9 research outputs found
Revealing the metabonomic variation of esophageal cancer using 1H-NMR spectroscopy and its association with the clinic pathological characteristics.
Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy
HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma
Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours