Study of OH• Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia

The human body is constantly under attack from free radicals that occur as part of normal cell metabolism, and by exposure to environmental factors such as UV light, cigarette smoke, environmental pollutants and gamma radiation. The resulting “Reactive Oxygen Species” (ROS) circulate freely in the body with access to all organs and tissues, which can have serious repercussions throughout the body. The body possesses a number of mechanisms both to control the production of ROS and to cope with free radicals in order to limit or repair damage to tissues. Overproduction of ROS or insufficient defense mechanisms leads to a dangerous disbalance in the organism. Thereby several pathomechanisms implicated in over 100 human diseases, e.g., cardiovascular disease, cancer, diabetes mellitus, physiological disease, aging, etc., can be induced. Thus, a detailed investigation on the quantity of oxygen radicals, such as hydroxyl radicals (OH•) in human serum blood, and its possible correlation with antioxidant therapy effects, is highly topical. The subject of this study was the influence of schizophrenia on the amount of OH• in human serum blood. The radicals were detected by fluorimetry, using terephthalic acid as a chemical trap. For all experiments the serum blood of healthy people was used as a control group

Визуализация моделирования гиперпространственно-распределенных гибких компьютерно-интегрированных производственных систем

В роботі запропоновано новий концептуальний підхід до створення автоматизованих робочих місць дослідника складних дискретно-подійних систем, який базується на синхронізованій візуалізації спостережень за подіями в системі через анімаційне подання функціонування об’єкта досліджень і графічне відображення кількісно-якісних характеристик в процесі верифікації, проектування та моделювання.The new conceptual approach to the research worker automation work place design is considered. This approach is based on the synchronized visualization of complex system events by functional animation of the research object and graphical representation of it quantity-qualitative assessment.В работе предложено новый концептуальный подход к созданию автоматизированных рабочих мест исследователя сложных дискретно-событийных систем, который базируется на синхронизированной визуализации наблюдений за событиями в системе через анимационное представление функционирования объекта исследований и графическое отображение количественно-качественных характеристик в процессе верификации, проектирования и моделирования

The Fukushima Daiichi Accident

The Fukushima Daiichi Accident consists of a Report by the IAEA Director General and five technical volumes. It is the result of an extensive international collaborative effort involving five working groups with about 180 experts from 42 Member States with and without nuclear power programmes and several international bodies. It provides a description of the accident and its causes, evolution and consequences, based on the evaluation of data and information from a large number of sources available at the time of writing. The set contains six printed parts and five supplementary CD-ROMs. Contents: Report by the Director General; Technical Volume 1/5, Description and Context of the Accident; Technical Volume 2/5, Safety Assessment; Technical Volume 3/5, Emergency Preparedness and Response; Technical Volume 4/5, Radiological Consequences; Technical Volume 5/5, Post-accident Recovery; Annexes. The JRC contributed to volumes 1,2 and 3, which are attached.JRC.F.5-Nuclear Reactor Safety Assessmen

Pressure Fluctuations in Nonideal Plasma

Fluctuations of pressure of singly ionized nonideal plasma are studied using the fluctuation approach which provides the self-consistent joint description of free and weakly bound electron states. The classical molecular dynamics method is used. The electron-ion interaction is described by the density- and temperature-independent cutoff Coulomb potential. The results for partially ionized plasma are related to the Gryaznov-losilevsky effective repulsion which could suppress the thermodynamic plasma instability. The fully ionized plasma region is found where pressure fluctuation distribution can be approximated by the superposition of two Gauss distribution functions. It could be considered as a precursor of the plasma phase transition. (C) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei

2D NMR barcoding and differential analysis of complex mixtures for chemical identification: The Actaea triterpenes

The interpretation of NMR spectroscopic information for structure elucidation involves decoding of complex resonance patterns that contain valuable molecular information (\u3b4 and J), which is not readily accessible otherwise. We introduce a new concept of 2D-NMR barcoding that uses clusters of fingerprint signals and their spatial relationships in the \u3b4-\u3b4 coordinate space to facilitate the chemical identification of complex mixtures. Similar to widely used general barcoding technology, the structural information of individual compounds is encoded as a specifics pattern of their C,H correlation signals. Software-based recognition of these patterns enables the structural identification of the compounds and their discrimination in mixtures. Using the triterpenes from various Actaea (syn. Cimicifuga) species as a test case, heteronuclear multiple-bond correlation (HMBC) barcodes were generated on the basis of their structural subtypes from a statistical investigation of their \u3b4H and \u3b4C data in the literature. These reference barcodes allowed in silico identification of known triterpenes in enriched fractions obtained from an extract of A. racemosa (black cohosh). After dereplication, a differential analysis of heteronuclear single-quantum correlation (HSQC) spectra even allowed for the discovery of a new triterpene. The 2D barcoding concept has potential application in a natural product discovery project, allowing for the rapid dereplication of known compounds and as a tool in the search for structural novelty within compound classes with established barcodes. \ua9 2014 American Chemical Society.Peer reviewed: YesNRC publication: Ye