KAJIAN AKTIVITAS PENYEMBUHAN LUKA DAN ANTIBAKTERI BINAHONG (Anredera cordifolia (Ten.) STEENIS, PEGAGAN (Centella asiatica (L.) Urban) SERTA KOMBINASINYA TERHADAP BAKTERI Staphylococcus aureus DAN Pseudomonas aeruginosa DARI PASIEN LUKA KAKI DIABETES

Telah dilakukan uji aktivitas antibakteri ekstrak daunbinahong (Anredera cordifolia (Ten.) Steenis, pegagan(Centella asiatica (L.) Urban) serta kombinasinya. Hasilyang diperoleh menunjukkan bahwa ekstrak binahong,ekstrak pegagan, serta ekstrak kombinasinya padamasing-masing konsentrasi mempunyai aktivitassebagai bakteriostatik terhadap bakteri Staphylococcusaureus dan bakterisidal terhadap Pseudomonas aeroginosa.Kata kunci: Binahong, pegagan, Antibakteri, S. aureus,P. aeruginos

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.*

The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. (RPL), a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride (CCl4)-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels caused by CCl4 intoxication. It also significantly prevented the decrease in superoxide dismutase (SOD) activity and the increase in malondialdehyde (MDA) content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL