Syringomatous carcinoma: Case report of a rare tumor entity

Syringomatous carcinoma is a rare cutaneous neoplasm, most frequently situated on the face and scalp and histologically characterised by aninfiltrative pattern of basaloid or squamous cells, a desmoplastic stromal reaction and keratin filled cysts. We report the case of a 76-year-oldwoman who presented an ulcerative interscapular lesion measuring 3x4cm. After resection, the histological examinations of the specimens haveidentified a basal cell carcinoma. However, a local recurrence was observed 18 months later; histopathological findings showed a syringomatouspattern and neoplastic epithelial cells arranged in interconnecting cords with microcystic areas. Nests, cords, and tubules of the tumour extendedinto the dermis and into the adjacent muscle. Sclerosis of stroma around the cords was present. Tumour cells were not connected to the epidermis. The immunohistochemical analysis showed positivity for anti-CK7, AE1/AE3 and negativity for anti CEA and anti CK20. These histological and immunohistochemical analyses were consistent with the diagnosis of syringomatous eccrine carcinoma. Syringomatous carcinoma is an extremely invasive tumor, locally destructive and slowly growing adnexal tumour, derived from eccrine sweat glands. It is often mistaken, both clinically and microscopically, for other benign and malignant entities. The tumour recurrence is high due to extensive perineural invasion, butregional or distant metastases are rare. The local aggressive nature of the tumour and the high recurrence rate may necessitate mutilating procedures. Optimal treatment consists of a complete microscopically controlled surgical excision with clear surgical margins. Key words: Syringomatous carcinoma, histopathology, immunohistochemistry, differential diagnosi

Transitional cell carcinoma of the ovary: A rare case and review of literature

<p>Abstract</p> <p>Introduction</p> <p>Transitional cell carcinoma (TCC) of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial cancer.</p> <p>Case presentation</p> <p>A 69-year-old postmenopausal woman presented with a 2-year history of progressive enlargement of an abdominal mass. Abdominal computed tomography showed a pelvic mass. CA-125 was normal. A staging operation with total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy and pelvic lymph node dissection was performed. After surgery, the pathologic report of the right ovarian tumour was TCC, grade 3, stage IC. The patient underwent 3 cycles of chemotherapy: carboplatin and paclitaxel. She is regularly followed up and has been disease free for 10 months</p> <p>Conclusion</p> <p>Transitional cell carcinoma (TCC) of the ovary is a rare subtype of epithelial ovarian cancer. Surgical resection is the primary therapeutic approach, and patient outcomes after chemotherapy are better than for other types of ovarian cancers.</p

Excellente réponse à la radiothérapie externe d’un synovialosarcome primitif de la glande parotide

Le synovialosarcome de la parotide est rare, peu de cas ont &eacute;t&eacute; rapport&eacute;s dans la litt&eacute;rature. Nous rapportons l&rsquo;observation d&rsquo;une patiente &acirc;g&eacute;e de 40 ans qui a pr&eacute;sent&eacute; d&rsquo;un synovialosarcome primitif de la parotide, dont le traitement a associ&eacute; une chirurgie suivie d&rsquo;une radioth&eacute;rapie adjuvante. L&rsquo;&eacute;volution a &eacute;t&eacute; marqu&eacute;e par un bon contr&ocirc;le locor&eacute;gional avec un recul de 6 ans. Le but de notre travail est de rapporter un excellent contr&ocirc;le locor&eacute;gional d&rsquo;un synovialosarcome primitif de la parotide par un traitement multimodal combinant l&rsquo;ex&eacute;r&egrave;se chirurgicale large &agrave; une radioth&eacute;rapie externe.Key words: Synovialosarcome, parotide, chirurgie, radioth&eacute;rapi

Lymphome malin non hodgkinien primitif bilatéral du sein: à propos d’un cas

Les lymphomes malins non-hodgkiniens (LMNH) primitifs du sein sont des tumeurs rares. Leur symptomatologie clinique est polymorphe. L'imagerie médicale est non-spécifique. Le diagnostic peut être évoqué à l'examen cytologique, sa confirmation est toujours histologique. Il s'agit essentiellement de lymphomes de type B, ceux de type NK/T restant rares. Les plus fréquents sont les lymphomes diffus à grandes cellules présentant la particularité de donner des rechutes sous forme d'extension au système nerveux central. Nous rapportons un cas de LMNH primitif bilatéral du sein chez une patiente âgée de 33 ans, révélé par deux nodules mammaires bilatéraux. La mammographie et l'examen extemporané ont évoqué une tumeur phyllode. Le diagnostic du LMNH n'a été fait qu'après examen histologique définitif. Sous chimiothérapie, l'évolution était favorable avec un recul de 15 mois

Expression of the Domain Cassette 8 <i>Plasmodium falciparum</i> Erythrocyte Membrane Protein 1 Is Associated with Cerebral Malaria in Benin

<div><p>Background</p><p><i>Plasmodium falciparum</i> erythrocyte membrane protein-1 (<i>Pf</i>EMP-1) is a highly polymorphic adherence receptor expressed on the surface of infected erythrocytes. Based on sequence homology <i>Pf</i>EMP-1 variants have been grouped into three major groups A-C, the highly conserved VAR2CSA variants, and semi-conserved types defined by tandem runs of specific domains (“domain cassettes” (DC)). The <i>Pf</i>EMP-1 type expressed determines the adherence phenotype, and is associated with clinical outcome of infection.</p><p>Methods</p><p>Parasite isolates from Beninese children or women presenting with, respectively, CM or PAM were collected along with samples from patients with uncomplicated malaria (UM). We assessed the transcript level of <i>var</i> genes by RT-qPCR and the expression of PfEMP-1 proteins by LC-MS/MS.</p><p>Results</p><p><i>Var</i> genes encoding DC8 and Group A <i>Pf</i>EMP-1 were transcribed more often and at higher levels in cerebral malaria <i>vs.</i> uncomplicated malaria patients. LC-MS/MS identified peptides from group A, DC8 <i>Pf</i>EMP-1 more frequently in cerebral malaria than in uncomplicated malaria and pregnancy-associated malaria samples.</p><p>Conclusion</p><p>This is the first study to show association between <i>Pf</i>EMP-1 subtype and disease outcome by direct analysis of parasites proteome. The results corroborate that group A and specifically the <i>Pf</i>EMP-1 types DC8 are universally associated with cerebral malaria. This is a crucial observation for promoting studies on malaria pathogenesis.</p></div