19,277 research outputs found
The Multiplicative Inverse Eigenvalue Problem over an Algebraically Closed Field
Let be a square matrix and let be a monic polynomial of degree
. Let be a set of matrices. The multiplicative inverse
eigenvalue problem asks for the construction of a matrix in such that the
product matrix has characteristic polynomial . In this paper we
provide new necessary and sufficient conditions when is an affine variety
over an algebraically closed field.Comment: 9 Page
Pinning control of fractional-order weighted complex networks
In this paper, we consider the pinning control problem of fractional-order weighted complex dynamical networks. The well-studied integer-order complex networks are the special cases of the fractional-order ones. The network model considered can represent both directed and undirected weighted networks. First, based on the eigenvalue analysis and fractional-order stability theory, some local stability properties of such pinned fractional-order networks are derived and the valid stability regions are estimated. A surprising finding is that the fractional-order complex networks can stabilize itself by reducing the fractional-order q without pinning any node. Second, numerical algorithms for fractional-order complex networks are introduced in detail. Finally, numerical simulations in scale-free complex networks are provided to show that the smaller fractional-order q, the larger control gain matrix D, the larger tunable weight parameter , the larger overall coupling strength c, the more capacity that the pinning scheme may possess to enhance the control performance of fractional-order complex networks
Research on Safety and Security Distance of Flammable Liquid Storage Tank
AbstractFlammable liquid storage tanks usually plant a potential dangerous zone. The damage gets worse and worse. In order to avoid the tank fire, the tanks extended to the nearby storage tanks-facilities and buildings. In consideration of safety conditions, flammable liquid storage tanks for the safety and security distance is necessary. Through the FDS (Fire Dynamics Simulator) computer simulation of fire, flammable liquid storage tanks for spot the fires numerical simulation to detect a fire to happen. In order to establish an optimized model, the flammable liquid storage tanks save the temperature distribution by obtaining flammable safety distance of the liquid storage tank, by talking about the current laws and regulations, by looking forward to meeting the economic and security considerations
Multiobjective synchronization of coupled systems
Copyright @ 2011 American Institute of PhysicsSynchronization of coupled chaotic systems has been a subject of great interest and importance, in theory but also various fields of application, such as secure communication and neuroscience. Recently, based on stability theory, synchronization of coupled chaotic systems by designing appropriate coupling has been widely investigated. However, almost all the available results have been focusing on ensuring the synchronization of coupled chaotic systems with as small coupling strengths as possible. In this contribution, we study multiobjective synchronization of coupled chaotic systems by considering two objectives in parallel, i. e., minimizing optimization of coupling strength and convergence speed. The coupling form and coupling strength are optimized by an improved multiobjective evolutionary approach. The constraints on the coupling form are also investigated by formulating the problem into a multiobjective constraint problem. We find that the proposed evolutionary method can outperform conventional adaptive strategy in several respects. The results presented in this paper can be extended into nonlinear time-series analysis, synchronization of complex networks and have various applications
Suprarenal aortic clamping and reperfusion decreases medullary and cortical blood flow by decreased endogenous renal nitric oxide and PGE2 synthesis
ObjectiveThis study examined the hypothesis that clamping the aorta above the superior mesenteric artery (SMA) followed by suprarenal aortic clamping and reperfusion (SRACR) decreases microvascular blood flow by loss of endogenous medullary and cortical nitric oxide (NO) and prostaglandin (PG) E2 synthesis.Study DesignAnesthetized male Sprague-Dawley rats (350 g) had either microdialysis probes or laser Doppler fibers inserted into the renal cortex to a depth of 2 mm and into the renal medulla at 4 mm. Laser Doppler blood flow was continuously monitored (data reported as percentage of change compared to basal), and the microdialysis probes were connected to a syringe pump and perfused in vivo at 3 μL/min with lactated Ringer solution. Dialysate fluid was collected at basal time zero, following 30 minutes of suprarenal aortic clamping (ischemia) followed by 60 minutes of reperfusion and compared to a sham operation. Both groups were treated with saline carrier, indomethacin (INDO) (10 mg/kg, a cyclooxygenase [COX] inhibitor), NG-nitro-l-arginine methyl ester (l-NAME) (20 mg/kg, a NO synthase [NOS] inhibitor), or l-arginine (200 mg/kg, an NO precursor). Dialysate was analyzed for total NO (μM) and PGE2 (pg/mL) synthesis. The renal cortex and medulla were analyzed for inducible NOS (iNOS) and COX-2 content by Western blot. All data are reported as mean ± SEM, N > 5 and analyzed by analysis of variance.ResultsSRACR caused a marked decrease in medullary and cortical blood flow with a concomitant decrease in endogenous medullary and cortical NO synthesis. Treatment with l-NAME further decreased blood flow and NO synthesis in the medulla and cortex. l-Arginine restored medullary and cortical NO synthesis and blood flow in the cortex but not the medulla. SRACR did not alter renal medullary or cortical PGE2; however, addition of INDO, COX inhibitor, caused a concomitant decrease in medullary and cortical PGE2 synthesis and blood flow.ConclusionsNO is an important endogenous renal vasodilator that, when maintained can help preserve cortical blood flow following SRACR. These data also suggest that avoidance of COX-2 inhibitors can help maintain endogenous renal cortical and medullary PGE2 synthesis and thus contribute to maintaining normal blood flow.Clinical RelevanceThis study is the first to combine in vivo physiologic assays to simultaneously identify clinically relevant intrarenal vasodilators (cortical and medullary) that are required to maintain microvascular blood flow. Identification of endogenous renal cortical and medullary vasodilators responsible for maintaining renal microvascular blood flow will allow development of treatment strategies to preserve these vasodilators following SRACR. Successful preservation of endogenous intrarenal vasodilators will help maintain renal microvascular blood flow and renal function in the treatment of complex aortic pathology that requires SRACR
Masked Gradient-Based Causal Structure Learning
This paper studies the problem of learning causal structures from
observational data. We reformulate the Structural Equation Model (SEM) in an
augmented form with a binary graph adjacency matrix and show that, if the
original SEM is identifiable, then this augmented form can be identified up to
super-graphs of the true causal graph under mild conditions. Three methods are
further provided to remove spurious edges to recover the true graph. We next
utilize the augmented form to develop a masked structure learning method that
can be efficiently trained using gradient-based optimization methods, by
leveraging a smooth characterization on acyclicity and the Gumbel-Softmax
approach to approximate the binary adjacency matrix. It is found that the
obtained entries are typically near zero or one, and can be easily thresholded
to identify the edges. We conduct experiments on synthetic and real datasets to
validate the effectiveness of the proposed method and show that the method can
readily include different smooth functions to model causal relationships
A Bayesian measurement error model for two-channel cell-based RNAi data with replicates
RNA interference (RNAi) is an endogenous cellular process in which small
double-stranded RNAs lead to the destruction of mRNAs with complementary
nucleoside sequence. With the production of RNAi libraries, large-scale RNAi
screening in human cells can be conducted to identify unknown genes involved in
a biological pathway. One challenge researchers face is how to deal with the
multiple testing issue and the related false positive rate (FDR) and false
negative rate (FNR). This paper proposes a Bayesian hierarchical measurement
error model for the analysis of data from a two-channel RNAi high-throughput
experiment with replicates, in which both the activity of a particular
biological pathway and cell viability are monitored and the goal is to identify
short hair-pin RNAs (shRNAs) that affect the pathway activity without affecting
cell activity. Simulation studies demonstrate the flexibility and robustness of
the Bayesian method and the benefits of having replicates in the experiment.
This method is illustrated through analyzing the data from a RNAi
high-throughput screening that searches for cellular factors affecting HCV
replication without affecting cell viability; comparisons of the results from
this HCV study and some of those reported in the literature are included.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS496 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Three-dimensional correlated-fermion phase separation from analysis of the geometric mean of the individual susceptibilities
A quasi-Gaussian approximation scheme is formulated to study the strongly
correlated imbalanced fermions thermodynamics, where the mean-field theory is
not applicable. The non-Gaussian correlation effects are understood to be
captured by the statistical geometric mean of the individual susceptibilities.
In the three-dimensional unitary fermions ground state, an {\em universal}
non-linear scaling transformation relates the physical chemical potentials with
the individual Fermi kinetic energies. For the partial polarization phase
separation to full polarization, the calculated critical polarization ratio is
. The defines
the ratio of the symmetric ground state energy density to that of the ideal
fermion gas.Comment: Minor changes with typos correcte
Crystallization of Adenylylsulfate Reductase from Desulfovibrio gigas: A Strategy Based on Controlled Protein Oligomerization
Adenylylsulfate reductase (adenosine 5′-phosphosulfate reductase, APS reductase or APSR, E.C.1.8.99.2) catalyzes the conversion of APS to sulfite in dissimilatory sulfate reduction. APSR was isolated and purified directly from massive anaerobically grown Desulfovibrio gigas, a strict anaerobe, for structure and function investigation. Oligomerization of APSR to form dimers–α_2β_2, tetramers–α_4β_4, hexamers–α_6β_6, and larger oligomers was observed during purification of the protein. Dynamic light scattering and ultracentrifugation revealed that the addition of adenosine monophosphate (AMP) or adenosine 5′-phosphosulfate (APS) disrupts the oligomerization, indicating that AMP or APS binding to the APSR dissociates the inactive hexamers into functional dimers. Treatment of APSR with β-mercaptoethanol decreased the enzyme size from a hexamer to a dimer, probably by disrupting the disulfide Cys156—Cys162 toward the C-terminus of the β-subunit. Alignment of the APSR sequences from D. gigas and A. fulgidus revealed the largest differences in this region of the β-subunit, with the D. gigas APSR containing 16 additional amino acids with the Cys156—Cys162 disulfide. Studies in a pH gradient showed that the diameter of the APSR decreased progressively with acidic pH. To crystallize the APSR for structure determination, we optimized conditions to generate a homogeneous and stable form of APSR by combining dynamic light scattering, ultracentrifugation, and electron paramagnetic resonance methods to analyze the various oligomeric states of the enzyme in varied environments
Visualization of HIFU-induced lesions with thermoacoustic tomography
High-intensity focused ultrasound (HIFU) has proved to be an effective minimally invasive surgical technology. In this study, we focus on the visualization of HIFU-induced lesions using microwave-induced thermoacoustic tomography (TAT). TAT has high spatial resolution, comparable with ultrasound imaging, and high contrast, which is induced by differences in the microwave absorption rates between tumor tissue and normal tissue. TAT can, in addition, differentiate tumors before and after treatment. A single, spherically focused transducer operating at a center frequency of approximately 4 MHZ was used to generate the focused field. The lesion was generated in porcine muscle. A local-tomography-type reconstruction algorithm was applied to reconstruct the TAT image of the lesions. The lesion shown by gross pathology confirms the corresponding region measured by TAT
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