Dynamical scaling in Ising and vector spin glasses

We have studied numerically the dynamics of spin glasses with Ising and XY symmetry (gauge glass) in space dimensions 2, 3, and 4. The nonequilibrium spin-glass susceptibility and the nonequilibrium energy per spin of samples of large size L_b are measured as a function of anneal time t_w after a quench to temperatures T. The two observables are compared to the equilibrium spin-glass susceptibility and the equilibrium energy, respectively, measured as functions of temperature T and system size L for a range of system sizes. For any time and temperature a nonequilibrium time-dependent length scale L*(t_w,T) can be defined by comparing equilibrium and nonequilibrium quantities. Our analysis shows that for all systems studied, an "effective dynamical critical exponent" parametrization L*(t_w,T) = A(T) t^(1/z(T)) fits the data well at each temperature within the whole temperature range studied, which extends from well above the critical temperature to near T = 0 for dimension 2, or to well below the critical temperature for the other space dimensions studied. In addition, the data suggest that the dynamical critical exponent z varies smoothly when crossing the transition temperature.Comment: 14 pages, 13 figures, 9 table

Kinetic limitations of cooperativity based drug delivery systems

We study theoretically a novel drug delivery system that utilizes the overexpression of certain proteins in cancerous cells for cell specific chemotherapy. The system consists of dendrimers conjugated with "keys" (ex: folic acid) which "key-lock" bind to particular cell membrane proteins (ex: folate receptor). The increased concentration of "locks" on the surface leads to a longer residence time for the dendrimer and greater incorporation into the cell. Cooperative binding of the nanocomplexes leads to an enhancement of cell specificity. However, both our theory and detailed analysis of in-vitro experiments indicate that the degree of cooperativity is kinetically limited. We demonstrate that cooperativity and hence the specificity to particular cell type can be increased by making the strength of individual bonds weaker, and suggest a particular implementation of this idea. The implications of the work for optimizing the design of drug delivery vehicles are discussed.Comment: 4 pages, 4 figures, v3: minor revision

Rapid Manufacturing of Silicon Carbide Composites

From the earliest days of SFF technology development, a viable technique for the direct manufacture of fully-functional parts has been a major technology goal. While direct metal methods have been demonstrated for a variety of metals including aluminum, steel and titanium, they have not reached wide commercial application due to processing speed, final material properties and surface finish. In this paper the development of an SLS-based rapid manufacturing (RM) platform is reviewed. The core of this platform is a thermosetting binder system for preform parts in contrast to the thermoplastic materials currently available for SLS. The preforms may include metal and/or ceramic powders. A variety of fully functional parts can be prepared from different combinations of materials and post processing steps including binder pyrolysis, free-standing alloy infiltration, room temperature polymer infiltration and machining. The main issues of these steps are reviewed followed by a discussion about the support of RM. This paper is an intermediate report additional materials, applications, process models and product design strategies will be incorporated into the project in the next year.Mechanical Engineerin

Io's radar properties

Arecibo 13 cm wavelength radar observations during 1987-90 have yielded echoes from Io on each of 11 dates. Whereas Voyager imaged parts of the satellite at resolutions of several km and various visible/infrared measurements have probed the surfaces's microscale properties, the radar data yield new information about the nature of the surface at cm to km scales. Our observations provide fairly thorough coverage and reveal significant heterogeneity in Io's radar properties. A figure is given showing sums of echo spectra from 11 dates

Design and standalone characterisation of a capacitively coupled HV-CMOS sensor chip for the CLIC vertex detector

The concept of capacitive coupling between sensors and readout chips is under study for the vertex detector at the proposed high-energy CLIC electron positron collider. The CLICpix Capacitively Coupled Pixel Detector (C3PD) is an active High-Voltage CMOS sensor, designed to be capacitively coupled to the CLICpix2 readout chip. The chip is implemented in a commercial $180$ nm HV-CMOS process and contains a matrix of $128\times128$ square pixels with $25$ $\mu$m pitch. First prototypes have been produced with a standard resistivity of $\sim20$ $\Omega$cm for the substrate and tested in standalone mode. The results show a rise time of $\sim20$ ns, charge gain of $190$ mV/ke$^{-}$ and $\sim40$ e$^{-}$ RMS noise for a power consumption of $4.8$ $\mu$W/pixel. The main design aspects, as well as standalone measurement results, are presented.Comment: 13 pages, 13 figures, 2 tables. Work carried out in the framework of the CLICdp collaboratio