Students virtual and social identity in the process of humanities study: The problems of its correction

© 2016, Econjournals. All rights reserved.The relevance of the research problem is reasoned by global use of Internet technologies, altering the forms of personal self-identification: Atransition of the external world and human individuality in a digital code, the creation of informational imprint in space of the worldwide web, the alienation of the student youth in society, the substitution of reality by virtual world. In this direction a significant potential belongs to humanities, studying of which contributes to the interpenetration and mutual reinforcement of students’ social and virtual identification based on universal norms, values, value orientations, correction of virtual identity redundancy in real society. This article is aimed at scientifically-methodical substantiation of structure and content of pedagogical correction of higher school students’ self-identification in the process of humanities’ study. The leading method in this problem study is a method of modeling of the structure and content of students’ self-identification pedagogical correction in the process of humanitarian disciplines’ study. The article presents the theoretical and methodological foundations of the design and implementation of student’s social and virtual identity correction’s model, its discursive content and mechanisms, structure and new forms’ content in the process of humanities’ study. The presented materials in the article contribute to evidence-based correction of students virtual and social identity in the process of humanities’ study and are recommended to use for teachers, methodologists, university information departments’ programmers, improvement of qualification and teacher retraining courses’ attendants

Доклиническое токсикологическое изучение алофаниба — аллостерического ингибитора рецептора фактора роста фибробластов 2 типа

Background. Inhibition of fibroblast growth factor receptor type 2 (FGFR2) appears to be appropriate in patients with tumors expressing or amplifying FGFR2. The toxicity of allosteric FGFR2 inhibitors has not been previously studied.Purpose. Evaluation of the toxicity of the anticancer drug alofanib (RPT835), allosteric inhibitor of fibroblast growth factor receptor 2 type (FGFR2), in standard experimental in-vivo models in rodents and non-rodents.Material and methods. The general toxic effect of the alofanib was studied in an acute and chronic experiment on outbred animals (rats and rabbits) of both sexes. An experimental study was conducted in accordance with the ethical principles of handling laboratory animals.Results. The assumption that inhibition of FGFR2 provides a low level of toxicity has been proved. It was established that alofanib belongs to the 4 class of low-toxic chemical substances according to the classification of hazard levels of toxic effects of drugs and to the low-risk drugs by the value of the index of the therapeutic action, as well as to the 3 class (low-toxic drugs) according to the class of hazards for clinical application. Alofanib doesn»t cause allergenic and immunotoxic effects as well as doesn»t have pyrogenic properties. Increase of phosphates level (class-specific adverse effect of FGFR2 inhibitors) was statistically significant but less evident. During the study was noticed such an adverse effect as inhibition of spermatogenesis.Conclusion. Alofanib belongs to the classes of low-hazard and low-toxic chemicals and can be studied in a clinical study.Актуальность. Ингибирование рецептора фактора роста фибробластов 2 типа (ФРФР2) представляется целесообразным у больных с опухолями, экспрессирующими или амплифицирующими ФРФР2. Токсичность аллостерических ингибиторов ФРФР2 ранее не изучалась.Цель исследования. Оценка токсичности противоопухолевого препарата алофаниб (RPT835), аллостерического ингибитора рецептора фактора роста фибробластов 2 типа (ФРФР2), в стандартных экспериментальных моделях in vivo на грызунах и негрызунах.Материалы и методы. Общетоксическое действие препарата было изучено в остром и хроническом эксперименте на беспородных животных (крысах и кроликах) обоего пола. Экспериментальное исследование было проведено в соответствии с этическими принципами обращения с лабораторными животными.Результаты. Предположение о том, что ингибирование только одного рецептора ФРФР2 обеспечит низкий уровень токсичности, подтвердилось. Установлено, что алофаниб относится к 4 классу малотоксичных химических веществ по классификации степени опасности токсического действия лекарственных средств и к малоопасным лекарственным препаратам по величине индекса широты терапевтического действия, а также к 3 классу (малотоксичный лекарственный препарат) в соответствии с классом опасности для клинического применения. Алофаниб не оказывает аллергизирующего и иммунотоксичного действия и не обладает пирогенными свойствами. Увеличение уровня фосфатов (класс-специфического нежелательного явления ФРФР ингибиторов) было статистически достоверным, но маловыраженным. В исследовании отмечен такой побочный эффект как угнетение сперматогенеза.Заключение. Алофаниб относится к классам малоопасным и малотоксичных химических веществ и может изучаться в клиническом исследовании

STUDYING OF COMORBID PATHOLOGY AT THE 2 TYPES DIABETES AS THE COMPLICATION OF THE METABOLIC SYNDROME

Purpose. To define features of comorbid pathology at patients with a 2 types diabetes, to estimate a possibility of use of indexes of a comorbid pathology in the management of these patients. Materials and methods. Patients with a 2 types diabetes participated in a research. The retrospective analysis of medical records with calculation of indexes of a comorbid pathology for the systems CIRS, Kaplan-Feinstein, Charlson was made. Taking into account the received indexes at patients prognostic indicators of percentage risk of lethality within the next year and 10-year survival were defined. Correlation interrelations between laboratory indicators of components of a metabolic syndrome and values of indexes of a a comorbid pathology are defined. Results. It was defined that in structure of comorbid pathology at the chosen patients diseases of cardiovascular, nervous and genitourinary systems prevail. Besides the specified systems, at women specific gravity of pathology of endocrine system is big. With age the tendency to prevalence of comorbid pathology of the specified systems remains and also the augmentation of average score of indexes of a comorbid pathology on all systems, deterioration in prognostic indicators is taped. Statistically significant direct link between indexes of a comorbid pathology and separate components of a metabolic syndrome, an experience of a disease of patients is also taped

The efficacy and safety of corneal collagen cross-linking in progressive keratoconus with regard to long-term results

Purpose. To evaluate the efficacy and safety of a modified technique of corneal collagen cross-linking in comparison with the standard approach by the nature changes in clinical and morphological parameters of the cornea in the early and longterm postoperative period.Material and methods. The study included two groups of patients: the group 1 consisted of patients operated on for progressive keratoconus in the classical way of corneal collagen cross-linking – 25 individuals (25 eyes), the group 2 – patients treated by the modified cross-linking technique – 36 individuals (36 eyes). Before and after the procedure in the follow-up of 1, 3, 6 and 12 months, all patients underwent an extended ophthalmic examination, including the optical coherence tomography (OCT) of the cornea (Cirrus HD 3000, Carl Zeiss, Germany), the confocal microscopy (Confoscan4, Nidek, Japan).Results. Re-epithelialization of the cornea occurred faster in the group 2. In both investigated groups a significant UCVA increase (from 0.15±0.04 to 0.35±0.07 in the group 1 and 0.13±0.025 to 0.33±0.04 in the group 2) and the BCVA (from 0.3±0.08 to 0.5±0.05 in the group 1 and 0.4±0.04 to 0.87±0.18 in the group 2) was noted in the follow-up period of 6-12 months. After 1 month postoperatively the well-defined linear opacities in the middle and posterior layers of the stroma – the so-called «demarcation lines» or «posterior stromal hazes» appeared during the ophthalmic bio-microscopy as well as in the OCT of cornea in all observed patients. In this period the depth of the «demarcation line» position in the group 1 averaged 252±15.0μm, in the group 2 – 235±10.0μm. The confocal microscopy showed that histomorphological changes were more pronounced in the group 1 within all above-mentioned periods. In the 3-month follow-up in the group 2 a statistically significant reduction in our proposed scoring estimation of all the studied signs, and a maintenance of this trend were detected in the follow-up period after 6 and 12 months, that indicates a more mild and rapid regeneration of cornea after the corneal collagen cross-linking surgery performed according to the modified technique. The endothelial cells density (ECD) remained unchanged in all followup periods in both groups.Conclusions. Thus, a manifestation of positive dynamics in the postoperative UCVA, BCVA and the unchanged ECD in all cases allows to consider both options of corneal collagen crosslinking safe, with a comparable clinical efficacy. However, a more pronounced positive dynamics in the BCVA in the group 2, a milder course of the early postoperative period for patients, consisting in a more rapid completion of the re-epithelialization process, as well as and the availability of adequate and safe level histomorphological changes in the cornea after the cross-linking enable to recommend the modified technique for the treatment of progressive keratoconus

Students virtual and social identity in the process of humanities study: The problems of its correction

© 2016, Econjournals. All rights reserved.The relevance of the research problem is reasoned by global use of Internet technologies, altering the forms of personal self-identification: Atransition of the external world and human individuality in a digital code, the creation of informational imprint in space of the worldwide web, the alienation of the student youth in society, the substitution of reality by virtual world. In this direction a significant potential belongs to humanities, studying of which contributes to the interpenetration and mutual reinforcement of students’ social and virtual identification based on universal norms, values, value orientations, correction of virtual identity redundancy in real society. This article is aimed at scientifically-methodical substantiation of structure and content of pedagogical correction of higher school students’ self-identification in the process of humanities’ study. The leading method in this problem study is a method of modeling of the structure and content of students’ self-identification pedagogical correction in the process of humanitarian disciplines’ study. The article presents the theoretical and methodological foundations of the design and implementation of student’s social and virtual identity correction’s model, its discursive content and mechanisms, structure and new forms’ content in the process of humanities’ study. The presented materials in the article contribute to evidence-based correction of students virtual and social identity in the process of humanities’ study and are recommended to use for teachers, methodologists, university information departments’ programmers, improvement of qualification and teacher retraining courses’ attendants

Students virtual and social identity in the process of humanities study: The problems of its correction

© 2016, Econjournals. All rights reserved.The relevance of the research problem is reasoned by global use of Internet technologies, altering the forms of personal self-identification: Atransition of the external world and human individuality in a digital code, the creation of informational imprint in space of the worldwide web, the alienation of the student youth in society, the substitution of reality by virtual world. In this direction a significant potential belongs to humanities, studying of which contributes to the interpenetration and mutual reinforcement of students’ social and virtual identification based on universal norms, values, value orientations, correction of virtual identity redundancy in real society. This article is aimed at scientifically-methodical substantiation of structure and content of pedagogical correction of higher school students’ self-identification in the process of humanities’ study. The leading method in this problem study is a method of modeling of the structure and content of students’ self-identification pedagogical correction in the process of humanitarian disciplines’ study. The article presents the theoretical and methodological foundations of the design and implementation of student’s social and virtual identity correction’s model, its discursive content and mechanisms, structure and new forms’ content in the process of humanities’ study. The presented materials in the article contribute to evidence-based correction of students virtual and social identity in the process of humanities’ study and are recommended to use for teachers, methodologists, university information departments’ programmers, improvement of qualification and teacher retraining courses’ attendants