Modeling of matrix of correspondences of transactivator on example of the Yekaterinburg municipal unitary enterprise "Tram and trolleybus management"

Настоящая статья посвящена исследованию пассажиропотока транспортной сети городского электротранспорта г. Екатеринбурга на примере ЕМУП «Трамвайно-троллейбусное управление». Разработано программное приложение для анализа транзакциопотока трамвайно-троллейбусной сети в виде матрицы корреспонденций. Приложение c помощью SQL запросов формирует отчет в виде таблицы, результаты которой позволяют построить графы перемещения пассажиров между административными районами и внутри их. Графическое представление результатов анализа транзакциопотока визуализирует аналитическую обработку статистических данных об использовании городского электротранспорта в различных районах г. Екатеринбурга.This article is dedicated to research of urban passenger of a transport network electric transport Yekaterinburg on the example of municipal unitary enterprise "Tram and trolleybus management". Programmatic application is worked out for the analysis of transactivator of tram-car-trolleybus network as a matrix of correspondences. Appendix a report forms the c help of SQL of queries as a table the results of that allow to build the columns of moving of passengers between administrative districts and into them. Graphic presentation of results of analysis of transactivator visualizes the analytical processing of statistical data about the use of municipal electric transport in different districts Yekaterinburg

Brechas socioculturales y las formas de su eliminación durante el estudio de lenguas extranjeras

In order to take part in the intercultural communication of students, an idea of ​​national traditions, cultural values, customs, and realities of the studied language country must be developed. Lacunae are the gaps in knowledge of the country and the people culture who speak the language being studied. When you work with lacunae, it is necessary to check the correct understanding of their meaning constantly, as well as introduce them into the active vocabulary of students. This is why this study seeks to address the sociocultural gaps and the ways of transfer during the study of foreign languages.Para participar en la comunicación intercultural de los estudiantes, se debe desarrollar una idea de las tradiciones nacionales, los valores culturales, las costumbres y las realidades del país de la lengua estudiada. Las lagunas son las lagunas en el conocimiento del país y la cultura de las personas que hablan el idioma que se estudia. Cuando trabajas con lagunas, es necesario verificar constantemente la comprensión correcta de su significado, así como introducirlos en el vocabulario activo de los estudiantes. Es por esto que este estudio busca tratar la Brechas socioculturales y las formas de su eliminación durante el estudio de lenguas extranjera

Pathology of mammary glands in women with reproductive disorders and chronic endometritis

Background. The last decades are devoted to the search for various factors leading to the development of benign breast diseases, which are the risk of breast cancer. In gynecological diseases, the frequency of benign processes in the mammary glands increases to 76-97.8 %. Aims: this research is devoted to the study of the prevalence and structure of breast pathology in women with chronic endometritis and reproductive disorders. Materials and methods. The study included patients with reproductive disorders: 50 patients with histological verification of the diagnosis of chronic endometritis and 50 patients without chronic endometritis. Hormonal examination was carried out using radioimmunoassay and immunoenzymatic methods. Methods of mathematical statistics implemented Statistica 6.1 (USA) were used parametric criteria: Student's t-test and Fisher's F-criterion, the nature of the distribution was estimated using the methods of Kolmogorov - Smirnov with a significance level smaller and equal to 5 % (p < 0.05). To confirm the fact that the observed differences between the products of A x D and B x C are not random, we used the х2 criterion. Results and conclusions. In women with chronic endometritis, the pathology of the mammary glands is characterized by the presence of ectasia of the ducts of the mammary gland; clinically, it is manifested by lactorrhea. Benign dysplasia of mammary glands is accompanied by the presence of hyperestrogenia, hypoprogesteronemia, which is typical for ovarian dysfunction. It is possible to use a pathogenetically reasonable combination correction: anti-inflammatory therapy and the use of gestagens in women with reproductive disorders and chronic endometritis

Sleep features in menopausal women (literature review)

The article reviews the literature of domestic and foreign researchers devoted to the somnological aspects of the menopausal period in women. Age-related changes in the structural organization of sleep are shown with a deficiency of sex steroids, also and in the gender aspect. A high frequency of sleep disorders in menopausal women, reaching 60 %, has been revealed. However, the results of studies on complaints of sleep disorders depending on the climacteric phase are ambiguous, which may be due to ethnicity. Data on some pathogenetic mechanisms of the formation of the most frequent sleep disorders in menopausal women - insomnia, obstructive sleep apnea syndrome and fibromyalgia - are described. The results of polysomnography in these pathological states are presented, indicating a decrease in sleep efficiency, a change in its "architecture", and a longer waking time during the night with insomnia; a significant increase in the apnea/hypopnea index, a delay in the phase of fast sleep, a decrease in the duration of deep stages of sleep and a decrease in its effectiveness - in obstructive sleep apnea syndrome. The social and medical consequences of sleep disorders and their comorbidity with such pathological conditions as mental disorders, obesity, cardiovascular diseases, oncology, disorders of carbohydrate metabolism, bronchial asthma, mortality are noted

Arterial Hypertension and Severe COVID-19 in Hospitalized Patients: Data from a Cohort Study

Aim. To assess the association  of hypertension  with the severe forms and fatal outcomes of Coronavirus disease 2019 (COVID-19).Material and Methods. This retrospective  cohort study involved adult patients (≥18 years old),  admitted to the University  hospital №4 of Sechenov University (Moscow, Russia) between 08 April 2020 and 19 November 2020 with clinically diagnosed or laboratory-confirmed COVID-19. The cohort included 1637 patients. The primary outcome was all-cause in-hospital mortality. The secondary outcomes included intensive care unit admission (ICU) and invasive ventilation. Multiple logistic regression was performed to assess the independent association  between risk factors and endpoints.Results. A total of 1637 patients were included in the study. 51.80% (n=848) of the subjects were males. The median age was 59.0 (48.0; 70.0) years and 55.90% (n=915) had pre-existing diagnosis of hypertension. Patients with hypertension  had significantly more severe lung injury based on chest CT scan findings  as well as lower oxygen saturation  (SрO2). More of them were admitted to ICU  and  placed  on invasive  ventilation.  The hypertension  group  also  had  higher  mortality.  Age,  hypertension, glucose, C-reactive protein and decreased platelet count were independently associated with mortality, hypertension  having the strongest association (OR 1.827, 95% CI 1.174-2.846, p=0.008). Age,  hypertension, neutrophil count, platelet count, glucose, and CRP were independently associated  with ICU  admission, with hypertension  having  the strongest  association  (OR  1.595, 95% CI 1.178-2.158, p=0.002). Age, hypertension, glucose, CRP and decreased platelet count were independently associated with invasive ventilation, with hypertension having the strongest association  (OR  1.703, 95% CI 1.151-2.519, p=0.008).Based on the multiple logistic regression models, odds of death, ICU admission, and invasive ventilation were higher in the hypertension  group as compared  to the group without hypertension.Conclusion. Hypertension can be an independent predictor of severe COVID-19 and adverse outcomes, namely death, ICU admission, and invasive ventilation in hospitalized  patients

ESTIMATION OF EFFICIENCY OF A TECHNIQUE OF TRANSVAGINAL PUNCTURES OF OVARIES WITH WASHING OF FOLLICLES IN IVF CYCLES

«Poor» ovarian response in standard IVF protocols leads to the difficulty or even impossibility of ensuring the stage of transfer of embryos. A technique of transvaginal puncture with washing of follicles by buffer solution is performed in patients with «poor» ovarian response. This article presents the analysis of TVP in 495 IVF initiated treatment cycles. A smaller number of mature oocytes and embryos are received in the process of controlled ovarian hyperstimulation in patients with washing of follicles, however, the possibility of pregnancy is comparable to the overall IVF results

Towards surface quantum optics with Bose-Einstein condensates in evanescent waves

We present a surface trap which allows for studying the coherent interaction of ultracold atoms with evanescent waves. The trap combines a magnetic Joffe trap with a repulsive evanescent dipole potential. The position of the magnetic trap can be controlled with high precision which makes it possible to move ultracold atoms to the surface of a glass prism in a controlled way. The optical potential of the evanescent wave compensates for the strong attractive van der Waals forces and generates a potential barrier at only a few hundred nanometers from the surface. The trap is tested with Rb Bose-Einstein condensates (BEC), which are stably positioned at distances from the surfaces below one micrometer

System Approach to the Development of Intelligent Complexes of Oncological Diagnostics

The system approach to the development of intellectual complexes in cancer diagnosis are discussed in the article. Distinctive features of this approach: the participation of pathologist at the stage of description of recognizable images (the description is based on traditional assessments of quality informative features of tumors); the set of the most similar probabilistic diagnoses is forming on the classification stage of recognition; final histological diagnosis is made by pathologist. The proposed approach has been successfully tested in clinical practice. Keywords: image processing, image description, image classification, pattern recognition, qualitative attributes of tumor images, interactive recognition, cancer diagnosis, decision support syste

Species diversity of Trichoderma in Poland

In the present study, we reinvestigate the diversity of Trichoderma in Poland utilizing a combination of morphological and molecular/phylogenetic methods. A total of 170 isolates were collected from six different substrata at 49 sites in Poland. These were divided among 14 taxa as follows: 110 of 170 Trichoderma isolates were identified to the species level by the analysis of their ITS1, ITS2 rDNA sequences as: T. harzianum (43 isolates), T. aggressivum (35), T. citrinoviride (11), T. hamatum (9), T. virens (6), T. longibrachiatum (4), T. polysporum (1), and T. tomentosum (1); 60 isolates belonging to the Viride clade were identified based on a fragment of the translation-elongation factor 1-alpha (tef1) gene as: T. atroviride (20 isolates), T. gamsii (2), T. koningii (17), T. viridescens (13), T. viride (7), and T. koningiopsis (1). Identifications were made using the BLAST interface in TrichOKEY and TrichoBLAST (http://www.isth.info). The most diverse substrata were soil (nine species per 22 isolates) and decaying wood (nine species per 75 isolates). The most abundant species (25%) isolated from all substrata was T. harzianum

Vitamin D (steroid hormone) and the nervous system diseases (literature review)

The present review aims to summarize the activities of vitamin D effects on the nervous system and to clarify a vitamin D role in brain diseases, in the pathogenesis or as a serum biomarker for the disease development and severity. Objective: correlation between chronic nervous system diseases and vitamin D level. Methods: a literature research in PubMed and in Russian electronic resources by keywords: vitamin D, brain diseases, chronic nervous system diseases. Results. Vitamin D as a neurosteroid hormone stimulates cerebral activity in both adult and embryonic brain regulates the activity of neural circuits which are responsible for locomotor, reward-dependent and emotional behavior. Patients with autism spectrum disorders, schizophrenia, Alzheimer disease, multiple sclerosis, Parkinson disease and sleep disorders have been shown to have low level of vitamin D. Discussion. Data are controversial, a further study of vitamin D hypovitaminosis significance is essential for the nervous system chronic diseases manifestation and evaluation of the vitamin D dietary supplement efficiency in patients with the nervous system pathology