9 research outputs found
Human leukocyte antigens as genetic markers in Greek patients with sporadic pancreatic cancer
Purpose: In this study we investigated the relationship between specific
HLA antigens and sporadic pancreatic cancer in Greek population.
Methods: The allele frequencies of serologically and molecular defined
class I and II HLA antigens were studied in 60 unrelated patients with
pancreatic cancer histologically confirmed. The results obtained for HLA
frequencies were compared with those of 105 healthy control subjects
(control group).
Results: Increased frequencies of HLA-A30 (16.7 vs. 3.8%; P < 0.01; OR
= 5.05), A31 (9.5 vs. 1.9%; P < 0.05; OR = 5.72), B18 (31.7 vs.
14.3%,- P < 0.05; OR = 2.78) and Cw7 (53.3 vs. 21.9%; P < 0.01; OR =
4.07) were observed in patients with pancreatic cancer in comparison to
the control subjects.
Conclusions: This study demonstrates the association between specific
HLA antigens and pancreatic cancer development in whites and suggests a
genetic susceptibility factor for the disease
HLA-A and breast cancer in West Peninsular Malaysia
Breast cancer is the most common malignancy
among females in Malaysia. Attempts have been made to
investigate the association between breast cancer and
human leukocyte antigen (HLA) types. However, data from
those previous studies are highly variable. The aim of this
study is to investigate the association between HLA-A
types and clinicopathological factors in breast cancer. The
frequencies of HLA-A type in 59 female patients with
infiltrating ductal of the breast were determined by polymerase
chain reaction method. HLA-A2/A30 and A2/A31
haplotype (5.1%; P = 0.045) as well as HLA-A30 (5.1%,
P = 0.045) and A31 (6.8%; P = 0.020) allele were significant
higher in the patients than controls (0%). HLAA24
allele was negatively related to lymph node metastasis
(r = -0.316; P = 0.021) whereas, A26 (r = -0.430;
P = 0.001) and A36 (r = -0.430; P = 0.001) alleles were
negatively correlated to distant metastasis in breast cancer.
Negative correlations between HLA-A26/A36 (r =
-0.430; P = 0.001), A2/A11 (r = -0.276; P = 0.044),
A24/A34 (r = -0.430; P = 0.001) haplotypes and distant
metastasis were identified. Interestingly, Her2 expression
in breast carcinoma was negatively correlated to A11/24
haplotypes (r = -0.294; P = 0.034) but positively correlated
to homozygous HLA-A24 (r = 0.396; P = 0.040).
In conclusion, HLA-A2, -A30 and A31 were associated
with breast cancer