477 research outputs found
Vacuum effects in an asymptotically uniformly accelerated frame with a constant magnetic field
In the present article we solve the Dirac-Pauli and Klein Gordon equations in
an asymptotically uniformly accelerated frame when a constant magnetic field is
present. We compute, via the Bogoliubov coefficients, the density of scalar and
spin 1/2 particles created. We discuss the role played by the magnetic field
and the thermal character of the spectrum.Comment: 17 pages. RevTe
Field induced evolution of regular and random 2D domain structures and shape of isolated domains in LiNbO<sub>3</sub> and LiTaO<sub>3</sub>
The shapes of isolated domains produced by application of the uniform external electric field in different experimental conditions were investigated experimentally in single crystalline lithium niobate LiNbO3 and lithium tantalate LiTaO3. The study of the domain kinetics by computer simulation and experimentally by polarization reversal of the model structure using two-dimensional regular electrode pattern confirms applicability of the kinetic approach to explanation of the experimentally observed evolution of the domain shape and geometry of the domain structure. It has been shown that the fast domain walls strictly oriented along X directions appear after domain merging
One-pot three-component synthesis of 3-cyano-4-methyl-2,6-dioxopyridine amino enones
(Z)-5-(Arylaminomethylidene)-4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitriles were obtained by three-component condensation of 4-methyl-2,6-dioxo-1,2,5,6-tetrahydropyridine-3-carbonitrile with aromatic amines and trimethyl orthoformate in DMF. According to X-ray data, in the solid phase they exist as amino enone tautomer
Circulating Marangoni flows within droplets in smectic films
We present theoretical study and numerical simulation of Marangoni convection
within ellipsoidal isotropic droplets embedded in free standing smectic films
(FSSF). The thermocapillary flows are analyzed for both isotropic droplets
spontaneously formed in FSSF overheated above the bulk smectic-isotropic
transition, and oil lenses deposited on the surface of the smectic film. The
realistic model, for which the upper drop interface is free from the smectic
layers, while at the lower drop surface the smectic layering still persists is
considered in detail. For isotropic droplets and oil lenses this leads
effectively to a sticking of fluid motion at the border with a smectic shell.
The above mentioned asymmetric configuration is realized experimentally when
the temperature of the upper side of the film is higher than at the lower one.
The full set of stationary solutions for Stokes stream functions describing the
Marangoni convection flows within the ellipsoidal drops were derived
analytically. The temperature distribution in the ellipsoidal drop and the
surrounding air was determined in the frames of the perturbation theory. As a
result the analytical solutions for the stationary thermocapillary convection
were derived for different droplet ellipticity ratios and the heat conductivity
of the liquid crystal and air. In parallel, the numerical hydrodynamic
calculations of the thermocapillary motion in the drops were performed. Both
the analytical and numerical simulations predict the axially-symmetric
circulatory convection motion determined by the Marangoni effect at the droplet
free surface. Due to a curvature of the drop interface a temperature gradient
along its free surface always persists. Thus, the thermocapillary convection
within the ellipsoidal droplets in overheated FSSF is possible for the
arbitrarily small Marangoni numbers
ΠΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ 3-(2-Π°ΠΌΡΠ½ΠΎΡΠ΅Π½ΡΠ»)-6-R-1,2,4-ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½ΡΠ² ΡΠ° ΡΠΈΠΊΠ»ΡΡΠ½ΠΈΡ Π°Π½Π³ΡΠ΄ΡΠΈΠ΄ΡΠ² Π½Π΅ΡΠΈΠΌΠ΅ΡΡΠΈΡΠ½ΠΈΡ Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ ΠΊΠΈΡΠ»ΠΎΡ
The peculiarities of the reaction between 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones and cyclic anhydrides of non-symmetric (2-methylsuccinic, 2-phenylsuccinic and camphoric) acids have been described in the present article. The influence of electronic and steric effects of substituents in the anhydride molecule on cyclisation processes has been discussed. The results have shown that the interaction of 3-(2-aminophenyl)-6-R-1,2,4-triazin- 5(2H)-ones mentioned above with 2-methylsuccinic and 2-phenylsuccinic acid anhydrides proceeded non-selectively and yielded the mixtures of 2-R1-3-(2-oxo-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)propanoic acids and 1-(2-(5-oxo-6-R-2,5-dihydro-1,2,4-triazin-3-yl)phenyl)-3-R1-pyrrolidine-2,5-diones. It has been found that low regioselectivity of the acylation process may be explained by insignificant electronic effects of substituents (of the methyl and phenyl fragment) in position 2 of the anhydride molecule on the electrophilic reaction centre. It has been also determined that the reaction between 3-(2-aminophenyl)-6-R-1,2,4-triazin-5(2H)-ones and camphoric anhydride proceeds regioselectively and yielded 1,2,2-trimethyl-3-(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin- 6-yl)cyclopentan-1-carboxylic acids. Regioselectivity of the interaction mentioned above may be explained by the steric effect of the methyl group. Identity of compounds has been proven by LC-MS, the structure has been determined via a set of characteristic signals in 1H NMR, 13C NMR spectra and position of cross peaks in the correlation HSQC-experiment. Mass spectra of the compounds synthesized have been also studied, the principal directions of the molecule fragmentation have been described. The structure of 1,2,2-trimethyl-3-(3-methyl- 2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)cyclopentane-1-carboxylic acid has been proven by X-ray analysis.ΠΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ 3-(2-Π°ΠΌΠΈΠ½ΠΎΡΠ΅Π½ΠΈΠ»)-6-R-1,2,4-ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½Π°ΠΌΠΈ ΠΈ Π°Π½Π³ΠΈΠ΄ΡΠΈΠ΄Π°ΠΌΠΈ Π½Π΅ΡΠΈΠΌΠΌΠ΅ΡΡΠΈΡΠ½ΡΡ
Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ (2-ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΡΠ°ΡΠ½ΠΎΠΉ, 2-ΡΠ΅Π½ΠΈΠ»ΡΠ½ΡΠ°ΡΠ½ΠΎΠΉ ΠΈ ΠΊΠ°ΠΌΡΠΎΡΠ½ΠΎΠΉ) ΠΊΠΈΡΠ»ΠΎΡ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ
ΠΈ ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ Π½Π° ΠΏΡΠΎΡΠ΅ΡΡΡ ΡΠΈΠΊ- Π»ΠΈΠ·Π°ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΡΡ
Π²ΡΡΠ΅ 3-(2-Π°ΠΌΠΈΠ½ΠΎΡΠ΅Π½ΠΈΠ»)-6-R-1,2,4- ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½ΠΎΠ² Ρ Π°Π½Π³ΠΈΠ΄ΡΠΈΠ΄Π°ΠΌΠΈ 2-ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΡΠ°ΡΠ½ΠΎΠΉ ΠΈ 2-ΡΠ΅Π½ΠΈΠ»ΡΠ½ΡΠ°ΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π»ΠΎ Π½Π΅ ΡΠ΅Π³ΠΈΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎ Ρ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠΌΠ΅ΡΠ΅ΠΉ 2-R 1-3-(2-ΠΎΠΊΡΠΎ-3-R-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½-6-ΠΈΠ»)ΠΏΡΠΎ- ΠΏΠ°Π½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΈ 1-(2-(5-ΠΎΠΊΡΠΎ-6-R-2,5-Π΄ΠΈΠ³ΠΈΠ΄ΡΠΎ-1,2,4ΡΡΠΈΠ°Π·ΠΈΠ½-3-ΠΈΠ»)ΡΠ΅Π½ΠΈΠ»)-3-R1-ΠΏΠΈΡΠΎΠ»ΠΈΠ΄ΠΈΠ½-2,5-Π΄ΠΈΠΎΠ½ΠΎΠ². ΠΠΎ- ΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½ΠΈΠ·ΠΊΠ°Ρ ΡΠ΅Π³ΠΈΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠ° Π°ΡΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΠ±ΡΡΡΠ½Π΅Π½Π° Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΌΠΈ ΡΡΡΠ΅ΠΊΡΠ°ΠΌΠΈ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΉ (ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠ΅Π½ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°) Π² ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΠΈ 2 ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Π°Π½Π³ΠΈΠ΄ΡΠΈΠ΄Π° Π½Π° ΡΠ»Π΅ΠΊΡΡΠΎΡΠΈΠ»ΡΠ½ΡΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΡΠΉ ΡΠ΅Π½ΡΡ. Π’Π°ΠΊΠΆΠ΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ΅Π°ΠΊΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ 3-(2-Π°ΠΌΠΈΠ½ΠΎΡΠ΅Π½ΠΈΠ»)-6-R-1,2,4-ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½Π°ΠΌΠΈ ΠΈ Π°Π½Π³ΠΈΠ΄ΡΠΈΠ΄ΠΎΠΌ ΠΊΠ°ΠΌΡΠΎΡΠ½ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π΅Ρ ΡΠ΅Π³ΠΈΠΎ- ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ 1,2,2-ΡΡΠΈΠΌΠ΅ΡΠΈΠ»-3-(3-R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½- 6-ΠΈΠ»)ΡΠΈΠΊΠ»ΠΎΠΏΠ΅Π½ΡΠ°Π½-1-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ. Π‘Π΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π² Π΄Π°Π½Π½ΠΎΠΌ ΡΠ»ΡΡΠ°Π΅ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΠ±ΡΡΡΠ½Π΅Π½Π° ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΡΡΠ΅ΠΊΡΠΎΠΌ ΠΌΠ΅ΡΠΈΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ. ΠΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΠΌΠ΅- ΡΠΎΠ΄Π°ΠΌΠΈ LC-MS, ΡΡΡΡΠΊΡΡΡΡ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΏΠΎ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠ³Π½Π°Π»ΠΎΠ² Π² 1H Π―ΠΠ ΠΈ 13Π‘ Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΠ°Ρ
ΠΈ ΠΏΠΎ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΠΊΡΠΎΡΡ-ΠΏΠΈΠΊΠΎΠ² Π² ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΌ HSQC-ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅. Π’Π°ΠΊΠΆΠ΅ Π±ΡΠ»ΠΈ ΠΈΡΡΠ»Π΅- Π΄ΠΎΠ²Π°Π½Ρ ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΡ ΡΠΈΠ½ΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΈΠΎΠ½ΠΎΠ². Π‘ΡΡΡΠΊΡΡΡΡ 1,2,2-ΡΡΠΈΠΌΠ΅ΡΠΈΠ»-3-(3-ΠΌΠ΅ΡΠΈΠ»-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΠΈΠ½Π°Π·ΠΎΠ»ΠΈΠ½- 6-ΠΈΠ»)ΡΠΈΠΊΠ»ΠΎΠΏΠ΅Π½ΡΠ°Π½-1-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Π±ΡΠ»ΠΎ Π΄ΠΎΠΊΠ°Π·Π°Π½ΠΎ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°.ΠΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΡΠ΅Π°ΠΊΡΡΡ ΠΌΡΠΆ 3-(2-Π°ΠΌΡΠ½ΠΎΡΠ΅Π½ΡΠ»)-6-R-1,2,4-ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½Π°ΠΌΠΈ Π· Π°Π½Π³ΡΠ΄ΡΠΈΠ΄Π°ΠΌΠΈ Π½Π΅ΡΠΈΠΌΠ΅Ρ- ΡΠΈΡΠ½ΠΈΡ
Π΄ΠΈΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ (2-ΠΌΠ΅ΡΠΈΠ»Π±ΡΡΡΡΠΈΠ½ΠΎΠ²ΠΎΡ, 2-ΡΠ΅Π½ΡΠ»Π±ΡΡΡΡΠΈΠ½ΠΎΠ²ΠΎΡ ΡΠ° ΠΊΠ°ΠΌΡΠΎΡΠ½ΠΎΡ) ΠΊΠΈΡΠ»ΠΎΡ. ΠΠ±Π³ΠΎ- Π²ΠΎΡΠ΅Π½ΠΎ Π²ΠΏΠ»ΠΈΠ² Π΅Π»Π΅ΠΊΡΡΠΎΠ½Π½ΠΈΡ
ΡΠ° ΡΡΠ΅ΡΠΈΡΠ½ΠΈΡ
Π΅ΡΠ΅ΠΊΡΡΠ² Π·Π°ΠΌΡΡΠ½ΠΈΠΊΠ° Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ Π°Π½Π³ΡΠ΄ΡΠΈΠ΄Ρ Π½Π° ΠΏΡΠΎΡΠ΅ΡΠΈ ΡΠΈΠΊΠ»ΡΠ·Π°ΡΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΠΎ Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ Π½Π°Π²Π΅Π΄Π΅Π½ΠΈΡ
Π²ΠΈΡΠ΅ 3-(2-Π°ΠΌΡΠ½ΠΎΡΠ΅Π½ΡΠ»)-6-R-1,2,4-ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½ΡΠ² Π· Π°Π½Π³ΡΠ΄ΡΠΈΠ΄Π°ΠΌΠΈ 2-ΠΌΠ΅ΡΠΈΠ»Π±ΡΡΡΡΠΈΠ½ΠΎΠ²ΠΎΡ ΡΠ° 2-ΡΠ΅Π½ΡΠ»Π±ΡΡΡΡΠΈΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Π°Π»Π° Π½Π΅ΡΠ΅Π³ΡΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎ Π· ΡΡΠ²ΠΎΡΠ΅Π½Π½ΡΠΌ ΡΡΠΌΡΡΡ 2-R1-3-(2-ΠΎΠΊΡΠΎ-3-R-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΠ»)ΠΏΡΠΎΠΏΠ°Π½ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ ΡΠ° 1-(2- (5-ΠΎΠΊΡΠΎ-6-R-2,5-Π΄ΠΈΠ³ΡΠ΄ΡΠΎ-1,2,4ΡΡΠΈΠ°Π·ΠΈΠ½-3-ΡΠ»)ΡΠ΅Π½ΡΠ»)-3-R1-ΠΏΡΡΠΎΠ»ΡΠ΄ΠΈΠ½-2,5-Π΄ΡΠΎΠ½ΡΠ². ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ Π½ΠΈΠ·ΡΠΊΠ° ΡΠ΅Π³ΡΠΎΡΠ΅- Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡ Π°ΡΠΈΠ»ΡΠ²Π°Π½Π½Ρ ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ ΠΏΠΎΡΡΠ½Π΅Π½Π° Π½Π΅Π·Π½Π°ΡΠ½ΠΈΠΌΠΈ Π΅Π»Π΅ΠΊΡΡΠΎΠ½Π½ΠΈΠΌΠΈ Π΅ΡΠ΅ΠΊΡΠ°ΠΌΠΈ Π·Π°ΠΌΡΡΠ½ΠΈΠΊΡΠ² (ΠΌΠ΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ° ΡΠ΅Π½ΡΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΡ) Ρ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½Ρ 2 ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΠΈ Π°Π½Π³ΡΠ΄ΡΠΈΠ΄Ρ Π½Π° Π΅Π»Π΅ΠΊΡΡΠΎΡΡΠ»ΡΠ½ΠΈΠΉ ΡΠ΅Π°ΠΊΡΡΠΉΠ½ΠΈΠΉ ΡΠ΅Π½ΡΡ. Π’Π°ΠΊΠΎΠΆ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΡΠ΅Π°ΠΊΡΡΡ ΠΌΡΠΆ 3-(2-Π°ΠΌΡΠ½ΠΎΡΠ΅Π½ΡΠ»)-6-R-1,2,4-ΡΡΠΈΠ°Π·ΠΈΠ½-5(2H)-ΠΎΠ½Π°ΠΌΠΈ ΡΠ° Π°Π½Π³ΡΠ΄ΡΠΈΠ΄ΠΎΠΌ ΠΊΠ°ΠΌΡΠΎΡΠ½ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Π°Ρ ΡΠ΅Π³ΡΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡ Π΄ΠΎ ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ 1,2,2-ΡΡΠΈΠΌΠ΅ΡΠΈΠ»-3-(3- R-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΠ»)ΡΠΈΠΊΠ»ΠΎΠΏΠ΅Π½ΡΠ°Π½-1-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ. Π‘Π΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π·Π°- Π·Π½Π°ΡΠ΅Π½ΠΎΡ Π²ΠΈΡΠ΅ ΡΠ΅Π°ΠΊΡΡΡ ΠΌΠΎΠΆΠ΅ Π±ΡΡΠΈ ΠΏΠΎΡΡΠ½Π΅Π½Π° ΡΡΠ΅ΡΠΈΡΠ½ΠΈΠΌΠΈ Π΅ΡΠ΅ΠΊΡΠ°ΠΌΠΈ ΠΌΠ΅ΡΠ°Π»ΡΠ½ΠΎΡ Π³ΡΡΠΏΠΈ. ΠΠ½Π΄ΠΈΠ²ΡΠ΄ΡΠ°Π»ΡΠ½ΡΡΡΡ ΡΠΏΠΎΠ»ΡΠΊ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΆΠ΅Π½Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ LC-MS, ΡΡΡΡΠΊΡΡΡΡ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π·Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΠΌ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΡΠ½ΠΈΡ
ΡΠΈΠ³Π½Π°Π»ΡΠ² Ρ 1H Π―ΠΠ ΡΠ° 13Π‘ Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΠ°Ρ
ΡΠ° Π·Π° ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΡΠΌ ΠΊΡΠΎΡ-ΠΏΡΠΊΡΠ² Ρ ΠΊΠΎΡΠ΅Π»ΡΡΡΠΉΠ½ΠΎΠΌΡ HSQC-Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ. Π’Π°ΠΊΠΎΠΆ Π±ΡΠ»ΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ ΠΌΠ°Ρ-ΡΠΏΠ΅ΠΊΡΡΠΈ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠ²Π°Π½ΠΈΡ
ΡΠΏΠΎΠ»ΡΠΊ ΡΠ° ΠΎΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½Ρ Π½Π°ΠΏΡΡΠΌΠΊΠΈ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°ΡΡΡ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΈΡ
ΡΠΎΠ½ΡΠ². Π‘ΡΡΡΠΊΡΡΡΡ 1,2,2-ΡΡΠΈΠΌΠ΅ΡΠΈΠ»-3-(3-ΠΌΠ΅ΡΠΈΠ»-2-ΠΎΠΊΡΠΎ-2H-[1,2,4]ΡΡΠΈΠ°Π·ΠΈΠ½ΠΎ[2,3-c]Ρ
ΡΠ½Π°Π·ΠΎΠ»ΡΠ½-6-ΡΠ») ΡΠΈΠΊΠ»ΠΎΠΏΠ΅Π½ΡΠ°Π½-1-ΠΊΠ°ΡΠ±ΠΎΠ½ΠΎΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π±ΡΠ»ΠΎ Π΄ΠΎΠ²Π΅Π΄Π΅Π½ΠΎ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ
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