1,385 research outputs found
Nuclear structure study around Z=28
Yrast levels of Ni, Cu and Zn isotopes for have been
described by state-of-the-art shell model calculations with three recently
available interactions using Ni as a core in the model
space. The results are unsatisfactory viz. large for very neutron rich
nuclei, small B(E2) values in comparison to experimental values. These results
indicate an importance of inclusion of and orbitals
in the model space to reproduce collectivity in this region.Comment: 12 pages, 14 figure
Parametric Generation of Second Sound by First Sound in Superfluid Helium
We report the first experimental observation of parametric generation of
second sound (SS) by first sound (FS) in superfluid helium in a narrow
temperature range in the vicinity of . The temperature dependence
of the threshold FS amplitude is found to be in a good quantitative agreement
with the theory suggested long time ago and corrected for a finite geometry.
Strong amplitude fluctuations and two types of the SS spectra are observed
above the bifurcation. The latter effect is quantitatively explained by the
discreteness of the wave vector space and the strong temperature dependence of
the SS dissipation length.Comment: 4 pages, 4 postscript figures, REVTE
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Creating a Soluble Binder to Endothelin-1 Based on the Natural Ligand Binding Domains of the Endothelin-1 (G-Protein-Coupled) Receptor
Since its discovery in 1989, there has been extensive research on endothelin (ET)-1 physiology, as well as pathology. Accordingly,
there is considerable research on the discovery of therapeutics based around ET-1, amongst which current treatment
options include endothelin receptor antagonists. These target the ET-1 receptors, which are G-protein–coupled receptors
(GPCRs). We have effectively developed a soluble form of a GPCR that binds to ligands, by constructing a fusion polypeptide
of different endothelin receptor ligand binding domains. Phage experiments identified strong binders to ET-1. We then
constructed Fc-fusions of the top binders and further binding assays revealed a KD
of 21.2 nM for the Fc-ETtr1 construct
and KD
of 77.3 nM for the Fc-ETtr2 construct. These constructs are soluble and have the ability to bind and potentially
sequester elevated ET-1 levels that are prevalent in different diseases. These results provide a novel approach to targeting
GPCR–binding ligands, and thereby to contribute to a very important class of therapeutics
Low-Temperature Mobility of Surface Electrons and Ripplon-Phonon Interaction in Liquid Helium
The low-temperature dc mobility of the two-dimensional electron system
localized above the surface of superfluid helium is determined by the slowest
stage of the longitudinal momentum transfer to the bulk liquid, namely, by the
interaction of surface and volume excitations of liquid helium, which rapidly
decreases with temperature. Thus, the temperature dependence of the
low-frequency mobility is \mu_{dc} = 8.4x10^{-11}n_e T^{-20/3} cm^4 K^{20/3}/(V
s), where n_e is the surface electron density. The relation
T^{20/3}E_\perp^{-3} << 2x10^{-7} between the pressing electric field (in
kV/cm) and temperature (in K) and the value \omega < 10^8 T^5 K^{-5}s^{-1} of
the driving-field frequency have been obtained, at which the above effect can
be observed. In particular, E_\perp = 1 kV/cm corresponds to T < 70 mK and
\omega/2\pi < 30 Hz.Comment: 4 pages, 1 figur
Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).
We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09-4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services
Large scale shell model calculations for odd-odd Mn isotopes
Large scale shell model calculations have been carried out for odd-odd
Mn isotopes in two different model spaces. First set of calculations
have been carried out in full shell valence space with two recently
derived shell interactions namely GXPF1A and KB3G treating Ca
as core. The second set of calculations have been performed in
valence space with the interaction treating Ca as core and
imposing a truncation by allowing up to a total of six particle excitations
from the 0f orbital to the upper orbitals for protons and
from the upper orbitals to the 0g orbital for neutron. For
low-lying states in Mn, the KB3G and GXPF1A both predicts good results
and for Mn, KB3G is much better than GXPF1A. For negative parity and
high-spin positive parity states in both isotopes interaction is
required. Experimental data on Mn is sparse and therefore it is not
possible to make any definite conclusions. More experimental data on negative
parity states is needed to ascertain the importance of 0g and higher
orbitals in neutron rich Mn isotopes.Comment: 5 pages, 4 figures, Submitted to Eur. Phys. J.
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