eine ethnographische Annäherung

Wie denken BerlinerInnen über die Zukunft ihrer Stadt? Was sind ihre Wünsche, was mögliche Zukunftsängste? Studierende des Masterstudiums Zukunftsforschung haben Antworten auf diese Fragen gesucht und sich in verschiedenen Milieus der Stadt aufgehalten, um – angelehnt an den ethnographischen Ansatz der teilnehmenden Beobachtung – mit den Menschen vor Ort intensive Gespräche zu führen. Sechs Gruppen standen dabei im Fokus: die Gäste und BetreiberInnen alteingesessener Kneipen in Berliner Szenekiezen, TaxifahrerInnen, BewohnerInnen eines Mehrfamilienhauses in Berlin-Pankow, homosexuelle Männer, VerkäuferInnen des Obdachlosenmagazins »Straßenfeger« sowie junge UnternehmerInnen aus dem Bereich der »Social Startups«. Herausgekommen sind einzigartige Blicke auf die Zukunft Berlins, die aus teilweise vernachlässigten Perspektiven vielfältige Hoffnungen, Erwartungen und Ängste von BerlinerInnen zeigen. Die »Gespräche« zeigen, dass die von ihrer jeweils eigenen Geschichte und sozialen Gegenwart geprägten »subkulturellen« Zukunftsbilder eine elementare Rolle für die Wahrnehmung von Berlin spielen. Zentral in allen Zukunftsvorstellungen ist dabei die Auseinandersetzung mit dem zukünftigen Zusammenleben unter den Bedingungen eines sich stetig wandelnden sozialen Umfelds. Das Konzept und die Umsetzung entstand im Wintersemester 2014/15 in einer Übung im »Einsatzfeld Gesellschaft« des Masterstudiengangs Zukunftsforschung an der Freien Universität Berlin, geleitet von Björn Theis

Land-use in Amazonia and the cerrado of Brazil.

The total area and annual rate of native vegetation clearing is greatest in the Cerrado region followed by the Brazilian states of Para, Mato Grosso, Maranhao and Rondonia. Amazonian forest clearing proceeds most quickly where abundant natural resources (wood or land) are accessible by roads and close to markets. These regions are concentrated along the eastern and southern flanks of Amazonia, particularly in eastern Para, Cuiaba and Rondonia. There are still large discrepancies in estimates of annual deforestation; Landsat (Thematic Mapper-based) mapping of deforestation in the closed-canopy forests of Amazonia has not include non-Brazilian countries and is incomplete for the cerrado biome. Amazonian deforestation was last mapped 1994. Current estimates of Amazonian forest clearing do not include most of the forests that are affected by logging each year, which is an area (about 7,000 km2 yr-1)more than half the size of the area of annual deforestation. Logging changes forest structure and increases forest flammability. The intensity of logging ranges from 1-to 100-species harvest, and averages 20m3 of wood harvested per hectare. Logging may increase dramatically in the coming years. Fire affects large, but difficult to measure, areas of pastureland, logged forests, secondary forests and primary forests. Forest ground fires are particularly difficult to map fom satellite data. Fire is more frequent where forest clearing is taking place, and where seasonal drought is most severe. The destiny of Amazonian forest land cleared for crops and cattle pasture is complex, and highly variables regionally. Areal estimates are needed for managed pasture, degraded pasture, cropland and secondadry forests, for these ecosystems are functionally distinct. Most forest clearing is for pasture establishment, followed by shifting cultivation. Cattle pasture is the logical land-use for both small-scale and large-scale rural Amazonians because cattle are easily sold or traded, and they maintain their value during inflation. Cattle patures help secure land claims and increase land value. In the Cerrado, there has been a shift from extensive cattle grazing of natural savannas to pasture planted with African forage grasses; mechanized soy bean production is the second most extensive land-use. Pastures are the most important land-cover for the LBA (Large-Scale Biosphere - Atmosphere experiment in Amazonia) science campaign. Brazilian Amazonia experiences reduced rainfall during ENSO events. ENSO-related drought is most severe in eastern Amazonia. A basin-wide reduction in rainfall would have its greatest affect on vegetation near the border between savanna and closed-canopy forest in Rondonia, Mato Grosso, Para and Tocantins. The LBA campaign should be conducted in variety of rural landscapes to capture the multiplicity of human effects on native ecosystems, as well as the range of cliamatic and edaphic conditions under which these ecosystems have evolved. It should address the current (ENSO) and predicted variations in climate, and should be designed to recommend those land-uses that best reconcile the maintenance of ecosystem processes with socially equitable economic growth

Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters

3,4-Methylendioxymethamphetamine (MDMA) has both stimulatory and hallucinogenic properties which make its psychoactive effects unique and different from those of typical psychostimulant and hallucinogenic agents. The present study investigated the effects of MDMA on extracellular dopamine (DAex) and serotonin (5-HTex) levels in the striatum and prefrontal cortex (PFC) using in vivo microdialysis techniques in mice lacking DA transporters (DAT) and/or 5-HT transporters (SERT). subcutaneous injection of MDMA (3, 10 mg/kg) significantly increased striatal DAex in wild-type mice, SERT knockout mice, and DAT knockout mice, but not in DAT/SERT double-knockout mice. The MDMA-induced increase in striatal DAex in SERT knockout mice was significantly less than in wildtype mice. In the PFC, MDMA dose-dependently increased DAex levels in wildtype, DAT knockout, SERT knockout and DAT/SERT double-knockout mice to a similar extent. In contrast, MDMA markedly increased 5-HTex in wildtype and DAT knockout mice and slightly increased 5-HTex in SERT-KO and DAT/SERT double-knockout mice. The results confirm that MDMA acts at both DAT and SERT and increases DAex and 5-HTex

Noncollinear magnetic ordering in small Chromium Clusters

We investigate noncollinear effects in antiferromagnetically coupled clusters using the general, rotationally invariant form of local spin-density theory. The coupling to the electronic degrees of freedom is treated with relativistic non-local pseudopotentials and the ionic structure is optimized by Monte-Carlo techniques. We find that small chromium clusters (N \le 13) strongly favor noncollinear configurations of their local magnetic moments due to frustration. This effect is associated with a significantly lower total magnetization of the noncollinear ground states, ameliorating the disagreement between Stern-Gerlach measurements and previous collinear calculations for Cr_{12} and Cr_{13}. Our results further suggest that the trend to noncollinear configurations might be a feature common to most antiferromagnetic clusters.Comment: 9 pages, RevTeX plus .eps/.ps figure

The onset of magnetic order in fcc-Fe films on Cu(100)

On the basis of a first-principles electronic structure theory of finite temperature metallic magnetism in layered materials, we investigate the onset of magnetic order in thin (2-8 layers) fcc-Fe films on Cu(100) substrates. The nature of this ordering is altered when the systems are capped with copper. Indeed we find an oscillatory dependence of the Curie temperatures as a function of Cu-cap thickness, in excellent agreement with experimental data. The thermally induced spin-fluctuations are treated within a mean-field disordered local moment (DLM) picture and give rise to layer-dependent `local exchange splittings' in the electronic structure even in the paramagnetic phase. These features determine the magnetic intra- and interlayer interactions which are strongly influenced by the presence and extent of the Cu cap.Comment: 13 pages, 3 figure

A common genetic network underlies substance use disorders and disruptive or externalizing disorders

Here we summarize evidence obtained by our group during the last two decades, and contrasted it with a review of related data from the available literature to show that behavioral syndromes involving attention deficit/hyperactivity disorder (ADHD), externalizing disorders, and substance-use disorder (SUD) share similar signs and symptoms (i.e., have a biological basis as common syndromes), physiopathological and psychopathological mechanisms, and genetic factors. Furthermore, we will show that the same genetic variants harbored in different genes are associated with different syndromes and that non-linear interactions between genetic variants (epistasis) best explain phenotype severity, long-term outcome, and response to treatment. These data have been depicted in our studies by extended pedigrees, where ADHD, externalizing symptoms, and SUD segregate and co-segregate. Finally, we applied here a new formal network analysis using the set of significantly replicated genes that have been shown to be either associated and/or linked to ADHD, disruptive behaviors, and SUD in order to detect significantly enriched gene categories for protein and genetic interactions, pathways, co-expression, co-localization, and protein domain similarity. We found that networks related to pathways involved in axon guidance, regulation of synaptic transmission, and regulation of transmission of nerve impulse are overrepresented. In summary, we provide compiled evidence of complex networks of genotypes underlying a wide phenotype that involves SUD and externalizing disorders

Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here

First-Principles Dynamical Coherent-Potential Approximation Approach to the Ferromagnetism of Fe, Co, and Ni

Magnetic properties of Fe, Co, and Ni at finite temperatures have been investigated on the basis of the first-principles dynamical CPA (Coherent Potential Approximation) combined with the LDA (Local Density Approximation) + $U$ Hamiltonian in the Tight-Binding Linear Muffintin Orbital (TB-LMTO) representation. The Hamiltonian includes the transverse spin fluctuation terms. Numerical calculations have been performed within the harmonic approximation with 4th-order dynamical corrections. Calculated single-particle densities of states in the ferromagnetic state indicate that the dynamical effects reduce the exchange splitting, suppress the band width of the quasi-particle state, and causes incoherent excitations corresponding the 6 eV satellites. Results of the magnetization vs temperature curves, paramagnetic spin susceptibilities, and the amplitudes of local moments are presented. Calculated Curie temperatures ($T_{\rm C}$) are reported to be 1930K for Fe, 2550K for Co, and 620K for Ni; $T_{\rm C}$ for Fe and Co are overestimated by a factor of 1.8, while $T_{\rm C}$ in Ni agrees with the experimental result. Effective Bohr magneton numbers calculated from the inverse susceptibilities are 3.0 $\mu_{\rm B}$ (Fe), 3.0 $\mu_{\rm B}$ (Co), and 1.6 $\mu_{\rm B}$ (Ni), being in agreement with the experimental ones. Overestimate of $T_{\rm C}$ in Fe and Co is attributed to the neglects of the higher-order dynamical effects as well as the magnetic short range order.Comment: 10 pages, 13 figure