The impact of ICT on adolescent's perception and consumption of substances

Considerando el potencial de las intervenciones basadas en las tecnología de la información sobre los jóvenes, se realiza una prueba controlada para conocer el impacto de estas tecnologías (Internet y SMS) en las percepciones de los adolescentes respecto al conocimiento y consumo de drogas, así como comportamientos relacionados al mismo. La población objetivo fueron estudiantes de tercero y cuarto de liceo de colegios privados de Montevide

Preventive Antibacterial Therapy in Acute Ischemic Stroke: A Randomized Controlled Trial

BACKGROUND: Pneumonia is a major risk factor of death after acute stroke. In a mouse model, preventive antibacterial therapy with moxifloxacin not only prevents the development of post-stroke infections, it also reduces mortality, and improves neurological outcome significantly. In this study we investigate whether this approach is effective in stroke patients. METHODS: Preventive ANtibacterial THERapy in acute Ischemic Stroke (PANTHERIS) is a randomized, double-blind, placebo-controlled trial in 80 patients with severe, non-lacunar, ischemic stroke (NIHSS>11) in the middle cerebral artery (MCA) territory. Patients received either intravenous moxifloxacin (400 mg daily) or placebo for 5 days starting within 36 hours after stroke onset. Primary endpoint was infection within 11 days. Secondary endpoints included neurological outcome, survival, development of stroke-induced immunodepression, and induction of bacterial resistance. FINDINGS: On intention-to treat analysis (79 patients), the infection rate at day 11 in the moxifloxacin treated group was 15.4% compared to 32.5% in the placebo treated group (p = 0.114). On per protocol analysis (n = 66), moxifloxacin significantly reduced infection rate from 41.9% to 17.1% (p = 0.032). Stroke associated infections were associated with a lower survival rate. In this study, neurological outcome and survival were not significantly influenced by treatment with moxifloxacin. Frequency of fluoroquinolone resistance in both treatment groups did not differ. On logistic regression analysis, treatment arm as well as the interaction between treatment arm and monocytic HLA-DR expression (a marker for immunodepression) at day 1 after stroke onset was independently and highly predictive for post-stroke infections. INTERPRETATION: PANTHERIS suggests that preventive administration of moxifloxacin is superior in reducing infections after severe non-lacunar ischemic stroke compared to placebo. In addition, the results emphasize the pivotal role of immunodepression in developing post-stroke infections. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN74386719

Cultivating Skills for 21st Century Professionals: Development and Assessment of Process Skills in Ecology and Conservation Biology Students

Background/Question/Methods: Understanding and conserving the biosphere increasingly requires proficiency in skills including critical thinking, data analysis, oral communication, broad synthesis of information and teamwork across diverse groups. However, a real concern exists that US undergraduate science students do not currently develop these important process skills needed as professionals. First, our work asks “how can we best ‘operationalize’ teaching of process skills?” Second, we must also discover how to evaluate development of specific process skills in our students. Such assessment allows us to determine if we have succeeded in teaching these skills with a gain or loss in content understanding. Here, we present the design and preliminary results of a recently launched experimental study aimed at these two tasks. The study brings together faculty from diverse institutions and professional conservation biologists to create and validate a set of instructional materials for process skills development. Following development, selected faculty will pilot teaching and assessment materials in diverse classroom settings. Project participants, led by investigators from the American Museum of Natural History’s Center for Biodiversity and Conservation, designed a multi-year research experiment in two stages: (1) development of instructional materials and associated assessment tools for three skills (i.e., critical thinking, oral communication, and data analysis), and (2) application of these materials in the classroom under two different instruction modalities, individual reflection versus intensive classroom discussion of the skill. These two modalities investigate student development of the targeted process skill and how intensity of a teaching intervention influences student success. Results/Conclusions: For each selected skill, faculty participants and consultants developed two exercises that focused on ecology and conservation biology topics, either new or based on the modules produced by the Network of Conservation Educators and Practitioners (NCEP; http://ncep.amnh.org). Participants also created the following assessment tools: student self-assessment questionnaires focusing on their confidence for each skill, content gains assessments, and rubrics for assessing skill performance. These will be applied pre and post application of the instructional materials. Our plans include validation and finalization of materials over summer 2011 and pilots in the classrooms occurring in at least 14 US institutions (including Puerto Rico) beginning in fall 2011. While the study focuses on these skills in the context of ecology and conservation biology, our approach and results should be of direct use for other related, integrative fields such as natural resource management, sustainable development studies, and public health. We welcome faculty input and interest in the project