Design of a socio-economic processes monitoring system based on network analysis and big data

Socio-economic policy should satisfy the interests of the society as much as possible and contribute to improving the quality of life. This actualizes the role of developing the theoretical and methodological foundations for building an innovative information system for monitoring the socio-economic situation and population responses. The study built and tested an algorithm for supporting management decisions based on the collection of large data sets of socio-economic information based on the principles of the digital economy and processing them through network analysis. The algorithm is focused on building a monitoring system that presupposes a synergy of the authorities and the society, not only in its pensionary part, but also among the masses, which are diverse in their representativeness. The result of the study was the formation of a theoretical and methodological framework for creating a system for making management decisions and assessing the effectiveness of the activities of government bodies, based on the principles of reflection of the final beneficiaries of economic policy.peer-reviewe

Influence of peat formation conditions on the transformation of peat deposit organic matter

The paper studies the individual composition of n-alkanes, polycycloaromatic hydrocarbons, steroids, bi-, tri-, and pentacyclic terpenoids of two peat deposits of rich fen Kirek located in Western Siberia. Considering the individual n-alkanes concentrations, some indexes were calculated to estimate the humidity during peat formation. It was shown that the pH of peat medium primarily affects steroids, tri- and pentacyclic terpenoids transformations

Juvenile Offenders: Reasons and Characteristics of Criminal Behavior

The article examines the phenomenon of “juvenile delinquency”, assesses its actual state and establishes the tendencies of its manifestations. Juvenile delinquency in Ukraine as a part of crime in a broad sense arises and develops under the influence of certain determinants. The study of the causes and conditions of juvenile delinquency remains relevant today, which indicates the special danger of this kind of crime for the development of society. The purpose of the article is to study the state of the problem in Ukraine and the experience of other countries in minimising the criminal behaviour of minors in the process of property and non-property relations. The leading approach that was used when writing the article is the comparison and analysis of modern materials on the problems of criminal behaviour of criminals who have not reached the age of majority. As a result, it was possible to identify the social characteristics of juvenile criminals and the reasons for their criminal behaviour. Considerable attention is paid to the factors influencing the commission of crimes: a dysfunctional family, shortcomings of the educational process, the problem of alcohol and drug use by minors. In addition, some directions for the prevention of juvenile delinquency were developed. The applied value is the ability to change legislation in terms of work and correction of minor criminals’ behaviour

Synthesis of chiral ferrocenylazines. Negishi cross-coupling or S N H reactions?

Preparation of new hetaryl-containing planar chiral ferrocene by a nucleophilic substitution of hydrogen in azines was performed using a lithium derivative of (S)-ferrocenyl-p-tolylsulfoxide as s nucleophilic reagent © 2013 Pleiades Publishing, Ltd

THERE ARE CELL’S REACTIONS AND REGULATORY MECHANISMS AT THE EXPERIMENTAL ASEPTIC INFLAMMATION

The characteristics of cell's phases experimental aseptic inflammation with indicate levels of interleukin-1β, interleukin-10, corticosterone are presented. The area of aseptic inflammation, have logical relay of cell's populations, IL-1β, IL-10, corticosterone are regulate cell's processes. And by 20 days inflammatory process complete formation dense connective capsule

THE ROLE OF AZOXIMERA BROMIDE IN REGULATORY MECHANISMS OF CELL’S REACTIONS AT THE MICROBIC INFLAMMATION

The regulatory mechanisms of azoximera bromide on the characteristics of cell's phases experimental microbic inflammation with indicate concentrations of interleukin-1β, interleukin-10, corticosterone are presented. The inflammation of staphylococcus is a chronic process, however azoximera bromide shorten time cell's phases of inflammation, activate functions of inflammatory cells, optimizate synthesis of interleukins and corticosterone, preclude from chronization inflammation

Carácter económico de la competencia: enfoques metodológicos generales del problema

In the period of structural and qualitative changes in the Russian economy, the development of the labor market and the educational services market, the effectiveness of economic education is largely determined by the level of formation of economic competencies of students. The development of the diversification process required bringing the education system in line with the requirements of market relations, the principles of alternatives and variability, ensuring the quality of education, which is the most important condition for the specialist’s demand in the labor market. The target component of the model of formation of students’ economic competences by definition includes the goals and objectives of economic training. The increased demand for economic knowledge has led to new forms of economic education. The activity component in the model of formation of economic competencies focuses on the fact that in the domestic system of education in relation to the vocational school there was a long-term practice of compiling the qualification characteristics of a specialist, which fixed the requirements for knowledge, skills and abilities of graduates of various specialties, where in addition to the knowledge paradigm there were the terms “readiness”, “ability”, “responsibility”, “understanding” and “worldview”, expanding the close framework of such a paradigm. The main idea of the activity approach in education is not connected with the activity itself, but with the activity as a means of formation and development of the student’s personality. The content component of the model involves the formation of students’ economic competencies in the form of key, professional and additional economic competencies at different levels of professional education, taking into account training in economic and non-economic specialties.En el período de cambios estructurales y cualitativos en la economía rusa, el desarrollo del mercado laboral y el mercado de servicios educativos, la efectividad de la educación económica está determinada en gran medida por el nivel de formación de competencias económicas de los estudiantes. El desarrollo del proceso de diversificación requirió alinear el sistema educativo con los requisitos de las relaciones de mercado, los principios de alternativas y variabilidad, asegurando la calidad de la educación, que es la condición más importante para la demanda del especialista en el mercado laboral. El componente objetivo del modelo de formación de las competencias económicas de los estudiantes, por definición, incluye las metas y objetivos de la formación económica. La mayor demanda de conocimiento económico ha llevado a nuevas formas de educación económica. El componente de actividad en el modelo de formación de competencias económicas se centra en el hecho de que en el sistema educativo interno en relación con la escuela vocacional había una práctica a largo plazo de recopilar las características de calificación de un especialista, que fijaba los requisitos de conocimiento, habilidades y destrezas de graduados de diversas especialidades, donde además del paradigma del conocimiento existían los términos “preparación”, “habilidad”, “responsabilidad”, “comprensión” y “visión del mundo”, ampliando el marco cercano de tal paradigma. La idea principal del enfoque de la actividad en la educación no está relacionada con la actividad en sí, sino con la actividad como un medio de formación y desarrollo de la personalidad del alumno. El componente de contenido del modelo implica la formación de competencias económicas de los estudiantes en forma de competencias económicas clave, profesionales y adicionales en diferentes niveles de educación profesional, teniendo en cuenta la capacitación en especialidades económicas y no económicas

Geometrical restrictions of water diffusion in aqueous protein systems. A study using NMR field-gradient techniques

Geometrical restrictions of water diffusion in different aqueous protein systems were studied using two versions of the NMR field gradient technique. The samples were aqueous systems of bovine serum albumin, gelatin and horse myoglobin at concentrations ranging from diluted solutions to almost dry powders being only partly hydrated. Hydrated protein aerogels were produced by the aid of a special preparation procedure and studied in addition. The experiments referred to the, temperature and concentration dependences of the water diffusion coefficient above and below the free-water freezing temperature. The diffusion coefficient within clusters of overlapping hydration shells is reduced by one order of magnitude compared with that of bulk water. Geometrical restrictions manifest themselves (a) by the obstruction effect observed at low protein concentrations, (b) by the topologically two-dimensional diffusion in the network of overlapping hydration shells, (c) by the percolation threshold appearing at about 15%b.w. water and (d) by the anomalous diffusion behaviour concluded from the protein aerogel study. © 1993 Springer

Synthesis of PlanarChiral Azinylferrocenes

Two synthetic routes to the chiral azinylferrocenes (CAFs) 6, key intermediates for the synthesis of new enantiomerically enriched P,N-ligands, have been compared. The palladium complexes of P,N-ligands have been used as catalysts for allylic alkylation and amination reactions, which proceeds with high enantioselectivity to give substitution products in good yields

Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study

The recovery period after traumatic brain injury (TBI) is often complicated by secondary damage that may last for days or even months after trauma. Two proteins, Hsp70 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were recently described as modulating post-traumatic processes, and in this study, we test them as targets for combination therapy using an inhibitor of GAPDH aggregation (derivative of hydrocortisone RX624) and an inducer of Hsp70 synthesis (the pyrrolylazine derivative PQ-29). The protective effect of the combination on C6 rat glioblastoma cells treated with the cerebrospinal fluid of traumatized animals resulted in an increase in the cell index and in a reduced level of apoptosis. Using a rat weight drop model of TBI, we found that the combined use of both drugs prevented memory impairment and motor deficits, as well as a reduction of neurons and accumulation of GAPDH aggregates in brain tissue. In conclusion, we developed and tested a new approach to the treatment of TBI based on influencing distinct molecular mechanisms in brain cells. © 2022 by the authors.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2021-683; Russian Science Foundation, RSF: 18-74-10087, 22-13-00298This research was funded by the Russian Science Foundation, research projects #18-74-10087 and #22-13-00298.Rat glioblastoma C6 cells were obtained from the shared research facility “Vertebrate cell culture collection” supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2021-683). Cells were cultured in DMEM/F12 medium (Gibco, Carlsbad, CA, USA) containing 10% fetal bovine serum (FBS; Gibco, Carlsbad, CA, USA), 100 units/mL penicillin, and 0.1 mg/mL streptomycin (BioloT, St. Petersburg, Russia) at 37 °C and 5% CO.