Hydrological model calibration for derived flood frequency analysis using stochastic rainfall and probability distributions of peak flows

Derived flood frequency analysis allows the estimation of design floods with hydrological modeling for poorly observed basins considering change and taking into account flood protection measures. There are several possible choices regarding precipitation input, discharge output and consequently the calibration of the model. The objective of this study is to compare different calibration strategies for a hydrological model considering various types of rainfall input and runoff output data sets and to propose the most suitable approach. Event based and continuous, observed hourly rainfall data as well as disaggregated daily rainfall and stochastically generated hourly rainfall data are used as input for the model. As output, short hourly and longer daily continuous flow time series as well as probability distributions of annual maximum peak flow series are employed. The performance of the strategies is evaluated using the obtained different model parameter sets for continuous simulation of discharge in an independent validation period and by comparing the model derived flood frequency distributions with the observed one. The investigations are carried out for three mesoscale catchments in northern Germany with the hydrological model HEC-HMS (Hydrologic Engineering Center's Hydrologic Modeling System). The results show that (I) the same type of precipitation input data should be used for calibration and application of the hydrological model, (II) a model calibrated using a small sample of extreme values works quite well for the simulation of continuous time series with moderate length but not vice versa, and (III) the best performance with small uncertainty is obtained when stochastic precipitation data and the observed probability distribution of peak flows are used for model calibration. This outcome suggests to calibrate a hydrological model directly on probability distributions of observed peak flows using stochastic rainfall as input if its purpose is the application for derived flood frequency analysis

Stem cell biology meets systems biology

Stem cells and their descendents are the building blocks of life. How stem cell populations guarantee their maintenance and/or self-renewal, and how individual stem cells decide to transit from one cell stage to another to generate different cell types are long-standing and fascinating questions in the field. Here, we review the discussions that took place at a recent EMBO conference in Cambridge, UK, in which these questions were placed in the context of the latest advances in stem cell biology in presentations that covered stem cell heterogeneity, cell fate decision-making, induced pluripotency, as well as the mathematical modelling of these phenomena

Spontaneous spin polarization in doped semiconductor quantum wells

We calculate the critical density of the zero-temperature, first-order ferromagnetic phase transition in n-doped GaAs/AlGaAs quantum wells. We find that the existence of the ferromagnetic transition is dependent upon the choice of well width. We demonstrate rigorously that this dependence is governed by the interplay between different components of the exchange interaction and that there exists an upper limit for the well width beyond which there is no transition. We predict that some narrow quantum wells could exhibit this transition at electron densities lower than the ones that have been considered experimentally thus far. We use a screened Hartree-Fock approximation with a polarization-dependent effective mass, which is adjusted to match the critical density predicted by Monte Carlo calculations for the two-dimensional electron gas.Comment: Submitted to Eur. Phys. Journal

Disorder Effects in Superconductors with Anisotropic Pairing: From Cooper Pairs to Compact Bosons

In the weak coupling BCS-approximation normal impurities do not influence superconducting T_{c} in significant manner in case of isotropic s-wave pairing. However, in case of d-wave pairing these are strongly pair-breaking. This fact is in rather strong contradiction with many experiments on disordered high-T_{c} superconductors assuming the d-wave nature of pairing in these systems. With the growth of electron attraction within the Cooper pair the system smoothly crosses over from BCS-pairs to compact Boson picture of superconductivity. As pairing strength grows and pairs become compact significant deviations from universal Abrikosov-Gorkov dependence of T_{c} on disorder appear in case of d-wave pairing with superconducting state becoming more stable than in the weak coupling case. As high-T_{c} superconductors are actually in the intermediate region with Cooper pairs size of the order of few interatomic lengths, these results can explain the relative stability of d-wave pairing under rather strong disordering.Comment: 8 pages, 3 figures, RevTeX 3.0, 1 Postscript figure attached, submitted to JETP Letter

Exchange Instabilities in Semiconductor Double Quantum Well Systems

We consider various exchange-driven electronic instabilities in semiconductor double-layer systems in the absence of any external magnetic field. We establish that there is no exchange-driven bilayer to monolayer charge transfer instability in the double-layer systems. We show that, within the unrestricted Hartree-Fock approximation, the low density stable phase (even in the absence of any interlayer tunneling) is a quantum ``pseudospin rotated'' spontaneous interlayer phase coherent spin-polarized symmetric state rather than the classical Ising-like charge-transfer phase. The U(1) symmetry of the double quantum well system is broken spontaneously at this low density quantum phase transition, and the layer density develops quantum fluctuations even in the absence of any interlayer tunneling. The phase diagram for the double quantum well system is calculated in the carrier density--layer separation space, and the possibility of experimentally observing various quantum phases is discussed. The situation in the presence of an external electric field is investigated in some detail using the spin-polarized-local-density-approximation-based self-consistent technique and good agreement with existing experimental results is obtained.Comment: 24 pages, figures included. Also available at http://www-cmg.physics.umd.edu/~lzheng/preprint/ct.uu/ . Revised final version to appear in PR

Pseudogap in the microwave response of YBa_2Cu_3O_{7-x}

The in-plane and out-of-plane surface impedance and microwave conductivity components of one and the same YBa_2Cu_3O_{7-x} (0.07\le x\le 0.47) single crystal are determined in the wide ranges of temperature T and carrier concentration p in CuO_2 planes. The following features of the superfluid density n_s(T,p)\propto\lambda_{ab}^{-2}(T,p) are observed at T<Tc/2 and 0.078\le p\le 0.16: (i) n_s(0,p) depends linearly on p, (ii) the derivative |dn_s(T,p)/dT|_{T\to 0} depends on p slightly in the optimally and moderately doped regions (0.10<p\le 0.16); however, it rapidly increases with p further lowering and (iii) the latter finding is accompanied by the linear low-temperature dependence \Delta n_s(T)\propto(-T) changing to \Delta n_s(T)\propto(-\sqrt{T}). For optimum oxygen content the temperature dependence of the normalized imaginary part of the c-axis conductivity \lambda_c^2(0)/\lambda_c^2(T) is found to be strikingly similar to that of \lambda_{ab}^2(0)/\lambda_{ab}^2(T) and becomes more convex with p lowering. \lambda_c^{-2}(0,p) values are roughly proportional to the normal state conductivities \sigma_c(T_c,p) along the c-axis. All these properties can be treated in the framework of d-density wave order of pseudogap.Comment: 7 pages, 9 figures, presented at EUCAS 2003 (September 14-18), submitted to SUS

A multi-analytical approach to gold in Ancient Egypt: studies on provenance and corrosion

Recent results from a three-year multi-disciplinary project on Ancient Egyptian gold jewellery revealed that items of jewellery from the Middle Kingdom to the New Kingdom were manufactured using a variety of alluvial gold alloys. These alloys cover a wide range of colours and the majority contain Platinum Group Elements inclusions. However, in all the gold foils analysed, these inclusions were found to be absent. In this work a selection of gilded wood and leather items and gold foil fragments, all from the excavations by John Garstang at Abydos (primarily from Middle Kingdom graves), were examined using Scanning Electron Microscopy-Energy Disperse Spectroscopy (SEM-EDS), X-Ray Fluorescence (µXRF), Particle Induced X-Ray Emission (µPIXE) and Double Dispersive X-Ray Fluorescence (D2XRF). The work allowed us to characterise the composition of the base-alloys and also to reveal the presence of Pt at trace levels, confirming the use of alluvial gold deposits. Corrosion products were also investigated in the foils where surface tarnish was visually observed. Results showed that the differences in the colour of corrosion observed for the foils are related not only to the thickness of the corrosion layer but also to a multi-layer structure containing the various corrosion products

The Notch pathway controls fibrotic and regenerative repair in the adult heart.

AIMS: In the adult heart, Notch signalling regulates the response to injury. Notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. The role of Notch in the mesenchymal stromal cell fraction, which contains cardiac fibroblasts and cardiac precursor cells, is, however, largely unknown. In the present study, we evaluate, therefore, whether forced activation of the Notch pathway in mesenchymal stromal cells regulates pathological cardiac remodelling. METHODS AND RESULTS: We generated transgenic mice overexpressing the Notch ligand Jagged1 on the surface of cardiomyocytes to activate Notch signalling in adjacent myocyte and non-myocyte cells. In neonatal transgenic mice, activated Notch sustained cardiac precursor and myocyte proliferation after birth, and led to increased numbers of cardiac myocytes in adult mice. In the adult heart under pressure overload, Notch inhibited the development of cardiomyocyte hypertrophy and transforming growth factor-β/connective tissue growth factor-mediated cardiac fibrosis. Most importantly, Notch activation in the stressed adult heart reduced the proliferation of myofibroblasts and stimulated the expansion of stem cell antigen-1-positive cells, and in particular of Nkx2.5-positive cardiac precursor cells. CONCLUSIONS: We conclude that Notch is pivotal in the healing process of the injured heart. Specifically, Notch regulates key cellular mechanisms in the mesenchymal stromal cell population, and thereby controls the balance between fibrotic and regenerative repair in the adult heart. Altogether, these findings indicate that Notch represents a unique therapeutic target for inducing regeneration in the adult heart via mobilization of cardiac precursor cells