Challenges and Opportunities for Sustainable Urban Farming in South African Low-Income Settlements: A Case Study in Durban

Growing urban centres have been attracting ever higher numbers of rural migrants, including small-scale farmers, looking for better opportunities due to the rise of large-scale farming, loss of land and climate change. Consequently, there has been an increase in the number of spontaneous and informal settlements being constructed as cities do not keep up with the planning and infrastructure development for new arrivals. Urban dwellers in informal, unplanned settlements where issues of land tenure and access to services are prevalent have, consequently, been exposed to precarious living conditions with limited access to food and water scarcity. Urban agriculture (UA) strategies have been adopted by those residents to alleviate poverty and food insecurity, and have been seen to perform other functions, such as environmental, social, cultural and developmental. This study explores challenges and opportunities for sustainable urban farming as an integrated environmental management strategy for the upgrading of informal settlements in three case studies in Durban. This paper demonstrates the need for municipalities to support community driven processes to ensure sustainability of UA initiatives and sustained investment for maintenance. Policy makers need to create an enabling environment for academics, non-governmental organizations (NGOs) and the private sector to co-develop water efficient solutions to manage the food-water nexus and capitalise on localised community structures and groups, such as co-operatives and women groups.</jats:p

The potential of performance targets (imihigo) as drivers of energy planning and extending access to off‐grid energy in rural Rwanda

Rwanda has one of the lowest electrification rates in Sub‐Saharan Africa and ambitious targets of boosting energy access, with an encouraged private sector involvement. However, barriers such as end‐user awareness and participation in policy and business model design prohibit the pace of rural electrification. A case of Rwanda is analyzed, pointing to the potential of the imihigo (performance contracts) framework. Given the adoption of household‐level performance contracts, which can include energy access, it is proposed they could drive local participation among off‐grid communities. Results of a survey with 218 users of Solar Home Systems in North‐Western Rwanda and from five focus groups show that village‐level energy targets impact on the prioritization of energy target setting among households. Including off‐grid energy options in the imihigo booklets distributed to households could influence awareness raising and allow private sector providers to act in a more targeted way, prioritizing areas with most prevalent energy targets. Additionally, community meetings (umuganda) tied to imihigo offer participatory spaces for information and feedback sharing. These will assist in the design of energy planning and business models, which best fit local needs and respond to the challenges faced by the energy poor

Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis

Species-specific antimicrobial therapy has the potential to combat the increasing threat of antibiotic resistance and alteration of the human microbiome. We therefore set out to demonstrate the beginning of a pathogen-selective drug discovery method using the periodontal pathogen Porphyromonas gingivalis as a model. Through our knowledge of metabolic networks and essential genes we identified a “druggable” essential target, meso-diaminopimelate dehydrogenase, which is found in a limited number of species. We adopted a high-throughput virtual screen method on the ZINC chemical library to select a group of potential small-molecule inhibitors. Meso-diaminopimelate dehydrogenase from P. gingivaliswas first expressed and purified in Escherichia coli then characterized for enzymatic inhibitor screening studies. Several inhibitors with similar structural scaffolds containing a sulfonamide core and aromatic substituents showed dose-dependent inhibition. These compounds were further assayed showing reasonable whole-cell activity and the inhibition mechanism was determined. We conclude that the establishment of this target and screening strategy provides a model for the future development of new antimicrobials

Barriers and opportunities for participatory environmental upgrading: Case study of Havelock informal settlement, Durban

Urbanisation is one of the key challenges of this decade with 68% of the global population likely to be living in urban areas by 2050. This challenge is particularly acute in sub-Saharan Africa where future towns and cities will see an influx of residents living in spontaneous human settlements. As cities struggle to keep up with the speed of growth and spread of informal settlements, associated environmental challenges such as air and water pollution and waste management have been significantly increasing posing a health risk in high density settings. Using the case of Havelock informal settlement in Durban, the authors identified key challenges associated with poor environmental conditions, lack of basic infrastructure, and the implications for settlement upgrading. The study uses mixed methods combining transect walks, priority mapping, seasonal calendar, focus group discussions and household interviews to explore the households' most challenging environmental issues faced daily by informal dwellers. This paper seeks to make the case for targeted participatory environmental infrastructure and management delivery in urban settlements in South Africa. The research also highlights the value of adopting a holistic approach to infrastructure provision to effectively enhance the living conditions of communities. Targeted participatory processes are vital to ensure that holistic infrastructure interventions are acceptable, appropriate and embedded in local communities to create sustainable habitats

The impact of power outages on households in Zambia

As global average temperatures rise, so does the frequency and intensity of El Niño-induced droughts, which in turn threaten the reliability of hydropower. 1.4 billion people live in countries where hydropower constitutes more than a quarter of the electricity production and which have experienced El Niño droughts, meaning many more power outages can be expected around the world. Little research has been conducted on the impact of power outages on mental health. This study takes Zambia as its case study to examine the impact that El Niño droughts have had on the lives of householders connected to a highly hydropower-dependant electricity grid, and includes the impact it has had on their physical and self-reported mental health. Using 54 online responses to a survey, we found that the greatest impacts of outages spoiled food, compromised entertainment, compromised ability to work and limitation in cooking options. More than a fifth of respondents reported experiencing self-reported depression to a major degree or all of the time due to power outages, with individuals writing their own responses that they felt debilitated, experienced reduced communication and reduced activities, and stress. Using Bayesian inference, we found that changes in sleeping patterns arising from power outages was a statistically significant predictor of self-reported depression. 63% of surveyed households were willing to pay approximately USD 0.10/kWh as of the end of 2019, about double the tariff that they did, to ensure reliable electricity supply. Household income was a statistically significant predictor of willingness to pay more

Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes

Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth with ~ 40% of preterm births being associated with PPROM and occurs in 1% - 2% of all pregnancies. We hypothesized that multiple rare variants in fetal genes involved in extracellular matrix synthesis would associate with PPROM, based on the assumption that impaired elaboration of matrix proteins would reduce fetal membrane tensile strength, predisposing to unscheduled rupture. We performed whole exome sequencing (WES) on neonatal DNA derived from pregnancies complicated by PPROM (49 cases) and healthy term deliveries (20 controls) to identify candidate mutations/variants. Genotyping for selected variants from the WES study was carried out on an additional 188 PPROM cases and 175 controls. All mothers were self-reported African Americans, and a panel of ancestry informative markers was used to control for genetic ancestry in all genetic association tests. In support of the primary hypothesis, a statistically significant genetic burden (all samples combined, SKAT-O p-value = 0.0225) of damaging/potentially damaging rare variants was identified in the genes of interest—fibrillar collagen genes, which contribute to fetal membrane strength and integrity. These findings suggest that the fetal contribution to PPROM is polygenic, and driven by an increased burden of rare variants that may also contribute to the disparities in rates of preterm birth among African Americans

Integrating psychosocial and WASH school interventions to build disaster resilience

This paper reviews the key disaster risk management (DRM) frameworks used for protecting children's wellbeing in disaster settings and identifies a lack of consideration for (1) psychosocial and (2) water, sanitation and hygiene (WASH) needs. It also demonstrates that these two domains are meaningfully linked, as access to adequate WASH provision may protect psychosocial wellbeing and promote community resilience. As support in both domains is vitally important to children's wellbeing, these gaps warrant immediate attention. Schools are uniquely situated to support these needs as part of disaster risk management and resilience building. Therefore, we consider the ASEAN Common Framework for Comprehensive School Safety (ACFCSS), which is an adaptation of the Comprehensive School Safety Framework (CSS) implemented in schools across the ASEAN region. While the CSS explicitly considers WASH, it only briefly considers psychosocial support; the ACFCCS lacks consideration of both domains. We argue revisions of the ACFCSS should prioritise the inclusion of psychosocial and WASH support and consider the role of schools beyond their capacity as educational institutions. We present an adaptation of ACFCSS with an additional framework pillar to guide this revision. Overall, we advocate for an integrated approach to DRM in schools based on an evidence-based, interdisciplinary perspective. We provide a series of evidence-based recommendations for DRM frameworks to consider, especially for those that intend to safeguard the wellbeing of children

GaN evaporation and enhanced diffusion of Ar during high-temperature ion implantation

GaN films were implanted with 150 keV Ar+ at temperatures up to 1100 °C to a dose of 3×1015 cm-2. Concentration profiles of Ar were measured by secondary ion mass spectroscopy and depth distributions of ion-induced damage were estimated from Rutherford backscattering/channeling spectra. No redistribution of Ar atoms was detected up to 700 °C. At 1000 °C a deep penetrating diffusion tail and a shift of the Ar peak to the surface were observed. At temperatures higher than 800 °C shift of the damage peak to the surface was also observed. We attributed the shift of the Ar peak and the damage peaks to evaporation of thin layer of GaN during high-temperature implantation and estimated its temperature dependence