Neurological soft signs as an endophenotype in an African schizophrenia population – a pilot study

Objective: The use of endophenotypes, such as neurological soft signs (NSS), is advocated as one possible method to elucidate the heterogeneity of schizophrenia. Exploring the associations between NSS and specific illness symptoms has revealed some trends, although results have been conflicting. To date, such studies have been conducted largely on Caucasian populations and our pilot study represents the first attempt to gather such data in a homogenous African population. Method: Fifty-one patients, all of Xhosa ethnicity and participating in a larger schizophrenia genetic study were recruited. NSS were evaluated using a modified Neurological Evaluation Scale. Data were analysed using SPSS with the strength of the overall relationships between NES groups and SANS and SAPS components analyzed by means of canonical correlation analysis. Results: The canonical correlation of SANS domains (excluding asociality) with the NES conceptual groups was 0.53 (SE=0.11, p=0.024) and of the SAPS domains 0.38 (SE=0.13, p=0.943). Conclusion: Our results suggest a correlation between negative symptoms of schizophrenia and the presence of NSS, supporting the recruitment of a larger sample to more comprehensively evaluate a possible role for NSS as an endophenotype in the Xhosa schizophrenia population. Taking into account that NSS evaluations allow for inexpensive, relatively easy-to-do objective evaluations, this method presents us with a valuable research tool that can be used effectively within our under-resourced environment to help inform on the neurobiological substrate of schizophrenia.Keywords: Schizophrenia; Endophenotype; Neurological Soft Sign

Compressive Behaviour of Confined Polycrystalline Ice

NRC publication: Ye

Knowledge and perceptions of nursing staff on the new Road to Health Booklet growth charts in primary healthcare clinics in the Tygerberg subdistrict of the Cape Town metropole district

Objectives: The objectives of the study were to assess the perceptions of nursing staff on the Road to Health Booklet (RTHB), to assess their knowledge of the RTHB growth charts, and to determine whether the level of knowledge was acceptable for successful utilisation of the RTHB growth charts.Design: A cross-sectional descriptive survey.Setting: Twelve primary healthcare clinics in the Tygerberg subdistrict.Subjects: Nursing staff who were going to work with the RTHB on a daily basis.Outcomes measures: The knowledge and perceptions of the nursing staff on the new RTHB were measured using a self-administered questionnaire.Results: The study highlighted that the majority of the nursing staff did not possess sufficient knowledge to successfully utilise the RTHB. The mean score percentage for the total 12 knowledge questions was 55%. Less than a third (n = 13) of participants could correctly interpret the cut-off value for mid-upper-arm circumference. Only 38% and 52% correctly knew that -2 standard deviation for weight-for-age and weight-for-length represents underweight and wasting, respectively. Fifty-five per cent could correctly interpret the growth faltering graph. Forty-three per cent of participants felt the change to the RTHB was unnecessary, and 55% thought that mothers or caregivers would not easily understand the RTHB. More than half (n = 22) of the participants said that they had adequate knowledge to work with the RTHB, while the rest reported that they did not.Conclusion: The RTHB has the potential to decrease the prevalence of malnutrition in children. However, to achieve this, effective usage and understanding of the RTHB is critical.Keywords: Road to Health booklet, growth monitoring, primary healthcare clinics, knowledg

Underrecognition and undertreatment of asthma in Cape Town primary school children

Background. In view of the high local prevalence of asthma, the extent of recognition and appropriate managementof childhood asthma was studied in a large suburban area of Cape Town.Design. Cross-sectional study based on random community sample of schools.Method. 1955 parents of sub B pupils from 16 schools completed a questionnaire, followed by: (f) an interview of parents of 348 symptomatic children; and (if) bronchial responsiveness testing on 254 children. the final case group consisted of 242 children with reported asthma or multiple asthma symptoms on both questionnaires. Children in whom asthma was acknowledged were compared with those in whom it was not.Results. Overall, any past or current ('ever') asthma was acknowledged by respondents in only 53% of the children, and current asthma in only 37.1%. While most children had received treatment in the previous 12 months, 66.1% of therecognised group were on current treatment (23.2% on daily treatment), compared with 37% of the unrecognised group (3% daily). Salbutamol and theophylline syrups were the most common types of medication, while inhalers and antiinflammatory medications were underused. Only a minority of parents reported the child ever having used a peak flow meter, or volunteered knowledge of preventive measures. Current treatment, and to a lesser degree recognition of asthma by parents, were more common among children on medical aid and of higher socio-eonomic status.Conclusions. These findings suggest that ways need to be found: (i) to increase the use of current asthma treatment guidelines by practitioners; (ii) to provide access to comprehensive care by children not on medical aid; and (iii) to improve education of parents in home management measures such as severity assessment and avoidance of smoking, allergen and dietary triggers

Toxic Prisons? Local Environmental Quality and the Wellbeing of Incarcerated Populations

A growing body of scholarship draws attention to prisons and environmental justice, pointing out the propensity for prisons to be located on contaminated sites and to be in close proximity to polluting industries, as well as for prisons themselves to contribute to local environmental degradation. Prisoners’ immobility renders them unable to relocate away from harmful environments, and there are now numerous suggestions that their wellbeing suffers as a result of the poor quality of many local environments. However, since a relationship between environmental quality and prisoner wellbeing is yet to be robustly demonstrated, there is currently no firm evidence base from which to argue for positive change. This paper therefore examines the effect of the environmental quality of the locations of prisons, approximated as the presence of greenspace in the immediate vicinity of prisons, local species biodiversity and local levels of air and noise pollution, on wellbeing outcomes in a set of prisons in England and Wales. It finds that good environmental quality, in the form of high biodiversity and/or low air pollution, enhances the already-recognized positive effects of greenspace on the wellbeing of incarcerated populations. On the basis of these findings, this paper makes evidence-based policy recommendations intended to enhance the wellbeing of incarcerated populations

Greenspace in prison improves well-being irrespective of prison/er characteristics, with particularly beneficial effects for younger and unsentenced prisoners, and in overcrowded prisons

In this paper, we present evidence of estimated significant associations between greenspace and prisoners’ self-reported well-being, self-harm and violence in prisons in England and Wales. Refining and extending our previous research that estimated the relationship between greenspace and self-harm and violence while controlling for the effects of prison characteristics (e.g. prison size, over-crowding and security level), the findings in the present study show that greenspace remains significantly related to self-harm and violence when we additionally control for prison population characteristics (such as prisoner age, ethnicity, sentence length) and when we use additional self-reported indicators of well-being. Furthermore, our findings also show that the beneficial effects of greenspace appear to be particularly prominent in prison establishments that suffer from overcrowding or hold relatively large shares of younger and un-sentenced prisoners. Finally, our results reveal that greenspace has important impacts on the inter-relationships between self-reported well-being, self-harm and prison violence

Evaluation of two nano-silane-modified emulsion stabilised pavements using accelerated pavement testing

Upgrading, maintenance and rehabilitation of road infrastructure is expensive, especially in view of the growing scarcity and cost of suitable road building materials. In areas with high mica content and secondary minerals such as smectite in the natural materials, stabilisation with cement is not viable. The Council for Scientific and Industrial Research of South Africa has embarked on a research programme to evaluate the performance of substandard materials improved with anionic nano-silane modified bitumen emulsions for use in base and subbase layers. This work comprises laboratory testing as well as Accelerated Pavement Testing using the Heavy Vehicle Simulator (HVS). The results of a full-scale HVS test on a light pavement as well as initial analysis on a medium traffic road are discussed. It has been shown that stabilisation of available substandard materials using an anionic nano-silane modified bitumen emulsion compared with the standard approach of importing high quality crushed aggregate can lead to savings as high as 40%–50% for equivalent performance. In addition, there was also a significant reduction in construction effort and time.The Gauteng Department of Roads and Transport.https://www.tandfonline.com/loi/gpav20hj2023Civil Engineerin

The economic cost of air pollution in Mangaung metro municipality: A case study in South Africa

Economic and domestic activities have been causing a profound deterioration of air quality in developed and developing countries. The health problems arising from air pollution have become apparent which result in welfare losses in society such as increased workdays lost and high health cost. This study shows the mitigating cost and workdays lost as a result air pollution related illness and the factors influencing these economic parameters (mitigating cost and workdays lost). Our results demonstrate the economic impact of air pollution which will provide information that could be used to know the significance of air quality, to value the benefits of air pollution control programs, social benefits (in terms of government subsidising clean energy source), policies or strategies to ensure a safe and acceptable air standard to minimise health effects

Does prison location matter for prisoner wellbeing?: The effect of surrounding greenspace on self-harm and violence in prisons in England and Wales

Research on prison location primarily focuses on relationships with local communities and the impact of distance on visitation. Considering the issue of prison location in a different manner, this paper deploys GIS methodology to determine whether the characteristics of prison location can impact prisoners themselves. The presence of greenspace, blue space and major roads in a 500m buffer zone surrounding prisons in England and Wales was calculated using Geographical Information Systems (GIS). An econometric analysis was then undertaken examining this location data in relation to official statistics on violence and self-harm at the institutional level. Econometric estimations confirmed that there are lower levels of self-harm and violence in prisons with higher percentages of greenspace in the buffer zone. These relationships are statistically robust, and they persist when we control for prison size, type, age, and level of crowding. The findings suggest that prisoners may be influenced by the characteristics of prison sites, and that accordingly, these characteristics should be considered when locations for future prisons are selected. Based on these initial findings, we outline the potential for future research to further examine the effect of environmental features on individuals to whom they are not visible