Representational momentum in the motor system?

PURPOSE: If presented with a moving object which suddenly disappears observers usually misjudge the object's last seen position as being further forward along the path of motion. This effect, called representational momentum, can also be seen in objects that change size or shape. It has been argued that the effect is due to perceptual anticipation. We tested whether a similar effect is present in the motor system. METHODS: Using stereo computer graphics we presented cubes of different sizes on a CRT monitor. In each trial three cubes were successively presented for 200 msec with increasing or decreasing size (steps of 1 cm width difference). Ten participants either compared the last cube to a comparison cube (perceptual task) or grasped the cube using a virtual haptic setup (motor task). The setup consisted of two robot arms (Phantom TM) attached to index finger and thumb. The robot arms were controlled to create forces equivalent to the forces created by real objects. The CRT monitor was viewed via a mirror such that the visual position of the cubes matched the position of the virtual haptic objects. RESULTS: In the motor task participants opened their fingers by 1.1+/-0.4 mm wider if they grasped a cube that was preceded by smaller cubes than if they grasped a cube that was preceded by larger cubes. This is the well-known representational momentum effect. In the perceptual task the effect was reversed (-2.2+/-0.4 mm). The effects correlated between observers (r=.71, p=.02). CONCLUSIONS: It seems that a representational momentum occurs also in grasping tasks. The correlation between observers suggests that the motor effect is related to the perceptual effect. However, our perceptual task showed a reversed effect. Reasons for this discrepancy will be discussed

Getting diverse students and staff to talk about integration on campus, and what they say when they do: A UK-India collaborative case study.

This paper reports the early stages of a UKIERI-funded project, ‘Widening Participation: Diversity, isolation or integration in Higher Education?’.The project is concerned with greater equity, social justice, community and social cohesion within the current globalised, market oriented context of higher education (HE), and with enabling students to be better prepared for, and thrive in social networks and work-related arenas which are increasingly diverse, multicultural, interdependent and global. The main aim of this 3 year project is to explore the nature of social cohesion, integration and separation, diversity, equality and discrimination experienced by diverse, minority, disadvantaged and under-represented students attending HE in UK and India. Group stereotypes are often subconsciously held, emerging into consciousness only when they appear confirmed or confounded by personal experience or public events. Where there is little knowledge or personal experience then reliance upon group stereotypes is more likely (Kunda & Thagard, 1996). This can impact upon student and staff expectations of, responses to, and interactions with each other. Individual students’ experiences and perceptions lie at the core of this project, but the ultimate purpose is to illuminate our understanding as to how these are mediated, shaped and formed, in relation to and in interaction with the structures and contextual features of the educational environments in which they, as students, are located. It is thus framed by socio-cultural rather than psychological or therapeutic theories and is located within a social-constructivist perspective (Moore, 2000). Social constructivism facilitates the development of improved understandings of educational and social environments that shape rather than determine individual dispositions towards social diversity encountered on campus. It is highly suited to the understanding of perceptions, and exploring resonances with actions, reactions and interactions. The initial stage of this project involved inviting students and staff (academic and support staff) from five HE colleges and universities in England and India to keep a record (written and photographic) of what for them seemed to be important and relevant events relating to what they saw, heard, did and experienced on campus for a period of 1 month, in teaching, learning and social situations; namely interactions in classes and social settings; what seem to be good experiences and what seem to be negative ones; how and if their particular knowledge and experiences were used, valued and incorporated into their HE experience and learning or how they were negated. A sample size of 90 record keepers was sought across the participating institutions. Getting that sample presented significant difficulties to all but one of the participating institutions, and raised questions about • the methods initially adopted, • the general willingness of students and staff to address and share issues relating to diversity, equality, social cohesion and integration on HE campuses with researchers • cultural differences in accessing respondents to take part in the research Additional data collection methods were adopted and by January 2009 the intended sample size almost met. This paper will address the problems encountered in undertaking the first stage of this research and present initial findings from the data that were eventually obtained

Urban environmental geochemistry of trace metals

Author name used in this publication: Coby S. C. Wong2005-2006 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

The history of the CATH structural classification of protein domains

This article presents a historical review of the protein structure classification database CATH. Together with the SCOP database, CATH remains comprehensive and reasonably up-to-date with the now more than 100,000 protein structures in the PDB. We review the expansion of the CATH and SCOP resources to capture predicted domain structures in the genome sequence data and to provide information on the likely functions of proteins mediated by their constituent domains. The establishment of comprehensive function annotation resources has also meant that domain families can be functionally annotated allowing insights into functional divergence and evolution within protein families

Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster.

Several components have been previously identified, that modulate longevity in several species, including the target of rapamycin (TOR) and the Insulin/IGF-1 (IIS) signalling pathways. In order to infer paths and transcriptional feedback loops that are likely to modulate ageing, we manually built a comprehensive and computationally efficient signalling network model of the IIS and TOR pathways in worms. The core insulin transduction is signalling from the sole insulin receptor daf-2 to ultimately inhibit the translocation of the transcription factor daf-16 into the nucleus. Reduction in this core signalling is thought to increase longevity in several species. In addition to this core insulin signalling, we have also recorded in our worm model the transcription factors skn-1 and hif-1, those are also thought to modulate ageing in a daf-16 independent manner. Several paths that are likely to modulate ageing were inferred via a web-based service NetEffects, by utilising perturbed components (rheb-1, let-363, aak-2, daf-2;daf-16 and InR;foxo in worms and flies respectively) from freely available gene expression microarrays. These included "routes" from TOR pathway to transcription factors daf-16, skn-1, hif-1 and daf-16 independent paths via skn-1/hif-1. Paths that could be tested by experimental hypotheses, with respect to relative contribution to longevity, are also discussed. Direct comparison of the IIS and TOR pathways in both worm and fly suggest a remarkable similarity. While similarities in the paths that could modulate ageing in both organisms were noted, differences are also discussed. This approach can also be extended to other pathways and processes

Are Foraging Patterns in Humans Related to Working Memory and Inhibitory Control?

In previous studies we have shown that human foraging patterns appear to be constrained by attention. However, we also noted clear individual differences in foraging ability, where some individuals can apparently keep more than one target template in mind during foraging. Here, we examine whether such individual differences relate to more general working memory capacity and/or the ability to inhibit a primed, or prepotent response. We had three main goals. First, to replicate general patterns of attention-constrained foraging. Second, to verify that some individuals appear immune to such constraints. Third, to investigate a possible link between individual foraging style and working memory abilities measured on a digit-span task and inhibitory control measured with a Stroop task. In sum, we replicated the finding that foraging differs greatly by whether foraging targets are defined by a single feature or a conjunction of features, but also again found that some observers show little differences in foraging between the two conditions, seemingly shifting with ease between search templates. In contrast, neither working memory nor Stroop performance were reliable predictors of these individual differences in foraging pattern. We discuss the implications of the findings for theories of visual attention.Peer Reviewe