35 research outputs found
Π Π΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎ-ΡΠΈΠ½ΡΠΈΡΠΈΠ°Π»ΡΠ½Π°Ρ Π²ΠΈΡΡΡΠ½Π°Ρ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ. Π ΠΎΠ»Ρ Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ
Acute respiratory infections (ARI) consistently occupy a leading place in the structure of infectious pathology, especially among children. The spectrum of pathogens is usually determined by the season and age aspect of the observed. In a large number of respiratory viruses, respiratory syncytial virus (RSV) occupies a special place due to the variety and severity of clinical manifestations of the disease caused by it in young children. This article is devoted to the analysis of the clinical course of RSV infection in children, the study of the features of the immune status against the background of this disease.It was found that in most cases of RSV infection in children was characterized by signs of bronchial obstruction syndrome and as a consequence in this group of children were found to have dysfunction of the immune system and reduction in the total number of T-lymphocytes, the hyperactivation In-cell component of adaptive immunity, manifested disimmunoglobulinemia (increase in the content of total IgE at lower IgA and IgG), that is, with the formation of immunodeficiency states from T- and B-cell links of adaptive immunity, with long-term recovery of impaired performance, even against the background of effective antiviral therapy.ΠΡΡΡΡΠ΅ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ (ΠΠ Π) Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π½ΠΎ Π·Π°Π½ΠΈΠΌΠ°ΡΡ Π²Π΅Π΄ΡΡΠ΅Π΅ ΠΌΠ΅ΡΡΠΎ Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΡΠ΅Π΄ΠΈ Π΄Π΅ΡΠ΅ΠΉ. Π‘ΠΏΠ΅ΠΊΡΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ ΡΠ΅Π·ΠΎΠ½ΠΎΠΌ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΠΌ Π°ΡΠΏΠ΅ΠΊΡΠΎΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΠΌΡΡ
. Π ΠΌΠ½ΠΎΠ³ΠΎΡΠΈΡΠ»Π΅Π½Π½ΠΎΠΌ ΡΡΠ΄Ρ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΡ
Π²ΠΈΡΡΡΠΎΠ², ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎ-ΡΠΈΠ½ΡΠΈΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π²ΠΈΡΡΡ (Π Π‘Π) Π·Π°Π½ΠΈΠΌΠ°Π΅Ρ ΠΎΡΠΎΠ±ΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ Π² ΡΠ²ΡΠ·ΠΈ Ρ ΠΌΠ½ΠΎΠ³ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ΠΌ ΠΈ ΡΡΠΆΠ΅ΡΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΠΎΠΉ ΠΈΠΌ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. ΠΠ°Π½Π½Π°Ρ ΡΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π°Π½Π°Π»ΠΈΠ·Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π Π‘Π ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ, ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° Π½Π° ΡΠΎΠ½Π΅ Π΄Π°Π½Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ.ΠΡΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² Π Π‘Π ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π»Π° Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Π±ΡΠΎΠ½Ρ
ΠΎΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΠΈ ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ Ρ Π΄Π°Π½Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π΄Π΅ΡΠ΅ΠΉ Π±ΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π² Π²ΠΈΠ΄Π΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², Π³ΠΈΠΏΠ΅ΡΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π·Π²Π΅Π½Π° Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, ΠΏΡΠΎΡΠ²Π»ΡΡΡΠ΅ΠΉΡΡ Π΄ΠΈΡΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ΅ΠΌΠΈΠ΅ΠΉ (ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΎΠ±ΡΠ΅Π³ΠΎ IgΠ ΠΏΡΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠΈ IgA ΠΈ IgG), ΡΠΎ Π΅ΡΡΡ Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠΌΡΠ½ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠΎ ΡΡΠΎΡΠΎΠ½Ρ Π’- ΠΈ Π-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π·Π²Π΅Π½ΡΠ΅Π² Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ Π½Π°ΡΡΡΠ΅Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, Π΄Π°ΠΆΠ΅ Π½Π° ΡΠΎΠ½Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΈΡΡΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΈΡ ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° Π±ΠΎΠ»ΡΠ½ΡΡ Π±ΡΠΎΠ½Ρ ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ Ρ Π°Π»Π΅ΠΊΡΠΈΡΠΈΠΌΠΈΠ΅ΠΉ
One hundred and eighteen bronchial asthma (BA) patients were examined by means of the Toronto alexithymie scale (TAS), and a brief version of the personality multilateral investigation method (PMIM), and the Spilberg-Khaninβs anxiety scale. Among them 55.1% of the patients were recognized as alexithymie persons. Asthmatic patients with alexithymia were reliably more neurotized compared with non-alexithymic ones. The revealed peculiarities of an actual personal condition of the alexithymie bronchial asthma patients cause a necessity of including methods of psychotherapeutic correction of alexithymia to a prevention measures system.ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 118 Π±ΠΎΠ»ΡΠ½ΡΡ
Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ (ΠΠ) Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π’ΠΎΡΠΎΠ½ΡΡΠΊΠΎΠΉ Π°ΠΏΠ΅ΠΊΡΠΈΡΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΊΠ°Π»Ρ (TAS), ΡΠΎΠΊΡΠ°ΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ ΠΌΠ½ΠΎΠ³ΠΎΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π»ΠΈΡΠ½ΠΎΡΡΠΈ (Π‘ΠΠΠ), ΡΠΊΠ°Π»Ρ ΡΡΠ΅Π²ΠΎΠ³ΠΈ Π‘ΠΏΠΈΠ»Π±Π΅ΡΠ³Π°-Π₯Π°Π½ΠΈΠ½Π°. ΠΠ»Π΅ΠΊΡΠΈΡΠΈΠΌΠΈΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°Π½Ρ 55,1% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ. ΠΠΎΠ»ΡΠ½ΡΠ΅ ΠΠ Ρ Π°Π»Π΅ΠΊΡΠΈΡΠΈΠΌΠΈΠ΅ΠΉ ΠΈΠΌΠ΅Π»ΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π½Π΅Π²ΡΠΎΡΠΈΠ·Π°ΡΠΈΠΈ Π»ΠΈΡΠ½ΠΎΡΡΠΈ, ΡΠ΅ΠΌ Π½Π΅Π°Π»Π΅ΠΊΡΠΈΡΠΈΠΌΠΈΡΠ½ΡΠ΅ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄Ρ. ΠΡΡΠ²Π»Π΅Π½Π½ΡΠ΅ Π½Π°ΠΌΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π»ΠΈΡΠ½ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π°Π»Π΅ΠΊΡΠΈΡΠΈΠΌΠΈΡΠ½ΡΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ ΠΎΠ±ΡΡΠ»Π°Π²Π»ΠΈΠ²Π°ΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΈΡ Π² ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΈΡ
ΠΎΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ Π°Π»Π΅ΠΊΡΠΈΡΠΈΠΌΠΈΠΈ
Respiratory syncytial viral infection in children. Role in the structure of respiratory pathology and clinical and immunological features
Acute respiratory infections (ARI) consistently occupy a leading place in the structure of infectious pathology, especially among children. The spectrum of pathogens is usually determined by the season and age aspect of the observed. In a large number of respiratory viruses, respiratory syncytial virus (RSV) occupies a special place due to the variety and severity of clinical manifestations of the disease caused by it in young children. This article is devoted to the analysis of the clinical course of RSV infection in children, the study of the features of the immune status against the background of this disease.It was found that in most cases of RSV infection in children was characterized by signs of bronchial obstruction syndrome and as a consequence in this group of children were found to have dysfunction of the immune system and reduction in the total number of T-lymphocytes, the hyperactivation In-cell component of adaptive immunity, manifested disimmunoglobulinemia (increase in the content of total IgE at lower IgA and IgG), that is, with the formation of immunodeficiency states from T- and B-cell links of adaptive immunity, with long-term recovery of impaired performance, even against the background of effective antiviral therapy
Early vascular remodeling role in arterial hypertension pathogenesis among young patients
Aim. To investigate vascular wall stiffness in young patients, for examining early vascular remodeling role in arterial hypertension (AH) pathogenesis in young age. Material and methods. The study included 291 individuals: 169 normotensives and 122 AH patients aged 16-34 years. All participants underwent volume sphygmography (VaSera-1000, Β«Fukuda DenshiΒ», Japan), blood pressure (BP) measurement in upper and lower extremity basins, elastic and muscular vessel elasticity assessment. Results. In young age, high elastic vessel stiffness was observed in 13.6% of normotensives, and in 50% of AH patients. For muscular vessels, this parameter was 11.2% and 35%, respectively. In systolo-diastolic AH, muscular vessel stiffness increased, in isolated systolic AH (ISAH) β elastic or elastic and muscular vessel stiffness is increased. About 50% of young ISAH individuals had increased BP on upper extremities only β Β«pseudo-hypertensionΒ». Conclusion. Early vascular remodeling plays an important role in AH pathogenesis among young people
FEATURES OF INITIATION OF STYRENE POLYMERIZATION BY CUMENE HYDROPEROXIDE IN PRESENCE OF ACETULACETONATE OF COPPER(II)
Kinetics of sectional styrene polymerization initiated by cumene hydroperoxide, acetylacetonate of copper(II) and by the system of cumene hydroperoxide β acetylacetonate of copper(II) in a temperature range 333-363 K is studied. Kinetic parameters of polymerization process are determined. It is shown, that system of cumene hydroperoxide β acetylacetonate of copper(II) is in 5-6 times more effective on the initiating ability comparatively to application of its individual components. From findings ensues that decline of energy of activating of initiation from 110 kdzh/molβ to 87 kdzh/molβ for cumene hydroperoxide at the use of the studied system is caused with participating of monomer in preliminary complexation facilitating formation of free radicals
NEW INITIATOR SYSTEMS FOR POLYMERIZATION OF VINYL MONOMERS TERTIARY HYDROPEROXIDES β COMPLEX OF COPPER(II) CHLORIDE WITH PIPERIDIN-1-YL PIPERIDINE-1-CARBODITHIOATE
Kinetics of polymerization of styrene in-bulk initiated by tertiary hydroperoxides
of butyl and cumene, by the complex of copper(II) chloride with piperidin-1-yl piperidine-1-carbodithioate and systems on their basis in a temperature range 293β363 K is studied. The kinetic parameters of polymerization process are determined. It is set that application of the double-base systems tertiary hydroperoxides β complex of copper(II) chloride with piperidin-1-yl piperidine-1-carbodithioate for polymerization of styrene is accompanied by the substantial decline of energy of activation of initiating
Clinical and immunological analysis of the effectiveness of local application of vitamin D<sub>3</sub> in experimental colitis
The pathogenesis of inflammatory bowel diseases has not been fully studied, and the therapies used have side effects that limit their use.The purpose of this study is to conduct a clinical and immunological analysis of the effectiveness of vitamin D3 in the original rectal suppositories in experimental colitis (EC).EC was modeled with oxazolone. Original suppositories with vitamin D3 in group 3 and 5-ASA in group 4 were used per rectum. The clinic was evaluated on the Disease activity index scale. The expression of MPO and TNFa, the content of neutrophils, lymphocytes, eosinophils, histiocytes, plasmocytes, fibroblasts, ulcerative defect, tissue damage index were determined in the focus of colon injury. The study was carried out on days 2, 4 and 6.With EC, DAI increases for the entire day, MPO and TNFa increase in the lesion, ulcerative defect isfixed, neutrophil-lymphocytic infiltration increases, and TDI increases. When comparing the morphometric parameters of the alteration zone in EC under the conditions of vitamin D3 use, in contrast to the use of 5-ASA, a decrease in the number of lymphocytes, an increase in fibroblasts was revealed on day 2, a decrease in the number of plasmocytes and an increase in fibroblasts on day 4, an increase in the number of histiocytes and fibroblasts on day 6. The diameter of the ulcerative defect and the TDI index have no significant differences between the compared groups. When comparing the effectiveness of vitamin D3, in contrast to the use of 5-ASA, the MPO content is higher on day 6; the TNFa content is higher on day 4.In EC, the effects of using rectal suppositories with vitamin D3 on clinical signs, the size of the ulcerative defect, the content of MPO and TNFa in the lesion are comparable to the effects of using rectal suppositories with 50 mg of 5-ASA; more pronounced with respect to the dynamics of the cellular composition of the lesion of the colon
Linear reduced cosserat medium with spherical tensor of inertia, where rotations are not observed in experiment
Formation of concentration profiles of implanted ions in metallic materials under polyenergetic implantation
The new differential diagnostic test for the lichenoid drug eruption
The differential diagnosis between lichenoid drug eruption (LDE) and lichen planus (LP) is difficult due to similar clinical and histological signs, but important for treatment and prognosis. The purpose of this study was to propose the new diagnosis method for differentiate LDE from lichen planus. During 2015-2018, 20 patients with confirmed LDE, 13 patients with LP and 134 controls were examined and treated at the Lenoblcenter. All enrolled patients were underwent the injection of 0.5βmL of the 2% lidocaine solution by insulin syringe into the papule with following histological examination. The formation of a blister (bulla) at the site of injection was considered a positive test result. Among LDE 18/20 patients were found positive for developing blister (bulla), 2 results were questionable. In 12 of 13 LP patents, bulla on the site of injection was not identified, the result of 1 patient was non-specific. All control patients were negative for the proposed test. The histological sections showed that the bulla has corresponded to the separation of the epidermis from the dermis. Intracutaneous injection of 0.5βmL of lidocaine into the papule is an easy highly specific and sensitive method to differentiate LDE from LP. This article is protected by copyright. All rights reserved