Russian version of cultural federalism

This article proposes a vision of the idea of “cultural federalism” contributing to the stability of ethnic culture in the era of assimilation by mass culture and global unification, revitalizing the meanings of modernity, enriching the multinational synergy of Russian culture, overcoming capitalist alienation and disintegration of multiculturalism. Methods of analysis and comparison are used in ethnocultural dynamics, mastering such symbolic conquests as “federalism” in the paradigm of modernity, which fits into the process of ethnocultural modernization. The novelty of the work lies in the substantiation of the concept of cultural federalism vs ethnic federalism, as the most appropriate for the modern cultural situation in Russia, the cultural capital of which is multinational and, accordingly, the effect of “Russian multiculturalism” that can oppose secession with an integration trend, reanimate the cooperative effect of the interaction of cultural programs, their complementarity. The authors are interested in the dialectical self-development of historical and cultural differences of the subjects of the federation entering the era of natural modernization, reflected in the ethnic cultural renaissance of the present. The idea of cultural federalism contributes to the development of the Russian national idea, the absence of which reduces the effect of national consolidation and socio-economic development. It is proposed as a tool for solving the problem of "sleeping federalism" and the dialectical contradiction between the form and content of the present state of ethnic federalism

SOCIAL INTERACTION OF LARGE BUSINESSES AS A SECURITY CONDITION OF ITS OPERATION AND DEVELOPMENT IN THE NORTHERN REGION

Purpose: The aim of the research is to identify social interaction of large businesses as a security condition of its operation and development in the northern region. Methodology: This is descriptive-analytic research whose data are obtained through library studies and analytical resources. Data analysis is based on content analysis and analytical comparison. Result: Results showed that to improve the safety of large businesses in the Northern region continuous socially-oriented activities aimed at improving the quality of life of the population of the region of presence with the support of various social initiatives in the region of presence are required. Applications: This research can be used for businessmen and developers. Novelty/Originality: In this research, the model of social interaction of large businesses is presented in a comprehensive and complete manner

The sphericity of erythrocytes and its communication with biochemical, hemostasis and rheological by properties of blood at the patients with coronary disease and arterial hypertension

The aim of the work was to study the peculiarities of the influence of bloodfactors on the development of spherocytosis in patients with coronary disease and arterial hypertension. The study involved 30 patients with coronary disease and 24 patients arterial hypertension with the study of their clinical status and biochemical parameters of blood, hemostasis, blood cell analysis. It was found that the increase in the pool spherocytic cells in patients with arterial hypertension were associated with increased nitric oxide production, while in patients with coronary disease spherocytosis was due to an increase in the concentration of reactive oxygen metabolites

SOME ASPECTS OF THE ESTIMATION OF STRUCTURAL-FUNCTIONAL CHANGES IN MEMBRANE OF ERYTHROCYTES AT THE CARDIOVASCULAR PATHOLOGY

The article presents the estimation of structural-functional changes in erythrocytic membranes accompanied with the change of activity of different enzymes that determine normal functioning of erythrocytes. Change of lipid-protein and protein-protein interactions causes the reapportionment of charges on the surface of erythrocytes and. the decrease of total charge of cell and. leads to the increase of aggregation of erythrocytes and. the change of rheological properties of blood. In the end. it reflects on the effectiveness of oxygen transportation, transcapillary diffusion and perfusion of blood in microcirculation channel

Dysfunction of vascular endothelium at arterial hypertension and coronary disease (literature review)

This review presents the observation of the role of endothelial dysfunction in development of atherosclerosis, coronary disease and. hypertension. Among other causes of endothelial dysfunction the most significant are hemodynamic factors (wall transverse strain, transmural pressure), dyslipoproteinemia, hyperhomocysteinemia, hyperglycemia, free radical damage of endothelium. It is supposed that in development and. progressing of coronary disease more significant role may belong to endothelial dysfunction rather than to morphological vascular changes, predetermined by atherosclerosis. However, there is still no clear view of development of endothelial dysfunction and. mechanisms of development and. progressing of both isolated forms of coronary disease and arterial hypertension and their combination

PROTEINS OF THE ERYTHROCYTE MEMBRANE AND METABOLIC SYNDROME

There is no literature data on the changes of structural and functional qualities of the erythrocyte membrane at the arterial hypertension (AH) complicated and non-complicated by the metabolic syndrome (MS). Although the changes of interrelation between the proteins of erythrocyte membrane at the AH can influence the deformability of the membrane itself. The aim of the work was to estimate the peculiarities of interrelation between the proteins of erythrocyte membrane in the patients with arterial hypertension complicated and non-complicated by the metabolic syndrome. The research included 51 men with AH and 29 clinically healthy men which were divided into 3 groups: group 1 - control; group 2 - men with AH complicated with MS (n = 29); group 3 - men with AH non-complicated with MS (n = 22). We studied blood lipids, biochemical and hemostasiological parameters, assessed 10 proteins of erythrocyte membrane. Patients of the 2nd and 3rd groups had different content of α- and β-spectrins, anion-transport protein (ATP), plates 4.1, glycerol-3-phosphatededehydrogenase (G-3-PDG), glutathione S-transferase (GST). The results of the research showed that metabolic syndrome at the AH can not only influence the state of vessel wall but also cause significant disorders of structural and functional qualities of the erythrocyte membrane

Level of membrane-bound hemoglobin and red-cell membrane proteins in patients with essential hypertension complicated and not complicated with metabolic syndrome

We studied the effect of different levels of membrane-bound hemoglobin on the level of red-cell membrane proteins and also their interrelation in patients with essential hypertension with and without metabolic syndrome. It wasfound that high membrane-bound hemoglobin is closely related to the low level of high-density lipoproteins and high level of low-density lipoproteins in patients with essential hypertension complicated with metabolic syndrome. In patients with essential hypertension not complicated with metabolic syndrome high membrane-bound hemoglobin is related to the increased prothrombin time and decreased blood urea nitrogen. In patients with essential hypertension complicated with metabolic syndrome high membrane-bound hemoglobin significantly influences the level of membrane contractile proteins (actin, tropomiosine). In patients with essential hypertension without metabolic syndrome high membrane-bound hemoglobin is accompanied by the decrease of structural and integral membrane proteins levels (anion-transport protein and protein 4.1). As the result of quantitative changes in these proteins and change in their interrelations in patients with ssential hypertension complicated with metabolic syndrome more intensive disorders of structural and functional organization of red-cell membrane can appear

Оценка тяжести и клинические маркеры обструктивных нарушений дыхания во время сна

The methods of variation statistics (discriminant, cluster, factor, correlation and regression analyses) were used to determine: 1) the optimal gradation of apnea/hypopnea index (AHI) in order to detect the severity of obstructive sleep disordered breathing (OSDB) and 2) the most representative OSDB clinical markers. Clinical features of OSDB and parameters of nocturnal cardiorespiratory monitoring were analysed in 115 patients of cardiological inpatient department (80 men, 35 women aged 54.6±10.8 years). During nocturnal cardiorespiratory monitoring OSDB with average AHI 23.0±19.4/h was revealed in 105 (91.3%) patients.The results show that the optimal determination of sleep apnea-hypopnea syndrome severity includes the following gradation of AHI: mild - from 5 to 20/hr. moderate — from 20 to 40/hr, severe — >40/hr. To avoid clinical errors it is also necessary in some cases to take into account the duration of apnea/hypopnea events, index of arousal and desaturation degree. The most significant OSDB clinical markers with AHI>5/hr include snore (sensitivity 88%, specificity 100%), BMI>30kg/m2 (80% and 90% respectively) and rates higher than 5 according to the Epworth sleepiness scale (65% and 77% respectively). Risk for OSDB increases rapidly at BMI>25kg/m2 and sleepiness rate >5 according to Epworth scale. BMI>37kg/m2 and sleeping rate >10 according to Epworth scale were often associated with severe (AHI>40/hr) sleep apnea/hypopnea syndrome.Методы вариационной статистики (дискриминантный, кластерный, факторный и корреляционнорегрессионный анализ) использованы для выбора оптимальной градации индекса апноэ/гипопноэ (ИАГ) при оценке степени тяжести обструктивных нарушений дыхания во время сна (ОНДС) и для определения наиболее информативных клинических маркеров ОНДС. Проанализированы клинические проявления и показатели ночного кардиореспираторного мониторирования у 115 пациентов кардиологического стационара (80 мужчин, 35 женщин, средний возраст 54,6±10,8 года). При кардиореспираторном мониторировании ОНДС (средний ИАГ 23,0±19,4/час) были выявлены у 105 (91,3%) пациентов.Результаты исследований показали, что для классификации выраженности синдрома обструктивного апноэ/гипопноэ сна наиболее оптимально использовать следующую градацию ИАГ: легкая степень — от 5 до 20/час, средняя — от 20 до 40/час, тяжелая — более 40/час. Чтобы избежать клинических ошибок, в ряде случаев следует также принимать во внимание продолжительность эпизодов апноэ/гипопноэ, индекс реакций ЭЭГ активации и степень десатурации. Наиболее значимыми клиническими маркерами ОНДС при ИАГ>5/час являются храп (чувствительность 88%, специфичность 100%), индекс массы тела (ИМТ) более 30 кг/м2 (80% и 90% соответственно) и дневная сонливость (ДС) более 5 баллов по шкале Ерworth (65% и 77% соответственно). Риск наличия ОНДС нарастает при ИМТ>25 кг/м2 и ДС>5 баллов по шкале Ерworth при этом значения ИМТ>37 кг/м2 и ДС>10 баллов обычно сопровождаются тяжелым синдромом апноэ/гипопноэ сна с ИАГ>40/час

Neurotoxic complications of chemotherapy in children: posterior reversible encephalopathy syndrome

The aim of the study was to present the clinical-radiological aspect of the syndrome of posterior reversible encephalopathy in children with oncological diseasesЦель публикации — представить клинико-радиологическую картину обратимой энцефалопатии у детей с онкологическими заболеваниям