45 research outputs found
Omega-3 polyunsaturated fatty acids in the prevention of postoperative atrial fibrillation in open heart surgery: a systematic review and meta-analysis
Aim. To evaluate the literature data on the efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in the prevention of postoperative atrial fibrillation (POAF) in elective cardiac surgery, including onor off-pump coronary artery bypass grafting and/or valve replacement and/or repair.Material and methods. The search for studies was carried out using the PubMed database and Google Scholar from 2005 to January 31, 2022. From the initially identified search results, 19 articles were analyzed. The design of articles corresponded to randomized clinical trials. Omega-3 PUFAs was selected as an interventional effect. The studies were to include, as an end point, the assessment of new POAF cases in the early period after open heart surgery.Results. The meta-analysis included 15 studies with 3980 patients, of which 1992 (50,0%) patients took omega-3 PUFAs. POAF occurred in 587 (29,5%) patients receiving omega-3 PUFAs and 679 (34,2%) patients on standard therapy (hazard ratio, 0,8, 0,68-0,93, p=0,004). There is a variation in effect size for POAF patients in the presented randomized clinical trials relative to the axis of the central trend and heterogeneity of studies with a significant number of patients included (I2=51%, p=0,01).Conclusion. Our systematic review and meta-analysis showed the effectiveness of omega-3 PUFAs in the prevention of POAF during open heart surgery
ΠΠ°ΡΡΠ°Π½ΠΎΠΈΠ΄Π½Π°Ρ Π²Π½Π΅ΡΠ½ΠΎΡΡ Ρ ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡ ΡΠΈΡΠΊΠ° ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎ Π² Ρ ΠΎ ΡΡΠ΅ΠΎΠΏΠΎΡΠΎΠ·ΠΎΠΌ
Objective: to investigate the relationship between some signs of hereditary connective tissue disorders (HCTDs) as a Marfanoid appearanceΒ (MA) and the risk of atrial fibrillation (AF) in female patients with osteoporosis (OP).Subjects and methods. In 2014β2015, the investigation enrolled consecutively 104 women aged 58 to 70 years (mean age, 64.7Β±3.8 years)Β who had a verified diagnosis of primary OP and a body mass index of β€25.0 kg/m2. The entries in the outpatient medical records and in theΒ automated information system Β«PolyclinicΒ» were retrospectively analyzed to divide the patients into 2 groups according to the sign of the documentedΒ diagnosis of AF. A study group consisted of 53 women (mean age, 65.6Β±5.2 years) with AF and OP; a control group included 38 patientsΒ (mean age, 64.9Β±4.7 years) with OP without AF; a control group comprised 38 patients (mean age, 65.1Β±3.9 years) without OP and AF.Β Anthropometric and phenotypical parameters and cardiovascular visceral signs were analyzed; the levels of transforming growth factor-Ξ²1Β (TGFΞ²1) and interleukin (IL) 1Ξ² and 6 in the serum and those of deoxypyridinoline (DPD) in the urine were measured.Results. Analysis of the phenotypical signs of HCTDs in the patients with OP has shown that those with OP and AF have external signs of dysmorphogenesisΒ and meet the criteria of MA. Statistically significant correlations were found between the frequency of MA signs and the magnitudeΒ of all cardiac morphometric parameters and the visceral signs of HCTDs in the study group. The serum levels of IL-1Ξ², IL-6, and TGFΞ²1Β in these patients were significantly higher than in the comparison and control groups. There was also a high correlation between the signs of MAΒ and the content of DPD in the study group.Conclusion. The patients with OP and AF was found to have a statistically significant correlation of the phenotypical signs of dysmorphogenesisΒ with the frequency of visceral signs of HCTD, the morphofunctional parameters of the heart, and the high concentration of cytokines andΒ DPD. It may be suggested that there exists a genetically determined mechanism of connective tissue dysembryogenesis in OP, which is associatedΒ with the risk of AF.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Π½Π°ΡΠ»Π΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ (ΠΠΠ‘Π’) Π²Β Π²ΠΈΠ΄Π΅ ΠΌΠ°ΡΡΠ°Π½ΠΎΠΈΠ΄Π½ΠΎΠΉ Π²Π½Π΅ΡΠ½ΠΎΡΡΠΈ (ΠΠ) ΠΈ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠΈ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ (Π€Π) Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ ΠΎΡΡΠ΅ΠΎΠΏΠΎΡΠΎΠ·ΠΎΠΌ (ΠΠ).ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π 2014β2015 Π³Π³. Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 104 ΠΆΠ΅Π½ΡΠΈΠ½Ρ Ρ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΠ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 58 Π΄ΠΎ 70 Π»Π΅Ρ (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ β 64,7Β±3,8 Π³ΠΎΠ΄Π°) Ρ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° Π25,0 ΠΊΠ³/ΠΌ2. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π·Π°ΠΏΠΈΡΠ΅ΠΉ Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠ΅ Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ, Π° ΡΠ°ΠΊΠΆΠ΅ Π² Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅ Β«ΠΠΎΠ»ΠΈΠΊΠ»ΠΈΠ½ΠΈΠΊΠ°Β» Ρ ΡΠ΅Π»ΡΡ ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Π½Π° Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ ΠΏΠΎ ΠΏΡΠΈΠ·Π½Π°ΠΊΡ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π€Π. ΠΡΠ½ΠΎΠ²Π½ΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 53 ΠΆΠ΅Π½ΡΠΈΠ½Ρ Ρ Π€Π ΠΈ ΠΠ (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ β 65,6Β±5,2 Π³ΠΎΠ΄Π°); Π³ΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ β 51 ΠΆΠ΅Π½ΡΠΈΠ½Π° Ρ ΠΠ Π±Π΅Π· Π€ΠΒ (64,9Β±4,7 Π³ΠΎΠ΄Π°); Π³ΡΡΠΏΠΏΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ β 38 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Π±Π΅Π· ΠΠ ΠΈ Π€Π (65,1Β±3,9 Π³ΠΎΠ΄Π°). ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π°Π½ΡΡΠΎΠΏΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅, ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ, ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΠ΅ Π²ΠΈΡΡΠ΅ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΡΡΠ°Β Ξ²1 (TGFΞ²1), ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π° (ΠΠ) 1Ξ² ΠΈ 6 Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈ Π΄Π΅Π·ΠΎΠΊΡΠΈΠΏΠΈΡΠΈΠ΄ΠΈΠ½ΠΎΠ»ΠΈΠ½Π° (ΠΠΠΠ) Π² ΠΌΠΎΡΠ΅.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ½Π°Π»ΠΈΠ· ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΠΠ‘Π’ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠ ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΊΠΈ Ρ ΠΠ ΠΈ Π€Π ΠΈΠΌΠ΅ΡΡ Π²Π½Π΅ΡΠ½ΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ Π΄ΠΈΠ·ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΈ ΠΎΡΠ²Π΅ΡΠ°ΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ ΠΠ. ΠΡΡΠ²Π»Π΅Π½Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ°ΡΡΠΎΡΠΎΠΉ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΠ ΠΈ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡΡ Π²ΡΠ΅Ρ
ΠΌΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ΅ΡΠ΄ΡΠ° ΠΈ Π²ΠΈΡΡΠ΅ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ ΠΠΠ‘Π’ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ. Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΠ1Ξ², ΠΠ6, TGFΞ²1 Ρ ΡΡΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Π±ΡΠ»ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ Π»ΠΈΡ Π³ΡΡΠΏΠΏ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ. Π’Π°ΠΊΠΆΠ΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ ΠΠ ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ ΠΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ Ρ ΠΠ ΠΈ Π€Π Π²ΡΡΠ²Π»Π΅Π½Π° ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΡΠ΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² Π΄ΠΈΠ·ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΡΒ ΡΠ°ΡΡΠΎΡΠΎΠΉ Π²ΠΈΡΡΠ΅ΡΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΠΠ‘Π’, ΠΌΠΎΡΡΠΎΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠ΅ΡΠ΄ΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² ΠΈ ΠΠΠΠ. ΠΠΎΠΆΠ½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ ΠΏΡΠΈ ΠΠ ΠΈΠΌΠ΅Π΅ΡΡΡ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Π΄Π΅ΡΠ΅ΡΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌ Π΄ΠΈΠ·ΡΠΌΠ±ΡΠΈΠΎΠ³Π΅Π½Π΅Π·Π° ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΡΠΎΠΏΡΡΠΆΠ΅Π½Π½ΡΠΉ Ρ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π€Π
Creating and observing N-partite entanglement with atoms
The Mermin inequality provides a criterion for experimentally ruling out
local-realistic descriptions of multiparticle systems. A violation of this
inequality means that the particles must be entangled, but does not, in
general, indicate whether N-partite entanglement is present. For this, a
stricter bound is required. Here we discuss this bound and use it to propose
two different schemes for demonstrating N-partite entanglement with atoms. The
first scheme involves Bose-Einstein condensates trapped in an optical lattice
and the second uses Rydberg atoms in microwave cavities.Comment: 12 pages, 4 figure
Ionization of Rydberg atoms by blackbody radiation
We have studied an ionization of alkali-metal Rydberg atoms by blackbody
radiation (BBR). The results of the theoretical calculations of ionization
rates of Li, Na, K, Rb and Cs Rydberg atoms are presented. Calculations have
been performed for nS, nP and nD states which are commonly used in a variety of
experiments, at principal quantum numbers n=8-65 and at the three ambient
temperatures of 77, 300 and 600 K. A peculiarity of our calculations is that we
take into account the contributions of BBR-induced redistribution of population
between Rydberg states prior to photoionization and field ionization by
extraction electric field pulses. The obtained results show that these
phenomena affect both the magnitude of measured ionization rates and shapes of
their dependences on n. A Cooper minimum for BBR-induced transitions between
bound Rydberg states of Li has been found. The calculated ionization rates are
compared with our earlier measurements of BBR-induced ionization rates of Na nS
and nD Rydberg states with n=8-20 at 300 K. A good agreement for all states
except nS with n>15 is observed. Useful analytical formulas for quick
estimation of BBR ionization rates of Rydberg atoms are presented. Application
of BBR-induced ionization signal to measurements of collisional ionization
rates is demonstrated.Comment: 36 pages, 16 figures. Paper is revised following NJP referees'
comments and suggestion
ΠΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΊΠ°ΠΊ ΠΌΠ°ΡΠΊΠ΅ΡΡ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΏΡΠΈ ΠΎΡΡΡΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΡΠΎΠ½Π·ΠΈΠ»Π»ΠΈΡΠ°
Evaluation of nonspecific adaptive response of the body in children with acute infectious diseases associated with tonsillitis syndrome was the aim of this research. This prospective study included clinical, anamnestic and laboratory examination of children with acute infectious diseases with tonsillitis syndrome. A systemic multiple factor analysis was conducted (significance level Ρ<0.05). The evaluation of peripheral blood parameters (specific gravity of lymphocytes and indices of reactive protective potential (RPP) - specific immune lymphocytic-monocytic parameter (SILMP) and coefficient of phagocytic defense (CPD)) gives the possibility to determine the condition of nonspecific adaptation in children with acute infectious diseases associated with tonsillitis syndrome. Children with tonsillitis syndrome show significant increase of integral RPP parameters, i.e. decrease of RPP, which is more pronounced on discharge (on admission - in 57% of children, on discharge - in 87%). The most unfavourable initial nonspecific adaptative body response (NABR) (according to the percentage of lymphocytes) is the reaction of increased activation, as it is associated with the transition to the overactivation by the time of discharge (37% of children). Systemic multiple factor analysis determined which peripheral blood parameters have more influence on childrenβs adaptation during the course of infectious disease: RPP indices showed high influence coefficients in all diseases (CPD was the highest in bacterial infection - Π i 198.3; SILMP was the highest in viral infection - Π i 147.81; in mixed infection CPD and SILMP were roughly the same - Π i β 107.25 and Π i - 78.11, respectively), which proves the feasibility of RPP evaluation for prognostic purposes in the treatment of this category of patients.Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²ΠΈΠ»Π°ΡΡ ΠΎΡΠ΅Π½ΠΊΠ° Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΎΡΡΡΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΡΠΎΠ½Π·ΠΈΠ»Π»ΠΈΡΠ°. ΠΠ°Π½Π½ΠΎΠ΅ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ°Π»ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΎΡΡΡΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΡΠΎΠ½Π·ΠΈΠ»Π»ΠΈΡΠ°. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΠΉ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· (ΡΡΠΎΠ²Π΅Π½Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ Ρ<0,05). ΠΡΠ΅Π½ΠΊΠ° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ (ΡΠ΄Π΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π΅ΡΠ° Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎ-ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π» (Π ΠΠ) - ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°ΡΠ½ΠΎ-ΠΌΠΎΠ½ΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ° (ΠΠΠΠ) ΠΈ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠ° ΡΠ°Π³ΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠΉ Π·Π°ΡΠΈΡΡ (ΠΠ€Π) Π΄Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΈ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΎΡΡΡΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΡΠΎΠ½Π·ΠΈΠ»Π»ΠΈΡΠ°. Π£ Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ ΡΠΎΠ½Π·ΠΈΠ»Π»ΠΈΡΠ° ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π³ΡΠ°Π»ΡΠ½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π ΠΠ, Ρ. Π΅. ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π ΠΠ, ΠΊΠΎΡΠΎΡΠΎΠ΅ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½ΠΎ ΠΏΡΠΈ Π²ΡΠΏΠΈΡΠΊΠ΅ (ΠΏΡΠΈ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠΈ - Ρ 57% Π΄Π΅ΡΠ΅ΠΉ, ΠΏΡΠΈ Π²ΡΠΏΠΈΡΠΊΠ΅ - Ρ 87%). ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠΉ ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠΉ Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠ΅ΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° (ΠΏΠΎ ΠΏΡΠΎΡΠ΅Π½ΡΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ²) ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ, ΡΠ°ΠΊ ΠΊΠ°ΠΊ ΠΎΠ½Π° ΡΠ²ΡΠ·Π°Π½Π° Ρ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ΠΎΠΌ ΠΊ Π³ΠΈΠΏΠ΅ΡΠ°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΊ ΠΌΠΎΠΌΠ΅Π½ΡΡ Π²ΡΠΏΠΈΡΠΊΠΈ (37% Π΄Π΅ΡΠ΅ΠΉ). Π‘ΠΈΡΡΠ΅ΠΌΠ½ΡΠΉ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°ΠΊΡΠΎΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ», ΠΊΠ°ΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π±ΠΎΠ»ΡΡΠ΅Π΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° Π°Π΄Π°ΠΏΡΠ°ΡΠΈΡ Π΄Π΅ΡΠ΅ΠΉ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ: ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π ΠΠ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΡ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΏΡΠΈ Π²ΡΠ΅Ρ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΡ
, ΡΡΠΎ Π΄ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ Π ΠΠ Π² ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π»ΡΡ
ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Role of homocysteine metabolism in the development of endothelial dysfunction and hypertension in patients with multiple myeloma
The article is devoted to the modern understanding of endothelial dysfunction development, the role of hyperhomocysteinemia, and, as a consequence, hypertension in patients with multiple myeloma receiving multiagent chemotherapy. Considering that the potential of a standard examination does not allow identifying subclinical endothelial dysfunction, using specific techniques is necessary, in particular, to determine the homocysteine level to monitor the endothelial function.The aim of this review was to summarize the current understanding of hypertension etiology and prospects for detecting early, subclinical endothelial changes, including in patients with multiple myeloma.Assessment of endothelial dysfunction can be useful for detecting precisely the subclinical cardiovascular disease in order to stratify the risk of developing cardiovascular events in patients receiving multiagent chemotherapy
Genetic polymorphisms associated with the development of arrhythmic type of cardiovascular events
The review analyzes the global agenda on mutational status of genes associated with adverse cardiovascular events of arrhythmic type. Whole exome sequencing will identify a risk group for the likelihood of early or delayed cardiovascular events of arrhythmic type, especially among patients receiving anticancer therapy with cardiotoxic drugs. The dedicated up-to-date panel of genetic polymorphisms will provide an opportunity to optimize management of patients, based on not only clinical, paraclinical and anamnestic data
Omega-3 Polyunsaturated Fatty Acids: the Role in Prevention of Atrial Fibrillation in Patients with Coronary Artery Disease after Coronary Artery Bypass Graft Surgery
Aim. To estimate the role of omega-3 polyunsaturated fatty acids (PUFAs) administration in atrial fibrillation (AF) prevention after planned coronary artery bypass graft (CABG) surgery.Material and Methods. Studied were 306 patients divided into two groups: patients of group I didnβt receive PUFAs (158 patients, 82.7% males) and patients of group II received PUFAs (148 patients, 89.3% males). PUFAs were prescribed in daily dose 2000 mg 5 days before surgery and in daily dose 1000 mg in postoperative period during 21 days.Results. Postoperative AF (POAF) occurred in 29.7% patients in group I and in 16.9% patients in group II (Ρ=0.009). We found that after CABG in patients of the I group median IL-6 level was 39.3% higher (p=0.001), interleukin-10 β 20.2% higher (p=0.01), superoxide dismutase β 78.9% higher (Ρ<0.001), malondialdehyde β 33.8% higher (p=0.03), docosahexaenoic acid β 31.8% lower (p=0.01) and omega-3 index β 43.4%Β Β Β lower (p=0.04) than in patients of the II group.According to multivariate regression analysis we found significant association between the factors of inflammation, oxidative stress and the risk POAF development.Conclusions. In patients who took PUFAs, we found less activation of inflammation, oxidative stress, the increasing of docosahexaenoic acid and omega-3 index accompanied by the decreasing of POAF development rates up to 12.8%
The problem of the processes research of microcirculation blood rheology in the internal diseasesβ clinic
Π’he issues of studying the processes of microcirculalion and blood rtiecriogy in the clinic of internal diseases were studied. Modem data from researchers on the study of mtoocralatay and hemorheological disorders in patients with various pathologies of internal organs are presented. The mail regiianbes of regulatory mechanisms and methods of clinical and functional assessment of the microvasculature and theological properties of blood are reflected. Indicators of the state of the microvasculature and the theological properties of blood can serve as prognostic criteria not only in assessing the disease itself.but also in assessing the risk ofthrombotic and other complicalions in the cfeiic of internal diseases.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π²ΠΎΠΏΡΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΌΠΈΠΊΡΠΎΡΠΈΡΠΊΡΠ»ΡΡΠΈΠΈ ΠΈ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΡΠΎΠ²ΠΈ Π² ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΡΡΠ΄Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠΈΠΊΡΠΎΡΠΈΡΠΊΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΠΈ Π³Π΅ΠΌΠΎΡΠ΅ΠΎΠ»ΠΎΡΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠΌΠΈ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
ΠΎΡΠ³Π°Π½ΠΎΠ². ΠΡΡΠ°ΠΆΠ΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ²ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΌΠΈΠΊΡΠΎΡΠΈΡΠΊΡΠ»ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ»Π° ΠΈ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΊΡΠΎΠ²ΠΈ. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΌΠΈΠΊΡΠΎΡΠΈΡΠΊΡΠ»ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ»Π° ΠΈ ΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΊΡΠΎΠ²ΠΈ ΠΌΠΎΠ³ΡΡ ΡΠ»ΡΠΆΠΈΡΡ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌΠΈ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Π΄Π»Ρ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π½ΠΎ ΠΈ ΠΏΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΠΈΡΠΊΠΎΠ² ΠΊΠ°ΡΠ΄ΠΈΠΎ-Π²Π°ΡΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π² ΠΊΠ»ΠΈΠ½ΠΈΠΊΠ΅ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΡ
Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ