Rimska streljačka oprema nađena na Gardunu kod Trilja

U radu se obrađuje skupina slučajnih nalaza s lokaliteta Gardun izloženih u Muzeju Cetinske Krajine. Svi su nalazi pripadali brojnoj opremi rimskih postrojbi stacioniranih na Gardunu. Nalaze se pokušalo povezati s pojedinim vojnim postrojbama te time približno datirati

Acute promyelocytic leukemia after whole brain irradiation of primary brain lymphomainan HIV-infected patient

The occurrence of acute promyelocytic leukemia (APL) in HIV-infected patients has been reported in only five cases. Due to a very small number of reported HIV/APL patients who have been treated with different therapies with the variable outcome, the prognosis of APL in the setting of the HIV-infection is unclear. Here, we report a case of an HIV-patient who developed APL and upon treatment entered a complete remission. A 25-years old male patient was diagnosed with HIV-infection in 1996, but remained untreated. In 2004, the patient was diagnosed with primary central nervous system lymphoma. We treated the patient with antiretroviral therapy and whole-brain irradiation, resulting in complete remission of the lymphoma. In 2006, prompted by a sudden neutropenia, we carried out a set of diagnostic procedures, revealing APL. Induction therapy consisted of standard treatment with all-trans-retinoic-acid (ATRA) and idarubicin. Subsequent cytological and molecular analysis of bone marrow demonstrated complete hematological and molecular remission. Due to the poor general condition, consolidation treatment with ATRA was given in March and April 2007. The last follow-up 14 months later, showed sustained molecular APL remission. In conclusion, we demonstrated that a complete molecular APL remission in an HIV-patient was achieved by using reduced-intensity treatment

Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease?

BACKGROUND: Pulmonary interstitial glycogenosis (PIG) arises from a developmental disorder of the pulmonary mesenchyme and presents clinically with reversible neonatal respiratory distress and/or persistent pulmonary hypertension of the newborn (PPHN). OBJECTIVE: We report two cases of PIG in patients with congenital heart disease (CHD) and evidence of PPHN. RESULTS: Both cases demonstrated the hallmark PIG histologic finding of diffuse, uniform interstitial thickening due to the presence of immature interstitial cells containing abundant cytoplasmic glycogen. CONCLUSIONS: We report the second and third patients with PIG associated with CHD. Because histologic examination is required to establish the diagnosis, we speculate that PIG, although rare, may be underrecognized in neonates presenting with PPHN in the setting of CHD

Quantitative test of the barrier nucleosome model for statistical positioning of nucleosomes up- and downstream of transcription start sites

The positions of nucleosomes in eukaryotic genomes determine which parts of the DNA sequence are readily accessible for regulatory proteins and which are not. Genome-wide maps of nucleosome positions have revealed a salient pattern around transcription start sites, involving a nucleosome-free region (NFR) flanked by a pronounced periodic pattern in the average nucleosome density. While the periodic pattern clearly reflects well-positioned nucleosomes, the positioning mechanism is less clear. A recent experimental study by Mavrich et al. argued that the pattern observed in S. cerevisiae is qualitatively consistent with a `barrier nucleosome model', in which the oscillatory pattern is created by the statistical positioning mechanism of Kornberg and Stryer. On the other hand, there is clear evidence for intrinsic sequence preferences of nucleosomes, and it is unclear to what extent these sequence preferences affect the observed pattern. To test the barrier nucleosome model, we quantitatively analyze yeast nucleosome positioning data both up- and downstream from NFRs. Our analysis is based on the Tonks model of statistical physics which quantifies the interplay between the excluded-volume interaction of nucleosomes and their positional entropy. We find that although the typical patterns on the two sides of the NFR are different, they are both quantitatively described by the same physical model, with the same parameters, but different boundary conditions. The inferred boundary conditions suggest that the first nucleosome downstream from the NFR (the +1 nucleosome) is typically directly positioned while the first nucleosome upstream is statistically positioned via a nucleosome-repelling DNA region. These boundary conditions, which can be locally encoded into the genome sequence, significantly shape the statistical distribution of nucleosomes over a range of up to ~1000 bp to each side.Comment: includes supporting materia

Patterns and Mechanisms of Ancestral Histone Protein Inheritance in Budding Yeast

Tracking of ancestral histone proteins over multiple generations of genome replication in yeast reveals that old histones move along genes from 3′ toward 5′ over time, and that maternal histones move up to around 400 bp during genomic replication

Prevalencia de enteroparasitosis humanas en un área vulnerable de la provincia de Buenos Aires

El barrio “El Molino”, ubicado en el Municipio de Ensenada, Provincia de Buenos Aires, República Argentina (34° 49′ S, 57° 58′ W), alberga una población precarizada con conductas higiénico-sanitarias inadecuadas para la salud. El equipo de trabajo, integrado por docentes y alumnos de 4 Facultades de la UNLP, desarrolla un proyecto de Extensión Universitaria destinado a contribuir en el diagnóstico y prevención de zoonosis parasitarias, desde el año 2005 ininterrumpidamente. El objetivo del presente estudio es diagnosticar las parasitosis intestinales zoonóticas (de carácter desatendido) en la población de un área de riesgo sanitario y analizar su relación con las costumbres de las familias.Facultad de Ciencias Veterinaria

Prevalencia de enteroparasitosis humanas en un área vulnerable de la provincia de Buenos Aires

El barrio “El Molino”, ubicado en el Municipio de Ensenada, Provincia de Buenos Aires, República Argentina (34° 49′ S, 57° 58′ W), alberga una población precarizada con conductas higiénico-sanitarias inadecuadas para la salud. El equipo de trabajo, integrado por docentes y alumnos de 4 Facultades de la UNLP, desarrolla un proyecto de Extensión Universitaria destinado a contribuir en el diagnóstico y prevención de zoonosis parasitarias, desde el año 2005 ininterrumpidamente. El objetivo del presente estudio es diagnosticar las parasitosis intestinales zoonóticas (de carácter desatendido) en la población de un área de riesgo sanitario y analizar su relación con las costumbres de las familias.Facultad de Ciencias Veterinaria

Prevalencia de enteroparasitosis humanas en un área vulnerable de la provincia de Buenos Aires

El barrio “El Molino”, ubicado en el Municipio de Ensenada, Provincia de Buenos Aires, República Argentina (34° 49′ S, 57° 58′ W), alberga una población precarizada con conductas higiénico-sanitarias inadecuadas para la salud. El equipo de trabajo, integrado por docentes y alumnos de 4 Facultades de la UNLP, desarrolla un proyecto de Extensión Universitaria destinado a contribuir en el diagnóstico y prevención de zoonosis parasitarias, desde el año 2005 ininterrumpidamente. El objetivo del presente estudio es diagnosticar las parasitosis intestinales zoonóticas (de carácter desatendido) en la población de un área de riesgo sanitario y analizar su relación con las costumbres de las familias.Facultad de Ciencias Veterinaria

Prevalencia Dioctophyme renale en un área vulnerable de la provincia de Buenos Aires

Desde el año 2005 a la fecha, de manera ininterrumpida, el grupo de trabajo realiza tareas en un área vulnerable de la Prov. de Bs. As., barrio “El Molino” en la localidad Punta Lara, municipio de Ensenada. El excesivo desmonte y posterior antropización originaron un área suburbana inundable y de elevada vulnerabilidad social y sanitaria, ya que los vecinos vuelcan sus efluentes cloacales sin tratamiento previo. Se estudiaron 692 caninos y 257 personas de la zona, tomando muestras de orina para verificar la presencia de huevos de Dioctophyme renale.Facultad de Ciencias Veterinaria