108 research outputs found
Π ΠΎΠ»Ρ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΠΈΠ΄ΠΈΠΎΡΠΈΠΏ-Π°Π½ΡΠΈΠΈΠ΄ΠΈΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΡ Π½Π΅Π³Π°ΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ°Π½Π½ΠΈΠΌΠΈ ΡΠΎΡΠΌΠ°ΠΌΠΈ ΡΠΈΡΠΈΠ»ΠΈΡΠ°, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ
Goal. To study the humoral immunity state in patients with the slowed down achievement of negative serologic reactions after the treatment of early onset forms of syphilis by means of examining the blood serum level of idiotypic and anti-idiotypic antibodies to cardiolipin and p17 Treponema Pallidum antigenic protein. Materials and methods. The study involved 324 patients (39.5% male and 60.5% female) with the slowed down achievement of negative serologic reactions. Primary (idiotypic) antibodies to cardiolipin and p17 protein were obtained using immunochromatographic assays with the help of the Bio Logik LP system. Purified antibodies were concentrated using the ultrafiltration technique with the aid of the XM-100Π membrane. To obtain the rabbit antiserum to p17 Treponema Pallidum protein, chinchilla rabbits were immunized using the commercial recombinant p17 protein. To determine anti-cardiolipin idiotypic antibodies in the blood serum, the ELISa method optimized for detecting anti-cardiolipin antibodies was applied. To determine anti-cardiolipin anti-idiotypic antibodies as well as idiotypic and anti-idiotypic antibodies to p17 Treponema Pallidum protein, the standard ELISA method was applied. The following antigens were used to process the pads: F(ab)2 fragments of anti-cardiolipin antibodies (5 ΞΌg/mL), recombinant Ρ17 T. pallidum protein (5 ΞΌg/mL) and F(ab)2 fragments of antibodies to Ρ17 T. pallidum protein (10 ΞΌg/mL). The level of antibodies was assessed based on the absorbancy and expressed in conventional activity units using the K coefficient being the absorbancy of the serum under examination to the mean absorbancy of control serums ratio. The K value exceeding 1.5 conventional units indicated the increased level of antibodies. Results. Patients with the slowed down achievement of negative serologic reactions demonstrated a selective increase in the level of anti-idiotypic antibodies (AIAB) relative to T. pallidum antigens, cardiolipin and p17 protein, vs. first-order antibodies, which points at abnormal mutual regulation between idiotypic antibodies (IAB) and AIAB; the discovered phenomenon lays the immunochemical basis for the formation of a self-sustaining βvicious circleβ contributing to the induction of high levels of antibodies to treponema antigens even when the pathogen was destroyed.Π¦Π΅Π»Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅Π³Π°ΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΏΠΎΡΠ»Π΅ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π½Π½ΠΈΡ
ΡΠΎΡΠΌ ΡΠΈΡΠΈΠ»ΠΈΡΠ° ΠΏΡΡΠ΅ΠΌ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈΠ΄ΠΈΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
(ΠΠΠ’) ΠΈ Π°Π½ΡΠΈΠΈΠ΄ΠΈΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½ΡΠΈΡΠ΅Π» (ΠΠΠΠ’) ΠΊ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½Ρ ΠΈ Ρ17 Π°Π½ΡΠΈΠ³Π΅Π½Π½ΠΎΠΌΡ Π±Π΅Π»ΠΊΡ Treponema pallidum. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 324 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° (39,5% ΠΌΡΠΆΡΠΈΠ½, 60,5% ΠΆΠ΅Π½ΡΠΈΠ½) Ρ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅Π³Π°ΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ. ΠΠ΅ΡΠ²ΠΈΡΠ½ΡΠ΅ (ΠΈΠ΄ΠΈΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠ΅) Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½Ρ ΠΈ Π±Π΅Π»ΠΊΡ Ρ17 ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ°ΡΡΠΈΠ½Π½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΈΡΡΠ΅ΠΌΡ Bio Logik LP. ΠΡΠΈΡΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ»ΡΡΡΠ°ΡΠΈΠ»ΡΡΡΠ°ΡΠΈΠΈ Π½Π° ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π΅ Π₯Π-100Π. ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΊΡΠΎΠ»ΠΈΡΡΠ΅ΠΉ Π°Π½ΡΠΈΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊ Π±Π΅Π»ΠΊΡ Ρ17 T. pallidum ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΈΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΡ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΠΏΠΎΡΠΎΠ΄Ρ ΡΠΈΠ½ΡΠΈΠ»Π»Π° ΠΊΠΎΠΌΠΌΠ΅ΡΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠΌ Π±Π΅Π»ΠΊΠΎΠΌ Ρ17. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΠΠ’ ΠΊ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½Ρ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° (ΠΠ€Π), ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½ΠΎΠ²ΡΡ
Π°Π½ΡΠΈΡΠ΅Π». ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΠΠΠ’ ΠΊ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½Ρ, ΠΠΠ’ ΠΈ ΠΠΠΠ’ ΠΊ Π°Π½ΡΠΈΠ³Π΅Π½Π½ΠΎΠΌΡ Π±Π΅Π»ΠΊΡ Ρ17 T. pallidum ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΡ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠΈ ΠΠ€Π. ΠΠ»Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΏΠ»Π°Π½ΡΠ΅Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Ρ: F(ab)2-ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½Ρ (5 ΠΌΠΊΠ³/ΠΌΠ»), ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ Ρ17 T. pallidum (5 ΠΌΠΊΠ³/ΠΌΠ») ΠΈ F(ab)2-ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π±Π΅Π»ΠΊΡ Ρ17 T. pallidum (10 ΠΌΠΊΠ³/ΠΌΠ»). Π£ΡΠΎΠ²Π΅Π½Ρ Π°Π½ΡΠΈΡΠ΅Π» ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ (ΠΠ) ΠΈ Π²ΡΡΠ°ΠΆΠ°Π»ΠΈ Π² ΡΡΠ»ΠΎΠ²Π½ΡΡ
Π΅Π΄ΠΈΠ½ΠΈΡΠ°Ρ
Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ (ΡΡΠ». Π΅Π΄.) ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠΎΠΌ Π, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡΠΈΠΌ ΡΠΎΠ±ΠΎΠΉ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΠ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊ ΡΡΠ΅Π΄Π½Π΅ΠΌΡ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΠ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΡΡΠ²ΠΎΡΠΎΡΠΎΠΊ. Π Π½Π°Π»ΠΈΡΠΈΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π°Π½ΡΠΈΡΠ΅Π» ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π, ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠ΅Π΅ 1,5 ΡΡΠ». Π΅Π΄. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΠ΅ΠΌ Π½Π΅Π³Π°ΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ ΠΈΠ·Π±ΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΠΠΠΠ’ ΠΊ Π°Π½ΡΠΈΠ³Π΅Π½Π°ΠΌ T. pallidum - ΠΊΠ°ΡΠ΄ΠΈΠΎΠ»ΠΈΠΏΠΈΠ½Ρ ΠΈ Π±Π΅Π»ΠΊΡ Ρ17 - ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΄ΠΊΠ°, ΡΡΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠ½ΠΎΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΠΠ’ ΠΈ ΠΠΠΠ’; Π²ΡΡΠ²Π»Π΅Π½Π½ΡΠΉ ΡΠ΅Π½ΠΎΠΌΠ΅Π½ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΡΠ½ΠΎΠ²ΠΎΠΉ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΌΠΎΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡΠ΅Π³ΠΎΡΡ Β«ΠΏΠΎΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΡΡΠ³Π°Β», ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π°Π½ΡΠΈΠ³Π΅Π½Π°ΠΌ ΡΡΠ΅ΠΏΠΎΠ½Π΅ΠΌΡ Π΄Π°ΠΆΠ΅ ΠΏΠΎΡΠ»Π΅ ΡΡΡΡΠ°Π½Π΅Π½ΠΈΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Ρ
Selection of collector composition and temperature conditions for diamond foam separation
Quantitative and qualitative regularities of a collector low and high molecular weight fractions distribution between solid and liquid phases in foam separation process were determined with the use of extraction-spectrophotometrical technique. The feasibility of producing a collector with optimal ratio of fractions of light distillates, hydrocarbon oils, resin, and asphaltenes by mixing M-40 fuel oil with diesel fuel oil in specified ratios was substantiated. It was shown that applying compound collectors with M-40 fuel oil weight percentage of 60-70 enabled increasing diamond recovery by 2.7-3.5%. Similar increase was also achieved when using F-5 bunker fuel oil diluted by 10-18% with diesel oil fraction. The optimal temperature of 24 Β°C for initial ore feed conditioning with flotation agents and foam separation providing maximum diamond recovery into concentrate and high selectivity was determined. The proposed collectors and temperature conditions enabled increasing diamond recovery
Dynamical Systems Gradient method for solving nonlinear equations with monotone operators
A version of the Dynamical Systems Gradient Method for solving ill-posed
nonlinear monotone operator equations is studied in this paper. A discrepancy
principle is proposed and justified. A numerical experiment was carried out
with the new stopping rule. Numerical experiments show that the proposed
stopping rule is efficient. Equations with monotone operators are of interest
in many applications.Comment: 2 figure
Performance of a fine-sampling electromagnetic calorimeter prototype in the energy range from 1 to 19 GeV
The fine-sampling electromagnetic calorimeter prototype has been
experimentally tested using the 1-19 GeV/c tagged beams of negatively charged
particles at the U70 accelerator at IHEP, Protvino. The energy resolution
measured by electrons is Delta{E}/E=2.8%/\sqrt{E} + 1.3%. The position
resolution for electrons is Delta{x}=3.1 + 15.4/sqrt{E} mm in the center of the
cell. The lateral non-uniformity of the prototype energy response to electrons
and MIPs has turned out to be negligible. Obtained experimental results are in
a good agreement with Monte-Carlo simulations.Comment: Article is prepared for pdflatex using the class elsart. 13 pages, 9
figures in 11 PDF file
Characteristic properties of Planacon MCP-PMTs
A systematic investigation of Planacon MCP-PMTs was performed using 64 XP85002/ FIT-Q photosensors. These devices are equipped with microchannel plates of reduced resistance. Results of a study of their gain stability over time and saturation level in terms of the average anode current are presented. This information allows one to determine the lower limit of the MCP resistance for stable Planacon operation. The spread of the electron multiplication characteristics for the entire production batch is also presented, indicating the remarkably low voltage requirements of these MCP-PMTs. Detection efficiency and noise characteristics, such as dark count rate and afterpulsing level, are also reviewed.Peer reviewe
Measurement of and between 3.12 and 3.72 GeV at the KEDR detector
Using the KEDR detector at the VEPP-4M collider, we have measured
the values of and at seven points of the center-of-mass
energy between 3.12 and 3.72 GeV. The total achieved accuracy is about or
better than at most of energy points with a systematic uncertainty of
about . At the moment it is the most accurate measurement of in
this energy range
New precise determination of the \tau lepton mass at KEDR detector
The status of the experiment on the precise lepton mass measurement
running at the VEPP-4M collider with the KEDR detector is reported. The mass
value is evaluated from the cross section behaviour around the
production threshold. The preliminary result based on 6.7 pb of data is
MeV. Using 0.8 pb of data
collected at the peak the preliminary result is also obtained:
eV.Comment: 6 pages, 8 figures; The 9th International Workshop on Tau-Lepton
Physics, Tau0
Measurement of \Gamma_{ee}(J/\psi)*Br(J/\psi->e^+e^-) and \Gamma_{ee}(J/\psi)*Br(J/\psi->\mu^+\mu^-)
The products of the electron width of the J/\psi meson and the branching
fraction of its decays to the lepton pairs were measured using data from the
KEDR experiment at the VEPP-4M electron-positron collider. The results are
\Gamma_{ee}(J/\psi)*Br(J/\psi->e^+e^-)=(0.3323\pm0.0064\pm0.0048) keV,
\Gamma_{ee}(J/\psi)*Br(J/\psi->\mu^+\mu^-)=(0.3318\pm0.0052\pm0.0063) keV.
Their combinations
\Gamma_{ee}\times(\Gamma_{ee}+\Gamma_{\mu\mu})/\Gamma=(0.6641\pm0.0082\pm0.0100)
keV,
\Gamma_{ee}/\Gamma_{\mu\mu}=1.002\pm0.021\pm0.013 can be used to improve
theaccuracy of the leptonic and full widths and test leptonic universality.
Assuming e\mu universality and using the world average value of the lepton
branching fraction, we also determine the leptonic \Gamma_{ll}=5.59\pm0.12 keV
and total \Gamma=94.1\pm2.7 keV widths of the J/\psi meson.Comment: 7 pages, 6 figure
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