Studies on Buddleja asiatica antibacterial, antifungal, antispasmodic and Ca++ antagonist activities

Crude extract of Buddleja asiatica Lour and its fractions, chloroform (F1), ethyl acetate (F2) and nbutanol (F3) were evaluated for antibacterial, antifungal, antispasmodic and Ca++ antagonist activities. The antibacterial activity was performed against 11 types of bacteria. The crude extract and fractions F2 and F3 exhibited significant activity, while F1 showed low activity in killing the Shigella flexenari, Sternostoma boydi and Escherichia coli. In the rest bacteria, the crude extract and all the fractions (F1 to F3) revealed minimum to nil inhibitory effect. The fungicidal activity of the crude extract and all the fractions (F1 to F3) was also performed against six different fungi. The crude extract and fractions F1 and F3 displayed significant activity, while fraction F2 showed moderate activity against Fusarium solani. In the case of Microsporum canis, the crude extract and fraction F3 showed high activity but in the other four fungi, the inhibition area exhibited optimum to nil activity in crude extract and all the fractions (F1 to F3). In isolated rabbit jejunum preparations, B. asiatica crude extract caused concentration-dependent (0.03 to 1.0 mg/ml) relaxation of spontaneous and high K+ (80 mM)-induced contractions. The results indicate the antibacterial, antifungal, antispasmodic and Ca++ antagonist potential of B. asiatica Lour.Key words: Buddleja asiatica, antibacterial, antifungal, antispasmodic, Ca++ channel blocker

Schiff Bases and Their Metallic Derivatives: Highly Versatile Molecules with Biological and Abiological Perspective

1998 onwards, a span reporting thousands of research articles describes the ever-increasing applicability of Schiff bases and their metallic complexes; this chapter comprehensively examines the literature of the last 20 years. The structural diversity of these molecules made them available for a very wide range of biological and abiological applications. Schiff bases are excellent chelators and due to this unique property have found their place in qualitative and quantitative determination of metals in aqueous media. The structural diversity of metal chelates proved these to be outstanding catalysts and displayed interesting fluorescence effect. Finally, Schiff base moieties have found a unique position during the in vitro and in vivo experiments for drug development against a huge number of biological entities including bacteria, fungi, cancer cells, viruses, parasites, etc

The epidemiology of stroke In a developing country (Pakistan)

Ischemic stroke is a major cause of neurological morbidity and mortality. The objective of this review article is to summarize facts pertaining to acute ischemic stroke and its various aspects in a developing country like Pakistan, where resources are limited and the healthcare system is underdeveloped. No large-scale epidemiological studies are available to determine the true incidence of stroke in Pakistan. We conducted a study to determine the prevalence of several important stroke risk factors among Pakistani stroke patients, and to determine whether these risk factors differ among urban versus rural populations. We also used existing data from literature to compare overall stroke incidence in Pakistan to that in developed countries. In this study we found that for stroke besides hypertension, prolonged contraceptive use and pregnancy are additional risk factors in Pakistan. Which is more prevalent in urban populations than rural population? Developed countries except Germany have much lower stroke incidences than Pakistan

HAEMATOLOGICAL AND PLASMA PROTEIN PROFILE IN FAYOUMI HEN SUFFERING FROM ASCITES

A 9 months old Fayumi layer, having 2.5 kg body weight with distended abdomen was examined. On physical examination, the hen was found anaemic, dyspnoeic and recumbent with pulpy abdomen distended with fluid. Upon aspiration, about 800 ml of straw-coloured fluid was collected which contained proteinitious casts but no fibrin. Haematological examination revealed that RBC counts, haematocrit and WBC counts were 3.5 x 1012/L, 25% and 50 x 109/L, respectively. Differential leukocytic counts revealed that heterophils, lymphocytes, monocytes and eosinophils were 50, 26, 18 and 6%, respectively, without any basophils. The concentrations of plasma proteins and fibrinogen were 7.9 g/dL and 312 mg/dL, respectively. The hen was given supportive therapy along with antibiotics and flusher

New furocarbazole alkaloids from Lonicera quinquelocularis

Two new furocarbazole alkaloids, 3-formyl-6,7-dimethoxy-furo[1,2]carbazole (1) and methyl-6,7-dimethoxy-furo[1,2]carbazole-3-carboxylate (2), along with two known carbazole alkaloids, 3-formyl-2-hydroxy-7-methoxycarbazole (3) and methyl 2,7-dimethoxycarbazole-3-carboxylate (4) were isolated from the ethyl acetate soluble fraction of Lonicera quinquelocularis. Their structures were established on the basis of spectroscopic analysis

Negative index fishnet with nanopillars formed by direct nano-imprint lithography

In this paper we demonstrate the ability to fabricate fishnets by nanoimprinting directly into a pre-deposited three layer metal–dielectric–metal stack, enabling us to pattern large areas in two minutes. We have designed and fabricated two different fishnet structures of varying dimensions using this method and measured their resonant wavelengths in the near-infrared at 1.45 μm and 1.88 μm. An important by-product of directly imprinting into the metal–dielectric stack, without separation from the substrate, is the formation of rectangular nanopillars that sit within the rectangular apertures between the fishnet slabs. Simulations complement our measurements and suggest a negative refractive index real part with a magnitude of 1.6. Further simulations suggest that if the fishnet were to be detached from the supporting substrate a refractive index real part of 5 and FOM of 2.74 could be obtained

O(αsa)O(\alpha_{s}a) matching coefficients for axial vector current and ΔB\Delta B==2 operator

We present a calculation of the perturbative matching coefficients including mixing with higher dimensional operators for the temporal component of the heavy-light axial current, $A_{4}$, and the $\Delta B=2$ operator, $O_S$. For $A_{4}^{\scriptsize static, NRQCD}$, calculations with various RG-improved gauge actions are peformed. Matching coefficients with NRQCD and heavy-clover actions are also compared.Comment: LATTICE99 (Heavy Quarks), 3 pages, 2 figures, espcrc2.st

Two flavors of dynamical quarks on anisotropic lattices

We report on our study of two-flavor full QCD on anisotropic lattices using $O(a)$-improved Wilson quarks coupled with an RG-improved glue. The bare gauge and quark anisotropies corresponding to the renormalized anisotropy $\xi=a_s/a_t = 2$ are determined as functions of $\beta$ and $\kappa$, which covers the region of spatial lattice spacings $a_s\approx 0.28$--0.16 fm and $m_{PS}/m_V\approx 0.6$--0.9. The calibrations of the bare anisotropies are performed with the Wilson loop and the meson dispersion relation at 4 lattice cutoffs and 5--6 quark masses. Using the calibration results we calculate the meson mass spectrum and the Sommer scale $r_0$. We confirm that the values of $r_0$ calculated for the calibration using pseudo scalar and vector meson energy momentum dispersion relation coincide in the continuum limit within errors. This work serves to lay ground toward studies of heavy quark systems and thermodynamics of QCD including the extraction of the equation of state in the continuum limit using Wilson-type quark actions.Comment: 16 pages, 23 figures, Version accepted for publication in Physical Review