Processing of targets in smooth or apparent motion along the vertical in the human brain: an fMRI study

Neural substrates for processing constant speed visual motion have been extensively studied. Less is known about the brain activity patterns when the target speed changes continuously, for instance under the influence of gravity. Using functional MRI (fMRI), here we compared brain responses to accelerating/decelerating targets with the responses to constant speed targets. The target could move along the vertical under gravity (1g), under reversed gravity (-1g), or at constant speed (0g). In the first experiment, subjects observed targets moving in smooth motion and responded to a GO signal delivered at a random time after target arrival. As expected, we found that the timing of the motor responses did not depend significantly on the specific motion law. Therefore brain activity in the contrast between different motion laws was not related to motor timing responses. Average BOLD signals were significantly greater for 1g targets than either 0g or -1g targets in a distributed network including bilateral insulae, left lingual gyrus, and brain stem. Moreover, in these regions, the mean activity decreased monotonically from 1g to 0g and to -1g. In the second experiment, subjects intercepted 1g, 0g, and -1g targets either in smooth motion (RM) or in long-range apparent motion (LAM). We found that the sites in the right insula and left lingual gyrus, which were selectively engaged by 1g targets in the first experiment, were also significantly more active during 1g trials than during -1g trials both in RM and LAM. The activity in 0g trials was again intermediate between that in 1g trials and that in -1g trials. Therefore in these regions the global activity modulation with the law of vertical motion appears to hold for both RM and LAM. Instead, a region in the inferior parietal lobule showed a preference for visual gravitational motion only in LAM but not RM

Obscuration in AGNs: near-infrared luminosity relations and dust colors

We combine two approaches to isolate the AGN luminosity at near-infrared wavelengths and relate the near-IR pure AGN luminosity to other tracers of the AGN. Using integral-field spectroscopic data of an archival sample of 51 local AGNs, we estimate the fraction of non-stellar light by comparing the nuclear equivalent width of the stellar 2.3 micron CO absorption feature with the intrinsic value for each galaxy. We compare this fraction to that derived from a spectral decomposition of the integrated light in the central arc second and find them to be consistent with each other. Using our estimates of the near-IR AGN light, we find a strong correlation with presumably isotropic AGN tracers. We show that a significant offset exists between type 1 and type 2 sources in the sense that type 1 sources are 7 (10) times brighter in the near-IR at log L_MIR = 42.5 (log L_X = 42.5). These offsets only becomes clear when treating infrared type 1 sources as type 1 AGNs. All AGNs have very red near-to-mid-IR dust colors. This, as well as the range of observed near-IR temperatures, can be explained with a simple model with only two free parameters: the obscuration to the hot dust and the ratio between the warm and hot dust areas. We find obscurations of A_V (hot) = 5 - 15 mag for infrared type 1 sources and A_V (hot) = 15 - 35 mag for type 2 sources. The ratio of hot dust to warm dust areas of about 1000 is nicely consistent with the ratio of radii of the respective regions as found by infrared interferometry.Comment: 17 pages, 10 Figures, 3 Tables, accepted by A&

Glassy states in lattice models with many coexisting crystalline phases

We study the emergence of glassy states after a sudden cooling in lattice models with short range interactions and without any a priori quenched disorder. The glassy state emerges whenever the equilibrium model possesses a sufficient number of coexisting crystalline phases at low temperatures, provided the thermodynamic limit be taken before the infinite time limit. This result is obtained through simulations of the time relaxation of the standard Potts model and some exclusion models equipped with a local stochastic dynamics on a square lattice.Comment: 12 pages, 4 figure

On the relation of optical obscuration and X-ray absorption in Seyfert galaxies

The optical classification of a Seyfert galaxy and whether it is considered X-ray absorbed are often used interchangeably. But there are many borderline cases and also numerous examples where the optical and X-ray classifications appear to be in conflict. In this article we re-visit the relation between optical obscuration and X-ray absorption in AGNs. We make use of our "dust color" method (Burtscher et al. 2015) to derive the optical obscuration A_V and consistently estimated X-ray absorbing columns using 0.3--150 keV spectral energy distributions. We also take into account the variable nature of the neutral gas column N_H and derive the Seyfert sub-classes of all our objects in a consistent way. We show in a sample of 25 local, hard-X-ray detected Seyfert galaxies (log L_X / (erg/s) ~ 41.5 - 43.5) that there can actually be a good agreement between optical and X-ray classification. If Seyfert types 1.8 and 1.9 are considered unobscured, the threshold between X-ray unabsorbed and absorbed should be chosen at a column N_H = 10^22.3 / cm^2 to be consistent with the optical classification. We find that N_H is related to A_V and that the N_H/A_V ratio is approximately Galactic or higher in all sources, as indicated previously. But in several objects we also see that deviations from the Galactic ratio are only due to a variable X-ray column, showing that (1) deviations from the Galactic N_H/A_V can simply be explained by dust-free neutral gas within the broad line region in some sources, that (2) the dust properties in AGNs can be similar to Galactic dust and that (3) the dust color method is a robust way to estimate the optical extinction towards the sublimation radius in all but the most obscured AGNs.Comment: 7 pages, 3 figures, accepted for publication by A&A; updated PDF to include abstrac

Electron-ion recombination of Si IV forming Si III: Storage-ring measurement and multiconfiguration Dirac-Fock calculations

The electron-ion recombination rate coefficient for Si IV forming Si III was measured at the heavy-ion storage-ring TSR. The experimental electron-ion collision energy range of 0-186 eV encompassed the 2p(6) nl n'l' dielectronic recombination (DR) resonances associated with 3s to nl core excitations, 2s 2p(6) 3s nl n'l' resonances associated with 2s to nl (n=3,4) core excitations, and 2p(5) 3s nl n'l' resonances associated with 2p to nl (n=3,...,infinity) core excitations. The experimental DR results are compared with theoretical calculations using the multiconfiguration Dirac-Fock (MCDF) method for DR via the 3s to 3p n'l' and 3s to 3d n'l' (both n'=3,...,6) and 2p(5) 3s 3l n'l' (n'=3,4) capture channels. Finally, the experimental and theoretical plasma DR rate coefficients for Si IV forming Si III are derived and compared with previously available results.Comment: 13 pages, 9 figures, 3 tables. Accepted for publication in Physical Review

Evolutionary Constraint Helps Unmask a Splicing Regulatory Region in BRCA1 Exon 11

BACKGROUND: Alternative splicing across exon 11 produces several BRCA1 isoforms. Their proportion varies during the cell cycle, between tissues and in cancer suggesting functional importance of BRCA1 splicing regulation around this exon. Although the regulatory elements driving exon 11 splicing have never been identified, a selective constraint against synonymous substitutions (silent nucleotide variations that do not alter the amino acid residue sequence) in a critical region of BRCA1 exon 11 has been reported to be associated with the necessity to maintain regulatory sequences. METHODOLOGY/PRINCIPAL FINDINGS: Here we have designed a specific minigene to investigate the possibility that this bias in synonymous codon usage reflects the need to preserve the BRCA1 alternative splicing program. We report that in-frame deletions and translationally silent nucleotide substitutions in the critical region affect splicing regulation of BRCA1 exon 11. CONCLUSIONS/SIGNIFICANCE: Using a hybrid minigene approach, we have experimentally validated the hypothesis that the need to maintain correct alternative splicing is a selective pressure against translationally silent sequence variations in the critical region of BRCA1 exon 11. Identification of the trans-acting factors involved in regulating exon 11 alternative splicing will be important in understanding BRCA1-associated tumorigenesis

Population of ground and lowest excited states of Sulfur via the dissociative recombination of SH+ in the diffuse interstellar medium

Our previous study on dissociative recombination of ground state SH$^+$ into $^2\Pi$ states of SH is extended by taking into account the contribution of $^4\Pi$ states recently explored by quantum chemistry methods. Multichannel quantum defect theory is employed for the computation of cross sections and rate coefficients for dissociative recombination, but also for vibrational excitation. Furthermore, we produce the atomic yields resulting from recombination, quantifying the generation of sulfur atoms in their ground (\mbox{$^3$P}) and lowest excited (\mbox{$^1$D}) states respectively.Comment: 9 pages, 8 figures, 3 table

Assessment van Kinderen en jongeren: noodzaak om de blik te verruimen

Het onderwijs wordt geconfrnteerd met het dilemma om deprstaties en rendement van leerlingen te verhogen en anderzids ook iets te doen voor een groelend aantal uitvallers of onderpresteerders. Het Daffodil.project is een Europees Comenius- project is een Europees Comenius_multilateral samenwerkingsproject met partners uit 7 landen (Belgie, Hongarije, Zweden,Portugal, Noorwegen, Roemenie en de Britse Maagdeneilanden)met als doel een model te ontwikkelen dat bruikbaar is om het functioneren van kinderen met een probleem beter in kaart te brege

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we report the mechanistic and biological characterisation of optimised N5-substituted paullone analogues with anti-TryS activity. Several of the new derivatives retained submicromolar IC50 against leishmanial TryS. The binding mode to TryS of the most potent paullones has been revealed by means of kinetic, biophysical and molecular modelling approaches. A subset of analogues showed an improved potency (EC50 0.5-10 µM) and selectivity (20-35) against the clinically relevant stage of Leishmania braziliensis (mucocutaneous leishmaniasis) and L. infantum (visceral leishmaniasis). For a selected derivative, the mode of action involved intracellular depletion of trypanothione. Our findings shed light on the molecular interaction of TryS with rationally designed inhibitors and disclose a new set of compounds with on-target activity against different Leishmania species