120 research outputs found

    Apparent Alkyl Transfer and Phenazine Formation via an Aryne Intermediate

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    Treatment of chlorotriaryl derivatives 3a and 3d or fluorotriaryl derivatives 3b and 3e with potassium diisopropylamide afforded alkyl-shifted phenazine derivatives 5a/5b, rather than the expected 9-membered triazaorthocyclophane 2a. The phenazine derivatives were isolated in 78–98% yield depending on the halogen and alkyl group present. In the absence of the halogen (chloro or fluoro), the apparent alkyl shift proceeds more slowly and cannot proceed via the intermediacy of the aryne intermediate. Mechanistic possibilities include intramolecular nucleophilic attack on an aryne intermediate leading to a zwitterionic intermediate and alkyl transfer via a 5-endo-tet process, or via a Smiles rearrangement

    A weekly regimen of cisplatin, paclitaxel and topotecan with granulocyte-colony stimulating factor support for patients with extensive disease small cell lung cancer: a phase II study

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    The present study was aimed at defining the antitumour activity of the cisplatin-paclitaxel-topotecan (CPT) weekly administration with G-CSF support in chemo-naive SCLC patients with extensive disease (ED-SCLC). Chemonaive ED-SCLC patients received cisplatin 40 mg/m2, paclitaxel 85 mg/m2, and topotecan 2.25 mg/m2weekly, with G-CSF (5 μg/kg days 3–5) support, for a maximum of 12 weeks. 37 patients were treated, for a total of 348 cycles delivered. 8 complete responses (22%) and 22 partial responses (59%) were recorded, giving an 81% [95% CI = 65–92%] ORR. At a 13-month (range, 4–26) median follow-up, median progression-free and overall survival were 8 months and 12.5 months, with 1-year and 2-year projected survivals of 55% and 21%, respectively. No toxic deaths occurred. Grade 4 neutropenia and thrombocytopenia occurred in 6 and 3 patients, respectively. Only one case of neutropenic sepsis was recorded, while haemorrhagic thrombocytopenia was never observed. Diarrhoea, paraesthesias and fatigue were the main nonhaematologic toxicities being severe in 6, 2 and 10 patients, respectively. The weekly CPT combination with G-CSF support represents a well tolerated therapeutic approach in chemo-naive ED-SCLC patients. The activity rate seems at least similar to that achievable with the standard front-line approaches. © 2001 Cancer Research Campaign http://www.bjcancer.co

    Erratum: Measurement of the t(t)over-bar production cross section in the dilepton channel in pp collisions at root s = 8 TeV (vol 2, 024, 2014)

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    LA CONSERVAZIONE PREVENTIVA E PROGRAMMATA. VENTI ANNI DOPO IL CODICE DEI BENI CULTURALI Bressanone (BZ), 2 - 5 luglio 2024

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    The research aims to delineate the role and centrality of the Registrar within the network of a cultural institution, thus contributing to its professional and social recognition, and introducing a new approach to investigating cultural professionals. Despite their crucial role in Heritage management and preservation, the Registrar lacks adequate acknowledgment and appreciation. This study adopts an interdisciplinary approach, integrating qualitative and quantitative codification of data to clarify the Registrar’s role and responsibilities in Italy and to re-establish the connection between the labor market and the national educational system. Through collaboration with national and international academic and professional institutions, as well as the analysis of skills and educational paths, the goal is to provide a comprehensive overview of the Registrar’s position in Italian cultural institutions

    A New Fingerprint Matching Algorithm Based on Minimum Cost Function

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