Effect of a posture correction�based intervention on musculoskeletal symptoms and fatigue among control room operators

This study was conducted to examine the effect of a posture correction�based intervention (with a biofeedback device) on the occurrence of musculoskeletal symptoms (MSS) and fatigue among control room operators in a petrochemical plant in Iran. A total of 188 office workers (91 in the case group and 97 in the control group) participated at baseline as well as at 6- and 12-month follow-up. A questionnaire survey (including the Nordic Musculoskeletal Questionnaire and Multidimensional Fatigue Inventory) and direct observations of working postures by using the Rapid Upper Limb Assessment (RULA) method were used. The occurrence of MSS in the shoulders, upper back, neck, and low back areas, as well as the mental and physical dimensions of fatigue were found to be the most common problems. The results showed considerable improvements in working postures (in the neck, trunk, and RULA grand scores) and the occurrence of MSS (particularly in the neck, shoulders, and upper back and low back areas) and fatigue (in particular the mental and physical aspects) after the intervention. The overall mean RULA grand score for the case group was significantly decreased after the intervention (mean scores of 5.1, 4.4, and 4.6 at pre-intervention, post-intervention 1, and post-intervention 2, respectively). A total of 81 operators (89.0) reported some kind of MSS at baseline, which were reduced to 75 operators (82.4) and 77 operators (84.6) at post-interventions 1 and 2, respectively. Significant differences were also found between the pre- and post-intervention scores for the physical fatigue (mean of 12.19, 10.16, and 9.99 at pre-intervention, post-intervention 1, and post-intervention 2, respectively) and mental fatigue (mean of 14.03, 12.05, and 12.16 at pre-intervention, post-intervention 1, and post-intervention 2, respectively) dimensions. The findings confirm the effectiveness of this low-cost, simple, and easy-to-use ergonomic intervention. © 2018 Elsevier Lt

An LES Turbulent Inflow Generator using A Recycling and Rescaling Method

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The present paper describes a recycling and rescaling method for generating turbulent inflow conditions for Large Eddy Simulation. The method is first validated by simulating a turbulent boundary layer and a turbulent mixing layer. It is demonstrated that, with input specification of mean velocities and turbulence rms levels (normal stresses) only, it can produce realistic and self-consistent turbulence structures. Comparison of shear stress and integral length scale indicates the success of the method in generating turbulent 1-point and 2-point correlations not specified in the input data. With the turbulent inlet conditions generated by this method, the growth rate of the turbulent boundary/mixing layer is properly predicted. Furthermore, the method can be used for the more complex inlet boundary flow types commonly found in industrial applications, which is demonstrated by generating non-equilibrium turbulent inflow and spanwise inhomogeneous inflow. As a final illustration of the benefits brought by this approach, a droplet-laden mixing layer is simulated. The dispersion of droplets in the near-field immediately downstream of the splitter plate trailing edge where the turbulent mixing layer begins is accurately reproduced due to the realistic turbulent structures captured by the recycling/rescaling method

Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver

Dysfunction of cell-cell tight junction (TJ) adhesions is a major feature in the pathogenesis of various diseases. Liver TJs preserve cellular polarity by delimiting functional bile-canalicular structures, forming the blood-biliary barrier. In acetaminophen-hepatotoxicity, the mechanism by which tissue cohesion and polarity are affected remains unclear. Here, we demonstrate that acetaminophen, even at low-dose, disrupts the integrity of TJ and cell-matrix adhesions, with indicators of cellular stress with liver injury in the human hepatic HepaRG cell line, and primary hepatocytes. In mouse liver, at human-equivalence (therapeutic) doses, dose-dependent loss of intercellular hepatic TJ-associated ZO-1 protein expression was evident with progressive clinical signs of liver injury. Temporal, dose-dependent and specific disruption of the TJ-associated ZO-1 and cytoskeletal-F-actin proteins, correlated with modulation of hepatic ultrastructure. Real-time impedance biosensing verified in vitro early, dose-dependent quantitative decreases in TJ and cell-substrate adhesions. Whereas treatment with NAPQI, the reactive metabolite of acetaminophen, or the PKCα-activator and TJ-disruptor phorbol-12-myristate-13-acetate, similarly reduced TJ integrity, which may implicate oxidative stress and the PKC pathway in TJ destabilization. These findings are relevant to the clinical presentation of acetaminophen-hepatotoxicity and may inform future mechanistic studies to identify specific molecular targets and pathways that may be altered in acetaminophen-induced hepatic depolarization

Methodology for evaluating gloves in relation to the effects on hand performance capabilities: a literature review

The present study was conducted to review the literature on the methods that have been considered appropriate for evaluation of the effects of gloves on different aspects of hand performance, to make recommendations for the testing and assessment of gloves, and to identify where further research is needed to improve the evaluation protocols. Eighty-five papers meeting the criteria for inclusion were reviewed. Many studies show that gloves may have negative effects on manual dexterity, tactile sensitivity, handgrip strength, muscle activity and fatigue and comfort, while further research is needed to determine glove effects on pinch strength, forearm torque strength and range of finger and wrist movements. The review also highlights several methodological issues (including consideration of both task type and duration of glove use by workers, guidance on the selection and allocation of suitable glove(s) for particular tasks/jobs, and glove design features) that need to be considered in future research

A review of the methodology and applications of anthropometry in ergonomics and product design

Anthropometry is a key element of ergonomic studies for addressing the problem of fitting the tasks/products to user characteristics, but there is a gap between anthropometric data and their application for designing ergonomic products and environments. This research was conducted to review the literature on the methodology and applications of anthropometry for the ergonomic design of products and environments and to identify where further research is needed to improve its application and evaluation protocols. One hundred and sixteen papers meeting the inclusion criteria were reviewed. Although a number of anthropometric investigations have been conducted to improve the design of products/environments for different users, further research seems to be necessary, particularly for special groups, such as children, the elderly and people with disabilities. Different anthropometric measurement methods/techniques and fitting criteria are discussed in terms of their applicability for various design applications. This review also highlights methodological issues (sampling considerations and prototype evaluation and testing) that should be considered in future research to ensure the user-centred approach of the design process.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Applied Ergonomics and Desig

Effect of a posture correction�based intervention on musculoskeletal symptoms and fatigue among control room operators

This study was conducted to examine the effect of a posture correction�based intervention (with a biofeedback device) on the occurrence of musculoskeletal symptoms (MSS) and fatigue among control room operators in a petrochemical plant in Iran. A total of 188 office workers (91 in the case group and 97 in the control group) participated at baseline as well as at 6- and 12-month follow-up. A questionnaire survey (including the Nordic Musculoskeletal Questionnaire and Multidimensional Fatigue Inventory) and direct observations of working postures by using the Rapid Upper Limb Assessment (RULA) method were used. The occurrence of MSS in the shoulders, upper back, neck, and low back areas, as well as the mental and physical dimensions of fatigue were found to be the most common problems. The results showed considerable improvements in working postures (in the neck, trunk, and RULA grand scores) and the occurrence of MSS (particularly in the neck, shoulders, and upper back and low back areas) and fatigue (in particular the mental and physical aspects) after the intervention. The overall mean RULA grand score for the case group was significantly decreased after the intervention (mean scores of 5.1, 4.4, and 4.6 at pre-intervention, post-intervention 1, and post-intervention 2, respectively). A total of 81 operators (89.0) reported some kind of MSS at baseline, which were reduced to 75 operators (82.4) and 77 operators (84.6) at post-interventions 1 and 2, respectively. Significant differences were also found between the pre- and post-intervention scores for the physical fatigue (mean of 12.19, 10.16, and 9.99 at pre-intervention, post-intervention 1, and post-intervention 2, respectively) and mental fatigue (mean of 14.03, 12.05, and 12.16 at pre-intervention, post-intervention 1, and post-intervention 2, respectively) dimensions. The findings confirm the effectiveness of this low-cost, simple, and easy-to-use ergonomic intervention. © 2018 Elsevier Lt