CRH receptors in human reproduction

Background: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system. Objective: Herein, the role of CRH receptors in the female reproductive system is presented. Results: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitary-ovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition. Conclusion: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as pre-eclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery. © 2018 Bentham Science Publishers

The expression of nrip1 and lcor in endometrioid endometrial cancer

Background: The aim of the study was to analyze the expression of nuclear receptor interacting protein 1 (NRIP1) and its partner ligand-dependent nuclear receptor co-repressor (LCOR) in endometrioid endometrial cancer and to investigate their association with estrogen receptor (ER), progesterone receptor (PR), Ki-67, clinicopathological parameters and patient survival. Materials and Methods: Immunohistochemical evaluation was carried out to investigate the subcellular expression of NRIP1 and LCOR in endometrioid endometrial cancer samples. Statistical analysis was used to identify the correlations of NRIP1 and LCOR expression with clinicopathological variables and to estimate the survival rates. Results: Endometrial cancer tissues exhibited higher expression of NRIP1 and LCOR in comparison with the normal tissues. Cytoplasmic LCOR expression was positively associated with ER and PR expression, while cytoplasmic NRIP1 expression was positively associated with ER expression. Moreover, cytoplasmic expression of NRIP1 was positively associated with Ki-67. Conclusion: Our study demonstrated that high cytoplasmic expression of LCOR may predict a longer overall survival of patients with endometrioid endometrial cancer. Patients with tumors expressing low levels of LCOR showed a worse survival compared to those expressing high levels. © 2021 International Institute of Anticancer Research. All rights reserved

Feasibility Study of a Variant Procedure of Radical Breast Ductectomy (Dolichectomy) with a Perinipple Incision [Fezabilitatea exciziei ductale radicale prin incizie perimamelonară]

Papillomatosis and recurrent duct ectasia could be treated with terminal lactiferous ducts excision. In this study we describe a modified miniinvasive procedure of terminal lactiferous ducts excision with a perinipple approach to the lower or upper half of the nipple. This technique avoids the much more extensive periareolar incision and has excellent aesthetic results. Copyright© Celsius

Immunohistochemical study of the angiogenetic network of VEGF, HIF1α, VEGFR-2 and endothelial nitric oxide synthase (eNOS) in human breast cancer

Background: The role of Nitric Oxide (NO) in angiogenesis has not been fully clarified yet. A dual role for NO, either inductive or inhibitory, has been proposed on the basis of different effects that high or low concentrations of NO may exert on the angiogenic process. Additionally, it has been referred that NO may induce VEGF production, while VEGF may induce NO production via up-regulation of the endothelial nitric oxide synthase (eNOS), the two pathways being reverse. The aim of the current study was to investigate the expression of key molecules involved in these opposite pathways in primary breast cancer. Methods: Representative tumor samples from 242 patients with early-stage breast cancer (invasive ductal breast carcinomas) were investigated for the expression of VEGF, VEGFR-2, HIF1α, iNOS, and eNOS using immunohistochemistry. Results: Endothelial NOS was found in 159 cases, VEGF in 131 cases, HIF-1α in 139 cases, VEGFR2 in 185 cases and inducible NOS (iNOS) in 22 cases. There was a significant correlation between the expression of VEGF and VEGFR-2, eNOS and VEGF, eNOS and VEGFR-2, eNOS and HIF1α. No statistically significant correlation was found between iNOS and the rest of the studied molecules. Conclusions: In breast cancer cases, the major molecules regulating NO and VEGF production can be co-expressed in the individual carcinomas implying a possibility for the relevant pathways to be active; however appropriate functional experiments remain to be conducted to prove such a hypothesis © 2011 Arányi Lajos Foundation

Management of locally advanced breast cancer of the inferior quadrants after neoadjuvant chemotherapy with "B.E.B.A. omelette" Zervoudis oncoplastic technique

<p><i>We present<strong> </strong>a new technique of oncoplastic surgery for very large tumors of the inferior quadrants of the breast that, after neoadjuvant chemotherapy, allows a good cosmetic result with oncologic safety. This "B.E.B.A. omelette" Zervoudis  technique is a mixture of oncoplastic surgery techniques resulting in large excision of breast tissue with a relatively small scar and no complications. More cases could confirm its value in the palette of the oncoplastic methods for large tumors of the inferior quadrants of the breast.</i></p&gt