Notes on Dolichopodidae (Diptera) from the White Sea coast and islands (Russian North)

Original data on Dolichopodidae from the Belomorsk district of Karelia and Bolshoi Solovetskii Island (Arkhangelsk Region, Primorskii district) resulted from the short-term visit (2018) are presented. All ten collected species and the genus Medetera are firstly recorded for the Solovetskiye Islands. Dolichopus discifer Stannius, 1831, Dolichopus ungulatus (Linnaeus, 1758), Rhaphium laticorne (Fallén, 1823), Sympycnus pulicarius (Fallén) and Syntormon tarsatus (Fallén, 1823) are new species for the Arkhangelsk Region. Photographs of habitats of dolichopodid species are included

Extended LTA, TNF, LST1 and HLA Gene Haplotypes and Their Association with Rubella Vaccine-Induced Immunity

Recent studies have suggested the importance of HLA genes in determining immune responses following rubella vaccine. The telomeric class III region of the HLA complex harbors several genes, including lymphotoxin alpha (LTA), tumor necrosis factor (TNF) and leukocyte specific transcript -1 (LST1) genes, located between the class I B and class II DRB1 loci. Apart from HLA, little is known about the effect of this extended genetic region on HLA haplotypic backgrounds as applied to immune responses.We examined the association between immune responses and extended class I-class II-class III haplotypes among 714 healthy children after two doses of rubella vaccination. These extended haplotypes were then compared to the HLA-only haplotypes. The most significant association was observed between haplotypes extending across the HLA class I region, ten-SNP haplotypes, and the HLA class II region (i.e. A-C-B-LTA-TNF-LST1-DRB1-DQA1-DQB1-DPA1-DPB1) and rubella-specific antibodies (global p-value of 0.03). Associations were found between both extended A*02-C*03-B*15-AAAACGGGGC-DRB1*04-DQA1*03-DQB1*03-DPA1*01-DPB1*04 (p = 0.002) and HLA-only A*02-C*03-B*15-DRB1*04-DQA1*03-DQB1*03-DPA1*01-DPB1*04 haplotypes (p = 0.009) and higher levels of rubella antibodies. The class II HLA-only haplotype DRB1*13-DQA1*01-DQB1*06-DPA1*01-DPB1*04 (p = 0.04) lacking LTA-TNF-LST1 SNPs was associated with lower rubella antibody responses. Similarly, the class I-class II HLA-only A*01-C*07-B*08-DRB1*03-DQA1*05-DQB1*02-DPA1*01-DPB1*04 haplotype was associated with increased TNF-alpha secretion levels (p = 0.009). In contrast, the extended AAAACGGGGC-DRB1*01-DQA1*01-DQB1*05-DPA1*01-DPB1*04 (p = 0.01) haplotype was found to trend with decreased rubella-specific IL-6 secretion levels.These data suggest the importance of examining both HLA genes and genes in the class III region as part of the extended haplotypes useful in understanding genomic drivers regulating immune responses to rubella vaccine

Lipid profile indices in young people with different types of diabetes mellitus

Of all types of diabetes mellitus (DM), type 1 diabetes mellitus (DM1) and type 2 diabetes (DM2) are most often diagnosed in young people. However, up to 10 % of all cases of DM diagnosed at a young age are monogenic forms of DM – MODY (Maturity-Onset Diabetes of the Young), the most common forms of which are MODY2 (GCK-MODY) and MODY3 (HNF1AMODY). These genetic forms of DM are poorly understood, so the investigation of their clinical and biochemical parameters, including lipid profile, and comparison with more studied forms of DM is of high importance. The aim of this study was to analyze the characteristics of the lipid profile in patients aged 18–45 years with DM1, DM2, GCK-MODY and HNF1A-MODY. Material and methods. In 56 patients diagnosed by the molecular genetic method MODY, as well as in 82 patients with DM2 and 14 patients with DM1, matched by sex, age, a lipid profile was studied. Results. There were no statistically significant differences in total cholesterol and low-density lipoprotein cholesterol between young patients with different types of DM. In HNF1a-MODY, the highest level of triglycerides was revealed; in DM1, the level of high-density lipoprotein cholesterol was significantly higher than in other types of DM. Among the changes in the lipid profile among all types of DM, hypercholesterolemia was more often determined

THE ROLE OF THE STUDY OF NATIONAL CULTURE AND TRADITION IN THE AESTHETIC EDUCATION OF MODERN DESIGNERS

В статье представлена связь изобразительного, декоративно-прикладного и народного искусства в целях художественного образования и эстетического воспитания студентов на народных традицияхThe article presents the connection of fine, decorative, applied and folk art for the purpose of art education and aesthetic education of students on folk tradition

THE USE OF ANTI-INFLAMMATORY EFFECT OF THE SORPTION COMPLEX IN REHABILITATION OF PATIENTS WITH CHRONIC HEART FAILURE AFTER MYOCARDIAL INFARCTION

The aim of the study was to investigate the anti-inflammatory effect of minimum dosages of enterosorbent containing carbon and aluminum oxide on the background of standard treatment for patients with chronic heart failure after myocardial infarction. After two weeks of receiving enterosorbent containing carbon and aluminum oxide in patients with CHF (n = 39) showed a reduction in the level of C-reactive protein, as well as marked improvement in microcirculation, which is a manifestation reduce systemic inflammation characteristic of chronic heart failure

International Legal Standards in Crime Prevention

A qualitatively new stage in the development of international and national criminal law was marked by the international standards created to combat crime and the treatment of offenders by the global community, which deepens their interaction and establishes conditions for crime prevention and the protection of human rights. The purpose of the academic paper is to identify the primary crime prevention standards, their initiators and disseminators, the principal standardization areas, and approaches to address the issue. The research aims to show modern international norms and standards based on investigating the UN declarations and other normative documents formed by international organizations considering their development prospects. The need for more scientific, legal literature on modern standardization in crime prevention determines the research relevance. Therefore, this research is based on the last three UN Congresses in world crime prevention. The results show systematized information and the standardization of crime prevention. The study reviews the primary standards in the criminal treatment and detainee juvenile offenders and methods of combating modern problems in the information space, human trafficking, and terrorism. Emphasis is also placed on gender policy, corruption, and other contemporary issues. The research shows that the UN holds the Congresses according to the social development and crimes variety once in five years. The relevant problems of the modern world are computer technology crimes, crime in COVID-19, and corruption

GCK-MODY diabetes course in persons over 18 years of age: prospective observation

Most young patients with hyperglycemia have type 1 diabetes and type 2 diabetes but up to 10% of all cases of the disease occur in MODY (Maturity Onset Diabetes of the Young). Published abstracts show features of the debut, laboratory and genetic characteristics of MODY in the Russian population. However there is a small amount of data on the clinical course of this nosology in the Russian Federation.Aim: To investigate the characteristics of the 3-year course of GCK-MODY diagnosed after 18 years.Materials and methods: 85 probands and 46 relatives of the first and second degrees of kinship with a clinical diagnosis of GCK-MODY were examined: biochemical and hormonal blood tests, ultrasound, molecular genetic studies. Patients were invited for a follow-up visit 3 years after verification of the pathogenic mutations associated with GCK-MODY. Examination, biochemical and hormonalanalyzes , ultrasound were done in second visit.Results: The diagnosis GCK-MODY was verified by a molecular genetic study in 25 probands (29.4%). In 33 of 46 (71.7%) relatives of patients with GCK-MODY were diagnosed identical mutations. In 31 patients with GCK-MODY diagnosed after 18 years, a dynamic observation was performed for three years. Most patients over 18 years of age did not have clinical manifestations of carbohydrate metabolism disorders when diagnosing GCK-MODY and follow up visit. Skin rashes and allergic reactions prevailed among concomitant pathologies. Patients with GCK-MODY had preserved β-cell secretion, HbA1c targets were achieved. Low fasting hyperglycemia prevailed which persisted even after treatment correction. Among the characteristics of carbohydrate metabolism, biochemical, lipid and hormonal parameters during GCK-MODY verification and after three years of observation no significant differences were obtained, which indicates a stable course of the disease. Half of the patients achieved normoglycemia by rational nutrition, two people with GCK-MODY within three years after determining the diagnosis were transferred from insulin therapy to oral glucose-lowering drugs. Among oral glucose-lowering drugs prior to GCK-MODY verification most patients used metformin, 3 years later — dipeptidyl peptidase-4 inhibitors.Conclusion. The results of a three-year follow-up of a group of patients with GCK-MODY demonstrate a non-progressive course of this type of diabetes with stable indicators of carbohydrate metabolism and low fasting hyperglycemia that persists after 3 years of observation. With the verification of GCK-MODY and the achievement of the target values of glycated hemoglobin and postprandial glycaemia by rational nutrition, even if a low level of fasting hyperglycemia is determined, the prescription of oral glucose-lowering drugs is not indicated in most cases

The Control Actions Structure Optimization in the Process of the Regions Housing and Communal Services Development

The purpose of the present research is to find areas of organizational and economic mechanisms that enhance the efficiency of regional utilities. A systematic approach to the analysis of the organizational and economic mechanism of Housing in the region, provides a systematic, comprehensive and effective investigation. Strategic Imperatives in the management of regional utilities are defined taking into account the crisis tendencies in the process of its development. Case utilities management is seen as the realization of the objectives of its development in different scenario conditions. With the help of mathematical modeling methods and parameters are determined by the structure of the control actions. The article proposes a methodology for calculating the article options strategy utilities management in the region, the results of modeling the trajectory of housing and communal services of the Republic of Adygea. Keywords: housing and communal services of the region, organizational and economic mechanism, management system, the trajectory of the development process JEL Classifications: L51; O18; R5

Effect of Solid Dispersions on the Dissolution of Ampicillin

© 2016, Springer Science+Business Media New York.In this work, we studied water solubility of ampicillin trihydrate and its solid dispersions (SD) with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin. It was found that SD formation increases the solubility by a factor of 1.34–1.73 and the rate of ampicillin dissolution by a factor of 3.43–7.40. The results of complex physicochemical studies suggest that the improved release of ampicillin from SD is due to its micronization and solubilization by the polymer