Чрескожная высокочастотная селективная ризотомия в терапии тригеминальной невралгии при рассеянном склерозе

Trigeminal neuralgia is a rare symptom of multiple sclerosis affecting the disability. Multiple sclerosis related trigeminal neuralgia has been attributed to a demyelinating lesion in the pons. When the adequate pain drug-relieve therapy is not possible or when the patient becomes refractory to the treatment or can not continue pharmacological treatment because of the side effects, surgical intervention, including percutaneous radiofrequency rhizotomy is being discussed. Literature review and the data upon the efficiency and safety of this neurosurgical treatment in 16 patients with multiple sclerosis have been analyzed. Percutaneous radiofrequency rhizotomy has been proved to be a safe, reproducible and effective method of the symptomatic surgical treatment of trigeminal neuralgia in patients with multiple sclerosis in cases of the intolerance/inefficiency of the pharmacological therapy.Невралгия тройничного нерва (НТН) является относительно редким, но инвалидизирующим симптомом при рассеянном склерозе (РС). В качестве наиболее частой причины считается наличие очага демиелинизации в варолиевом мосту. При ограничении возможностей медикаментозной терапии НТН при РС в связи побочными эффектами рассматривается возможность различных методов хирургического лечения, в том числе проведение чрескожной высокочастотной селективной ризотомии (ЧВСР). Приведены литературные и собственные данные оценки эффективности и безопасности ЧВСР при НТН у 16 больных РС. Полученные результаты позволили заключить, что ЧВСР является безопасным, повторяемым и эффективным методом симптоматического хирургического лечения НТН при РС при неэффективности/непереносимости медикаментозной терапии

Spatial structure, thermodynamics and kinetics of formation of hydrazones derived from pyridoxal 5′-phosphate and 2-furoic, thiophene-2-carboxylic hydrazides in solution

© 2019 Elsevier B.V. The spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazide in aqueous solution was studied by means of quantum chemical calculations and NOE experiment. The hydrazones could exist as a mixture of different conformers; however, the specific ones could be suggested from experimental and calculated data. The stability constants of hydrazones at pH of 1.9; 6.6; 7.0; 7.4 were determined using UV–Vis spectroscopy. Rate constants of the hydrazone formation and hydrolysis reaction within the range of 6.6–7.4 pH were obtained. Isothermal calorimetric titration was performed in order to determine the change in the free Gibbs energy, enthalpy and entropy of hydrazones formation at pH of 6.6. Hydrazones were synthesized and characterized by means of 1 H, 13 C, 31 P NMR, IR, UV–Vis, fluorescent, MS-spectroscopy as well as DSC and elemental analysis

Spatial structure, thermodynamics and kinetics of formation of hydrazones derived from pyridoxal 5′-phosphate and 2-furoic, thiophene-2-carboxylic hydrazides in solution

© 2019 Elsevier B.V. The spatial structure of pyridoxal 5′-phosphate hydrazones of 2-furoic hydrazide; thiophene-2-carboxylic hydrazide in aqueous solution was studied by means of quantum chemical calculations and NOE experiment. The hydrazones could exist as a mixture of different conformers; however, the specific ones could be suggested from experimental and calculated data. The stability constants of hydrazones at pH of 1.9; 6.6; 7.0; 7.4 were determined using UV–Vis spectroscopy. Rate constants of the hydrazone formation and hydrolysis reaction within the range of 6.6–7.4 pH were obtained. Isothermal calorimetric titration was performed in order to determine the change in the free Gibbs energy, enthalpy and entropy of hydrazones formation at pH of 6.6. Hydrazones were synthesized and characterized by means of 1 H, 13 C, 31 P NMR, IR, UV–Vis, fluorescent, MS-spectroscopy as well as DSC and elemental analysis