James Perry and the Morning Chronicle 1790-1821.

This thesis is a study of the career of James Perry, editor and proprietor of the Morning Chronicle, from 1790-1821. Based on an examination of the correspondence of whig and radical politicians, and of the files of the morning Chronicle, it illustrates the impact which Perry made on the world of politics and journalism. The main questions discussed are how Perry responded, as a Foxite journalist, to the chief political issues of the day; the extent to which the whigs attempted to influence his editorial policy and the degree to which he reconciled his independence with obedience to their wishes, the difficulties he encountered as the spokesman of an often divided party; his considerable involvement, which was remarkable for a journalist, in party activity and in the social life of whig politicians; and his success as a newspaper proprietor concerned not only with political propaganda, but with conducting a paper which was distinguished for the quality of its miscellaneous features and for its profitability as a business enterprise. There is also some account of the whigs' attempts to gain the support of other newspapers, but they had little success in this field. The structure of the thesis is chronological, with the exception of chapter four which contains an account of Perry's advertising policy, and illustrates for the first time the amount and importance of a newspaper proprietor's income fran advertisements. The absence of any collection of Perry papers has precluded a study of the internal management of the Chronicle, but it is shown that from a political point of view Perry enjoyed, despite increasing criticism of him after about 1807, a position as the whigs' leading journalist for over thirty years, and that he exercised great moral influence in raising the character of the press

Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry

Staying in touch in the digital era: New social work practice

The findings of a small-scale empirical study are drawn upon to explore the concept of social presence and the way in which it can contribute to meeting service users’ expectations of relationship-based social work. Findings from the study highlight the role of mobile communication technologies in establishing social presence with service users and an argument is made for the proactive use of mobile devices as a component of direct practice. However, such emerging digital social work practices will require practitioners, and social work organisations, to respond positively to new ethical and organisational challenges

Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments.

Stable isotope labeling is the state of the art technique for in vivo quantification of lymphocyte kinetics in humans. It has been central to a number of seminal studies, particularly in the context of HIV-1 and leukemia. However, there is a significant discrepancy between lymphocyte proliferation rates estimated in different studies. Notably, deuterated (2)H2-glucose (D2-glucose) labeling studies consistently yield higher estimates of proliferation than deuterated water (D2O) labeling studies. This hampers our understanding of immune function and undermines our confidence in this important technique. Whether these differences are caused by fundamental biochemical differences between the two compounds and/or by methodological differences in the studies is unknown. D2-glucose and D2O labeling experiments have never been performed by the same group under the same experimental conditions; consequently a direct comparison of these two techniques has not been possible. We sought to address this problem. We performed both in vitro and murine in vivo labeling experiments using identical protocols with both D2-glucose and D2O. This showed that intrinsic differences between the two compounds do not cause differences in the proliferation rate estimates, but that estimates made using D2-glucose in vivo were susceptible to difficulties in normalization due to highly variable blood glucose enrichment. Analysis of three published human studies made using D2-glucose and D2O confirmed this problem, particularly in the case of short term D2-glucose labeling. Correcting for these inaccuracies in normalization decreased proliferation rate estimates made using D2-glucose and slightly increased estimates made using D2O; thus bringing the estimates from the two methods significantly closer and highlighting the importance of reliable normalization when using this technique