On the possibility of obtaining the elastic and biocompatible film materials based on chitosan and N-succinyl chitosan

For the first time, the studies of polyhydric alcohols (glycerol, ethylene glycol and propylene glycol) impact on the structure, deformation–strength characteristics and hemocompatibility of the film materials based on chitosan and N-succinyl chitosan were carried out. It was shown that the introduction of polyhydric alcohols into molding solutions during the creation of the films based on chitosan and succinyl chitosan in the amount up to 0.05 mol/l is accompanied by the tensile elongation value increase by 2–2.5 times. The value of the breaking stress in this case decreases by 3–4 times. There is also a decrease in the overall surface roughness and a sharp drop in the elastic modulus of the films. The stabilizing impact of the systems based on chitosan and succinyl chitosan in the presence of glycerol and propylene glycol upon the cell membranes in physiological conditions allows inferring their high hemocompatibility

Влияние пандемии COVID-19 на инфекционную заболеваемость у детей в условиях мегаполиса

In the work, based on a retrospective analysis of the medical documentation of a children's clinic for 2017—2022. the impact of the COVID-19 pandemic on in- fectious morbidity in children was assessed. The data obtained indicate that in the children's population of St. Petersburg, as well as throughout the world, along with low involvement in the epidemic process of a new coronavirus infection, the incidence of seasonal acute respiratory and intestinal infections, chicken pox, scarlet fever, and whooping cough has significantly decreased. The COVID-19 pandemic did not have a significant impact on the structure and seasonality of in- fectious diseases in children. The phased exit from the lockdown did not lead to the predicted explosive growth of seasonal infections — as restrictions were eased, the incidence of acute respiratory and intestinal infections over the past two years has smoothly returned to pre-pandemic levels.В работе на основе ретроспективного анализа медицинской документации детской поликлиники за 2017—2022 гг. проведена оценка влияния пандемии COVID-19 на инфекционную заболеваемость у детей. Полученные данные свидетельствуют о том, что в детской популяции Санкт-Петербурга, как и во всем мире, наряду с низкой вовлеченностью в эпидемический процесс по новой коронавирусной инфекции, значительно снизилась заболеваемость сезонными острыми респираторными и кишечными инфекциями, ветряной оспой, скарлатиной, коклюшем. Пандемия COVID-19 не оказала существенного влияния на структуру и сезонность инфекционных заболеваний у детей. Поэтапный выход из локдауна не привел к прогнозируемому взрывному росту сезонных инфекций — по мере смягчения ограничений заболеваемость острыми респираторными и кишечными инфекциями в течение двух последних лет плавно вернулась к допандемическому уровню