Albert Cohen

Honorable Mention winner in the Modern Language Association's Aldo and Jeanne Scaglione Prize competition for French and Francophone Literary StudiesA major figure in twentieth-century letters, Albert Cohen (1895–1981) left a paradoxical legacy. His heavily autobiographical, strikingly literary, and polyphonic novels and lyrical essays are widely read by a devout public in France, yet have been largely ignored by academia. A self-consciously Jewish writer and activist, Cohen remained nevertheless ambivalent about Judaism. His self-affirmation as a Jew in juxtaposition with his satirical use of anti-Semitic stereotypes still provokes unease in both republican France and institutional Judaism.In Albert Cohen: Dissonant Voices, the first English-language study of this profound and profoundly misunderstood writer, Jack I. Abecassis traces the recurrent themes of Cohen's works. He reveals the dissonant fractures marking Cohen as a modernist, and analyzes the resistance to his work as a symptom of the will not to understand Cohen's main theme—"the catastrophe of being Jewish."For Abecassis, Cohen's diverse oeuvre forms a single "roman fleuve" exploring this perturbing theme through fragmentation and grotesquerie, fantasies and nightmares, the veiling and unveiling of the unspeakable.Abecassis argues that Cohen should not be read exclusively through the prism of European literature (Stendhal, Tolstoy, Proust), but rather as the retelling—inverting and ultimately exhausting, in the form of submerged plots—of the Biblical romances of Joseph and Esther. The romance of the charismatic Court Jew and its performance correlative, the carnival of Purim, generate the logic of Cohen's acute psychological ambivalence, historical consciousness and carnal sensuality—themes which link this modernist author to Genesis as well as to the literary practices of Sephardic crypto-Jews. Abecassis argues that Cohen's best-known work, Belle du Seigneur (1968), besides being an obvious tale of obsessive love and dissolution, is foremost a tale of political intrigue involving Solal, the meteoric-rising Jew in the League of Nations during the period of Appeasement (1936), and his ultimate self-destruction. Providing close readings and imaginative analyses of the entire literary output of one of twentieth-century France's most important Jewish writers, Abecassis presents here a major work of literary scholarship, as well as a broader study of the reception and influence of Jewish thought in French literature and philosophy

Techniques to improve technological and sanitary quality

Agronomical ways for better quality and safety Choice of cultivar is an efficient way to obtain higher grain quality. Intercropping legumes (grain or forage) improves weed competition and N availability for wheat crop or succeeding crop. Green manure can be an effective alternative to farmyard manure. Fertilization with readily available nitrogen improves yield and quality when water is available. Reduced tillage affects soil fertility and wheat yield but has little effects on grain quality. Technological ways for better quality and safety Milling process strongly influences flour characteristics. Stone milling improves nutritive value; characteristics remain very stable independent of the milling yield. Flour characteristics from roller milling appear very susceptible to the milling yield. Increasing the milling yield in the aim of enriching nutritional quality has a detrimental effect either on safety (DON) or on bread-making quality (bread volume)

Technological quality of organic wheat in Europe

The demand for high quality organic bread wheat is increasing. The quality level of organic wheat harvested in EU is mainly dependant on variety, environmental conditions and agronomic practices. In some countries, protein content and composition, influencing technological value, are equivalent to those produced under conventional practices. Beside agronomical techniques, technological processes can help to maintain a good quality. Pre-treatments before milling such as debranning were found to be efficient in reducing DON contamination. The project highlighted the necessity to redefine the methods to assess the quality of organic wheat

Improving baking quality, nutritional value and safety of organic winter wheat / Améliorer la qualité technologique, nutritionnelle et sanitaire du blé biologique, Principaux leviers agronomiques et technologiques

The organic bread wheat market has been diversified over time through the emergence of different sale channels. Processors require organic bread wheat of higher quality and safety in order to meet the consumers’ demand. The overall objective of the AGTEC-Org project was to identify agronomical and technological ways to improve the performance of organic wheat and flour. The findings would contribute to enhanced baking quality and nutritional value of organic flour, as well as prevention of mycotoxin contamination. The project involved 9 research centers or universities from 5 European countries for a total budget of about 1.5 million €. More than 400 experimental treatments were analyzed from 23 agronomic trials and 4 lab-experiments on food technology. Choice of cultivar is an efficient way to obtain higher grain quality. Intercropping legumes (grain or forage) improves weed control and N availability for wheat crop or succeeding crop. Green manure can be an effective alternative to farmyard manure. Fertilization with organic fertilizers improves yield and quality when water is available. Reduced tillage affects soil fertility and wheat yield but has little effects on grain quality. Milling process strongly influences flour characteristics. Stone milling improves the nutritive value and flour characteristics remain very stable independently of the milling yield. However, stone milling slightly raises DON levels. Characteristics of flour produced by means of roller milling appear very dependent on milling yield, instead. Increasing milling yield with the aim of enriching nutritional quality has a detrimental effect on either safety (DON) or bread-making quality (bread volume). Debranning before milling has a very positive impact on flour safety by reducing its DON content by 50 %

Liver and Intestine Transplantation in the United States, 1995–2004

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74804/1/j.1600-6143.2006.01273.x.pd

Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long‐Term Outcomes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/122411/1/ajt13728.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122411/2/ajt13728-sup-0005-AppendixS5.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122411/3/ajt13728-sup-0003-AppendixS3.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122411/4/ajt13728_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/122411/5/ajt13728-sup-0004-AppendixS4.pd

Characterization of surface Ag nanoparticles in nanocomposite a-C:Ag coatings by grazing incidence X-ray diffraction at sub-critical angles of incidence

Silver diffusion within nanocomposite films and/or toward the film surface is often observed during annealing of the silver-based nanocomposite films. In order to control and/or minimize this process, it is crucial to characterize the aggregated silver nanoparticles on the films surface. In this paper grazing incidence X-ray diffraction (GIXRD) with both sub-critical and supra-critical angles of incidence is used to characterize the Ag nanoparticles distribution, shape and structure both inside the matrix and on the nanocomposite film surface. The nanocomposite carbon coating containing Ag nanoparticles (a-C:Ag) was deposited by dc magnetron sputtering. The coatings were analyzed by GIXRD using fixed incident angles both below and above the critical angle for total reflection. By using sub-critical angles it was possible to eliminate diffraction from the bulk material allowing to estimate the size distribution of the nanoparticles sitting on the surface. The results obtained by GIXRD analysis were checked through comparison with the observations made by both TEM and SEM analysis. The proposed methodology can be used to characterized nanoparticles deposition on a surface and/or island formation during film growth as long an adequate substrate with high critical angle for total reflection is used.We gratefully acknowledge the financial support provided by the FCT—Fundação para a Ciência e Tecnologia and FSE for the grant SFRH/BD/82472/2011. This research is sponsored by the FEDER funds through the program COMPETE—Programa Operacional Factores de Competitividade and by the national funds through FCT—Fundação para a Ciência e Tecnologia in the framework of the Strategic Projects PEST C/EME/UIO0285/2011

Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma

We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25–28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing

Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Blood and Marrow Transplantation (EBMT)

Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children

An entire exon 3 germ-line rearrangement in the BRCA2 gene: pathogenic relevance of exon 3 deletion in breast cancer predisposition

<p>Abstract</p> <p>Background</p> <p>Germ-line mutations in the <it>BRCA1 </it>and <it>BRCA2 </it>genes are major contributors to hereditary breast/ovarian cancer. Large rearrangements are less frequent in the <it>BRCA2 </it>gene than in <it>BRCA1</it>. We report, here, the first total deletion of exon 3 in the <it>BRCA2 </it>gene that was detected during screening of 2058 index cases from breast/ovarian cancer families for <it>BRCA2 </it>large rearrangements. Deletion of exon 3, which is in phase, does not alter the reading frame. Low levels of alternative transcripts lacking exon 3 (Δ3 delta3 transcript) have been reported in normal tissues, which raises the question whether deletion of exon 3 is pathogenic.</p> <p>Methods</p> <p>Large <it>BRCA2 </it>rearrangements were analysed by QMPSF (Quantitative Multiplex PCR of Short Fluorescent Fragments) or MLPA (Multiplex Ligation-Dependent Probe Amplification). The exon 3 deletion was characterized with a "zoom-in" dedicated CGH array to the <it>BRCA2 </it>gene and sequencing. To determine the effect of exon 3 deletion and assess its pathogenic effect, three methods of transcript quantification were used: fragment analysis of FAM-labelled PCR products, specific allelic expression using an intron 2 polymorphism and competitive quantitative RT-PCR.</p> <p>Results</p> <p>Large rearrangements of <it>BRCA2 </it>were detected in six index cases out of 2058 tested (3% of all deleterious <it>BRCA2 </it>mutations). This study reports the first large rearrangement of the <it>BRCA2 </it>gene that includes all of exon 3 and leads to an <it>in frame </it>deletion of exon 3 at the transcriptional level. Thirty five variants in exon 3 and junction regions of <it>BRCA2 </it>are also reported, that contribute to the interpretation of the pathogenicity of the deletion. The quantitative approaches showed that there are three classes of delta3 <it>BRCA2 </it>transcripts (low, moderate and exclusive). Exclusive expression of the delta3 transcript by the mutant allele and segregation data provide evidence for a causal effect of the exon 3 deletion.</p> <p>Conclusion</p> <p>This paper highlights that large rearrangements and total deletion of exon 3 in the <it>BRCA2 </it>gene could contribute to hereditary breast and/or ovarian cancer. In addition, our findings suggest that, to interpret the pathogenic effect of any variants of exon 3, both accurate transcript quantification and co-segregation analysis are required.</p