Computer-aided decision making for regional seismic risk mitigation accounting for limited economic resources

Seismic risk mitigation levels for an existing building are a balance between the reduction of risk and the cost of rehabilitation. Evidently, the more that is paid the more risk is reduced; however, due to limited public budgets a practical approach is needed to manage the risk reduction program when a portfolio of buildings is concerned. Basically, decision makers face a challenge when there are a large number of vulnerable buildings and there is no plan for how to allocate the appointed budget. This study develops a technological platform that implements a decision-making procedure to establish how to optimally distribute the budget in order to achieve the maximum possible portfolio risk reduction. Decisions are made based on various presumed intervention strategies dependent on building’s level of risk. The technological platform provides an interactive, user-friendly tool, available online, that supports stakeholders and decision makers in understanding what the best economic resource allocation will be after selecting the available budget for a specific portfolio of buildings. In addition, the ease of use enables the user to analyze the extent of risk reduction achievable for different budget levels. Therefore, the web platform represents a powerful tool to accomplish two challenging tasks, namely optimal budget selection and optimal budget allocation to gain territorial seismic risk mitigation

sex differences in axial and limb distribution of melanocytic naevi

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The role of endothelium in covid-19

The 2019 novel coronavirus, known as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19), is causing a global pandemic. The virus primarily affects the upper and lower respiratory tracts and raises the risk of a variety of non-pulmonary consequences, the most severe and possibly fatal of which are cardiovascular problems. Data show that almost one-third of the patients with a moderate or severe form of COVID-19 had preexisting cardiovascular comorbidities such as diabetes mellitus, obesity, hypertension, heart failure, or coronary artery disease. SARS-CoV2 causes hyper inflammation, hypoxia, apoptosis, and a renin–angiotensin system imbalance in a variety of cell types, primarily endothelial cells. Profound endothelial dysfunction associated with COVID-19 can be the cause of impaired organ perfusion that may generate acute myocardial injury, renal failure, and a procoagulant state resulting in thromboembolic events. We discuss the most recent results on the involvement of endothelial dysfunction in the pathogenesis of COVID-19 in patients with cardiometabolic diseases in this review. We also provide insights on treatments that may reduce the severity of this viral infection

Neurobiology of performance anxiety:A new approach

The aim of this study is to investigate the neurobiology of stress/emotionality, creating a multidisciplinary assessment model, which can help to provide psychological and physiological responses depending on the genetic background related to sport performances, social closeness and performance anxiety management in team sports. We enrolled 20 female volleyball players aged 13 \ub1 1 years old played in two different teams during a regional championship final. Saliva collection was carried out before and after the match. In order to evaluate the neuroendocrine effectors involved in stress and performance, we analyzed cortisol and progesterone levels through Elisa standard kit as well as HSP70 and amylase activity as stress-induced markers. As concern the psychometric assesment, we administrated he CSAI-2 test, Closeness Generating Procedure and STAI test. Genomic DNA was isolated from saliva cells using a QIAamp saliva kit according to the manufacturer\u2019s protocols. The SNP of the 5-HTTLPR, BDNF, DRD4 were analyzed. The results of the T-test performed on the total results showed a statistically significant relationship (p < 0.05) in cortisol levels pre and post match, as well between amylase and HP70 according to the genetic background. The analysis performed using just post match samples show a negative correlation between social closeness, cortisol and progesterone levels, with p < 0.010 for progesterone vs social closeness and p < 0.012 for cortisol vs social closeness. About the winner teams and the looser teams, there is a negative correlation between pre match cortisol levels and performance anxiety (p < 0.042)

Transsphenoidal surgery for pituitary adenomas: early results from a single center

To evaluate early results of transsphenoidal surgery for pituitary adenomas

Moringa oleifera leaf powder as functional additive in cookies to protect sh-sy5y cells

The aim of this work is the evaluation of the addition of Moringa leaf powder (MLP) in cookies in terms of antioxidant properties, dough processability and sensorial properties of the cookies. The total content of biophenols and flavonoids in MLP was detected and the identification of the bioactive molecules was performed by HPLC-ESI-TOF-MS measurements, before and after oven treatment at 180◦C for 20 min. After a preliminary evaluation of the MLP water soluble fraction (MLPsf) cytotoxicity, its protective effect against an oxidative injury induced in the SH-SY5Y cells was assessed. Data evidence that the bioactive molecules present in MLPsf are effective in preventing ROS production and in protecting neuronal cells against oxidative stress. Prototypes of cookies containing MLP in different concentrations were then produced and evaluated by a consumer panel. Selected doughs containing MLP were analysed to determine the total content of biophenols in the cookies after baking and their enrichment in terms of valuable chemical elements. The influence of MLP on the viscoelastic behaviour and morphology of the doughs was also assessed. Finally, the potential role in counteracting the insurgence of not treatable neurodegenerative pathologies of two main MLP components, glucomoringin and kaempferol derivatives, present also after the thermal treatment, was discussed

Valutazione dell'efficacia di un programma di attivit\ue0 fisica adattata (APA) in una popolazione di anziani istituzionalizzati affetti da ritardo mentale

Questo studio evidenzia che in questi soggetti l'esercizio fisico continuativo \ue8 risultato essere un elemento fondamentale per garantire benessere psico fisco nall'anziano istituzionalizzato. La performance fisica (WT6' e TUG) e la mobilit\ue0 del cingolo scapolo omerale sono migliorate in modo significativo

Adverse effects of immunotherapies for multiple sclerosis: A network meta-analysis

This is the protocol for a review and there is no abstract. The objectives are as follows: To compare adverse effects of immunotherapies for people with multiple sclerosis (MS) or clinically isolated syndrome (CIS), and to rank these treatments according to their relative risks of adverse effects