages, 5 figure

Land-Use Experiments in the Loch Laidon Catchment

This report presents the results from the Stream Water Quality component of the Loch Laidon catchment land-use experiment which commenced in 1992. The experiment was established with the aim of examining the effects of cattle grazing on the aquatic and terrestrial habitats and biota of a moorland area of upland Scotland

Ultracold Gases of Ytterbium: Ferromagnetism and Mott States in an SU(6) Fermi System

It is argued that ultracold quantum degenerate gas of ytterbium $^{173}$Yb atoms having nuclear spin $I = 5/2$ exhibits an enlarged SU$(6)$ symmetry. Within the Landau Fermi liquid theory, stability criteria against Fermi liquid (Pomeranchuk) instabilities in the spin channel are considered. Focusing on the SU$(n > 2)$ generalizations of ferromagnetism, it is shown within mean-field theory that the transition from the paramagnet to the itinerant ferromagnet is generically first order. On symmetry grounds, general SU$(n)$ itinerant ferromagnetic ground states and their topological excitations are also discussed. These SU$(n > 2)$ ferromagnets can become stable by increasing the scattering length using optical methods or in an optical lattice. However, in an optical lattice at current experimental temperatures, Mott states with different filling are expected to coexist in the same trap, as obtained from a calculation based on the SU$(6)$ Hubbard model.Comment: 4+ pages, 1 figure; v2: Improved discussion of the SU(6) symmetry-breaking patterns; v3: added further discussion on the order of the transition. Added Reference