Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.

We studied asbestos, vitreous fiber (MMVF10), and refractory ceramic fiber (RCF1) from the Thermal Insulation Manufacturers' Association fiber repository regarding the following: free radical damage to plasmid DNA, iron release, ability to deplete glutathione (GSH), and activate redox-sensitive transcription factors in macrophages. Asbestos had much more free radical activity than any of the man-made vitreous fibers. More Fe3+ was released than Fe2+ and more of both was released at pH 4.5 than at pH 7.2. Release of iron from the different fibers was generally not a good correlate of ability to cause free radical injury to the plasmid DNA. All fiber types caused some degree of oxidative stress, as revealed by depletion of intracellular GSH. Amosite asbestos upregulated nuclear binding of activator protein 1 transcription factor to a greater level than MMVF10 and RCF1; long-fiber amosite was the only fiber to enhance activation of the transcription factor nuclear factor kappa B (NF kappa B). The use of cysteine methyl ester and buthionine sulfoximine to modulate GSH suggested that GSH homeostasis was important in leading to activation of transcription factors. We conclude that the intrinsic free radical activity is the major determinant of transcription factor activation and therefore gene expression in alveolar macrophages. Although this was not related to iron release or ability to deplete macrophage GSH at 4 hr, GSH does play a role in activation of NF kappa B

SKA studies of nearby galaxies : star-formation, accretion processes and molecular gas across all environments

Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike LicenceThe SKA will be a transformational instrument in the study of our local Universe. In particular, by virtue of its high sensitivity (both to point sources and diffuse low surface brightness emission), angular resolution and the frequency ranges covered, the SKA will undertake a very wide range of astrophysical research in the field of nearby galaxies. By surveying vast numbers of nearby galaxies of all types with $\mu$Jy sensitivity and sub-arcsecond angular resolutions at radio wavelengths, the SKA will provide the cornerstone of our understanding of star-formation and accretion activity in the local Universe. In this chapter we outline the key continuum and molecular line science areas where the SKA, both during phase-1 and when it becomes the full SKA, will have a significant scientific impact.Peer reviewedFinal Published versio

VLBI observations of SN 2008iz: I. Expansion velocity and limits on anisotropic expansion

We present observations of the recently discovered supernova 2008iz in M82 with the VLBI High Sensitivity Array at 22 GHz, the Very Large Array at frequencies of 1.4, 4.8, 8.4, 22 and 43 GHz, and the Chandra X-ray observatory. The supernova was clearly detected on two VLBI images, separated by 11 months. The source shows a ring-like morphology and expands with a velocity of ~23000 km/s. The most likely explosion date is in mid February 2008. The measured expansion speed is a factor of ~2 higher than expected under the assumption that synchrotron self-absorption dominates the light curve at the peak, indicating that this absorption mechanism may not be important for the radio emission. We find no evidence for an asymmetric explosion. The VLA spectrum shows a broken power law, indicating that the source was still optically thick at 1.4 GHz in April 2009. Finally, we report upper limits on the X-ray emission from SN 2008iz and a second radio transient recently discovered by MERLIN observations.Comment: accepted Astronomy & Astrophysics, 9 pages, 8 figures, also available at http://www.mpifr-bonn.mpg.de/staff/abrunthaler/pub.shtm

AMI-LA Observations of the SuperCLASS Super-cluster

We present a deep survey of the SuperCLASS super-cluster - a region of sky known to contain five Abell clusters at redshift $z\sim0.2$ - performed using the Arcminute Microkelvin Imager (AMI) Large Array (LA) at 15.5$~$GHz. Our survey covers an area of approximately 0.9 square degrees. We achieve a nominal sensitivity of $32.0~\mu$Jy beam$^{-1}$ toward the field centre, finding 80 sources above a $5\sigma$ threshold. We derive the radio colour-colour distribution for sources common to three surveys that cover the field and identify three sources with strongly curved spectra - a high-frequency-peaked source and two GHz-peaked-spectrum sources. The differential source count (i) agrees well with previous deep radio source count, (ii) exhibits no evidence of an emerging population of star-forming galaxies, down to a limit of 0.24$~$mJy, and (iii) disagrees with some models of the 15$~$GHz source population. However, our source count is in agreement with recent work that provides an analytical correction to the source count from the SKADS Simulated Sky, supporting the suggestion that this discrepancy is caused by an abundance of flat-spectrum galaxy cores as-yet not included in source population models.Comment: 17 pages, 14 figures, 3 tables. Accepted for publication in MNRA

Carbonaceous aerosols contributed by traffic and solid fuel burning at a polluted rural site in Northwestern England

The experiment presented in this paper was conducted at the Holme Moss site, which is located in the southern Pennines region in Northwestern England during November–December 2006. The strong southwesterly wind during the experimental period, which enhanced the transport of urban pollutants from the conurbations of Greater Manchester and Liverpool, in addition to the seasonally increased nearby residential heating activities, made this site a receptor for pollutants from a range of sources. A factor analysis is applied to the mass spectra of organic matter (OM) measured by the Aerodyne Aerosol Mass Spectrometer (AMS) to attribute the pollutant sources. Besides the oxygenated organic aerosol (OOA), this site was found to contain a considerable fraction of primary organic aerosols (POA, mass fraction 50–70% within total mass of OM). The POA sources are attributed to be traffic emission and solid fuel burning, which are identified as hydrocarbon-like organic aerosol (HOA) and solid fuel organic aerosol (SFOA) respectively. There were strongly combined emissions of black carbon (BC) particles from both sources. The refractory BC component (rBC) was characterized by a single particle soot photometer. This site began to be influenced during the late morning by fresh traffic emissions, whereas solid fuel burning became dominant from late afternoon until night. A covariance analysis of rBC and POA was used to derive source specific emission factors of 1.61 μgHOA/μgrBC and 1.96 μgHOA/μgrBC. The absorbing properties of aerosols were characterized at multiple wavelengths (λ), and a stronger spectral dependence of absorption was observed when this site was significantly influenced by solid fuel burning. The rBC was estimated to contribute 3–16% of submicron aerosol mass. The single scattering albedo at λ = 700 nm (SSA<sub>700 nm</sub>) was significantly anti-correlated with the rBC mass fraction, but also associated with the BC mixing state. The BC incorporation/removal process therefore may play a role in modulating the radiative properties of aerosols at the site under the influence of fresh sources. Given that traffic and residential combustion of solid fuels are significant contributors of carbonaceous aerosols over Europe, these results provide important source-specific information on modeling the anthropogenic carbonaceous aerosols

Proton Zemach radius from measurements of the hyperfine splitting of hydrogen and muonic hydrogen

While measurements of the hyperfine structure of hydrogen-like atoms are traditionally regarded as test of bound-state QED, we assume that theoretical QED predictions are accurate and discuss the information about the electromagnetic structure of protons that could be extracted from the experimental values of the ground state hyperfine splitting in hydrogen and muonic hydrogen. Using recent theoretical results on the proton polarizability effects and the experimental hydrogen hyperfine splitting we obtain for the Zemach radius of the proton the value 1.040(16) fm. We compare it to the various theoretical estimates the uncertainty of which is shown to be larger that 0.016 fm. This point of view gives quite convincing arguments in support of projects to measure the hyperfine splitting of muonic hydrogen.Comment: Submitted to Phys. Rev.

LeMMINGs. VI. Connecting nuclear activity to bulge properties of active and inactive galaxies: radio scaling relations and galaxy environment

Multiwavelength studies indicate that nuclear activity and bulge properties are closely related, but the details remain unclear. To study this further, we combine $Hubble~Space~Telescope$ bulge structural and photometric properties with 1.5 GHz, $e$-MERLIN nuclear radio continuum data from the LeMMINGs survey for a large sample of 173 `active' galaxies (LINERs and Seyferts) and `inactive' galaxies (H IIs and absorption line galaxies, ALGs). Dividing our sample into active and inactive, they define distinct (radio core luminosity)$-$(bulge mass), L_R,core-M_*,bulge, relations, with a mass turnover at M_*, bulge ~ 10^(9.8 +- 0.3) M_sun (supermassive black hole mass M_BH ~ 10^(6.8 +- 0.3) M_sun), which marks the transition from AGN-dominated nuclear radio emission in more massive bulges to that mainly driven by stellar processes in low-mass bulges. None of our 10/173 bulgeless galaxies host an AGN. The AGN fraction increases with increasing M_*, bulge such that f_optical_AGN $\propto$ M_*,bulge^(0.24 +- 0.06) and f_radio_AGN $\propto$ M_*,bulge^(0.24 +- 0.05). Between M_*,bulge ~ 10^8.5 and 10^11.3 M_sun, f_optical_AGN steadily rises from 15 +- 4 to 80 +- 5 per cent. We find that at fixed bulge mass, the radio loudness, nuclear radio activity and the (optical and radio) AGN fraction exhibit no dependence on environment. Radio-loud hosts preferentially possess an early-type morphology than radio-quiet hosts, the two types are however indistinguishable in terms of bulge S\'ersic index and ellipticity, while results on the bulge inner logarithmic profile slope are inconclusive. We finally discuss the importance of bulge mass in determining the AGN triggering processes, including potential implications for the nuclear radio emission in nearby galaxies.Comment: 27 pages, 15 figures, 4 tables, accepted for publication in MNRA

Probing the accelerating Universe with radio weak lensing in the JVLA Sky Survey

We outline the prospects for performing pioneering radio weak gravitational lensing analyses using observations from a potential forthcoming JVLA Sky Survey program. A large-scale survey with the JVLA can offer interesting and unique opportunities for performing weak lensing studies in the radio band, a field which has until now been the preserve of optical telescopes. In particular, the JVLA has the capacity for large, deep radio surveys with relatively high angular resolution, which are the key characteristics required for a successful weak lensing study. We highlight the potential advantages and unique aspects of performing weak lensing in the radio band. In particular, the inclusion of continuum polarisation information can greatly reduce noise in weak lensing reconstructions and can also remove the effects of intrinsic galaxy alignments, the key astrophysical systematic effect that limits weak lensing at all wavelengths. We identify a VLASS "deep fields" program (total area ~10-20 square degs), to be conducted at L-band and with high-resolution (A-array configuration), as the optimal survey strategy from the point of view of weak lensing science. Such a survey will build on the unique strengths of the JVLA and will remain unsurpassed in terms of its combination of resolution and sensitivity until the advent of the Square Kilometre Array. We identify the best fields on the JVLA-accessible sky from the point of view of overlapping with existing deep optical and near infra-red data which will provide crucial redshift information and facilitate a host of additional compelling multi-wavelength science.Comment: Submitted in response to NRAO's recent call for community white papers on the VLA Sky Survey (VLASS

What is the progenitor of the Type Ia SN 2014J?

We report the deepest radio interferometric observations of the closest Type Ia supernova in decades, SN 2014J, which exploded in the nearby galaxy M 82. These observations represent, together with radio observations of SNe 2011fe, the most sensitive radio studies of a Type Ia SN ever. We constrain the mass-loss rate from the progenitor system of SN 2014J lower than 7.0 × 10^(−10) M yr^(−1) (for a wind speed of 100 km s^(−1) ). Our deep upper limits favor a double-degenerate scenario–involving two WD stars–for the progenitor system of SN 2014J, as such systems have less circumstellar gas than our upper limits. By contrast, most single-degenerate scenarios, i.e., the wide family of progenitor systems where a red giant, main-sequence, or sub-giant star donates mass to a exploding white dwarf, are ruled out by our observations. The evidence from SNe 2011fe and 2014J points in the direction of a double-degenerate scenario for both