171 research outputs found
New approaches to model and study social networks
We describe and develop three recent novelties in network research which are
particularly useful for studying social systems. The first one concerns the
discovery of some basic dynamical laws that enable the emergence of the
fundamental features observed in social networks, namely the nontrivial
clustering properties, the existence of positive degree correlations and the
subdivision into communities. To reproduce all these features we describe a
simple model of mobile colliding agents, whose collisions define the
connections between the agents which are the nodes in the underlying network,
and develop some analytical considerations. The second point addresses the
particular feature of clustering and its relationship with global network
measures, namely with the distribution of the size of cycles in the network.
Since in social bipartite networks it is not possible to measure the clustering
from standard procedures, we propose an alternative clustering coefficient that
can be used to extract an improved normalized cycle distribution in any
network. Finally, the third point addresses dynamical processes occurring on
networks, namely when studying the propagation of information in them. In
particular, we focus on the particular features of gossip propagation which
impose some restrictions in the propagation rules. To this end we introduce a
quantity, the spread factor, which measures the average maximal fraction of
nearest neighbors which get in contact with the gossip, and find the striking
result that there is an optimal non-trivial number of friends for which the
spread factor is minimized, decreasing the danger of being gossiped.Comment: 16 Pages, 9 figure
The ecology of methane in streams and rivers: patterns, controls, and global significance
Streams and rivers can substantially modify organic carbon (OC) inputs from terrestrial landscapes, and much of this processing is the result of microbial respiration. While carbon dioxide (COâ) is the major endâproduct of ecosystem respiration, methane (CHâ) is also present in many fluvial environments even though methanogenesis typically requires anoxic conditions that may be scarce in these systems. Given recent recognition of the pervasiveness of this greenhouse gas in streams and rivers, we synthesized existing research and data to identify patterns and drivers of CHâ, knowledge gaps, and research opportunities. This included examining the history of lotic CH4 research, creating a database of concentrations and fluxes (MethDB) to generate a globalâscale estimate of fluvial CHâ efflux, and developing a conceptual framework and using this framework to consider how human activities may modify fluvial CHâ dynamics. Current understanding of CHâ in streams and rivers has been strongly influenced by goals of understanding OC processing and quantifying the contribution of CHâ to ecosystem C fluxes. Less effort has been directed towards investigating processes that dictate in situ CHâ production and loss. CHâ makes a meager contribution to watershed or landscape C budgets, but streams and rivers are often significant CHâ sources to the atmosphere across these same spatial extents. Most fluvial systems are supersaturated with CHâ and we estimate an annual global emission of 26.8 Tg CHâ, equivalent to ~15â40% of wetland and lake effluxes, respectively. Less clear is the role of CHâ oxidation, methanogenesis, and total anaerobic respiration to whole ecosystem production and respiration. Controls on CHâ generation and persistence can be viewed in terms of proximate controls that influence methanogenesis (organic matter, temperature, alternative electron acceptors, nutrients) and distal geomorphic and hydrologic drivers. Multiple controls combined with its extreme redox status and low solubility result in high spatial and temporal variance of CHâ in fluvial environments, which presents a substantial challenge for understanding its largerâscale dynamics. Further understanding of CHâ production and consumption, anaerobic metabolism, and ecosystem energetics in streams and rivers can be achieved through more directed studies and comparison with knowledge from terrestrial, wetland, and aquatic disciplines."Support for this paper was provided by funding from the North Temperate Lakes LTER program, NSF DEBâ0822700."https://esajournals.onlinelibrary.wiley.com/doi/full/10.1890/15-102
TellEat: sharing experiences on the move
In a context where, due to the proliferation of mobile devices, virtual social environments on the Web are taking up a very concrete role in the way people experience their surroundings, the Future Internet seems to be headed toward a mixture of Social Web, Semantic Web and Augmented Reality. As a part of a larger project that aims at building a social network of both people and things, we designed and developed TellEat, an iPhone-based application that allows users in mobility to share facts concerning people or objects that participate in the social network, and to discover pertinent events that have been told by others. In this paper we discuss both the client application, with the interaction model and interface metaphors that have been designed to make the experience as playful as possible for users, and the server-side services that provide the necessary knowledge and reasoning mechanisms. We also present the results of preliminary tests with users
The International Trade Network: weighted network analysis and modelling
Tools of the theory of critical phenomena, namely the scaling analysis and
universality, are argued to be applicable to large complex web-like network
structures. Using a detailed analysis of the real data of the International
Trade Network we argue that the scaled link weight distribution has an
approximate log-normal distribution which remains robust over a period of 53
years. Another universal feature is observed in the power-law growth of the
trade strength with gross domestic product, the exponent being similar for all
countries. Using the 'rich-club' coefficient measure of the weighted networks
it has been shown that the size of the rich-club controlling half of the
world's trade is actually shrinking. While the gravity law is known to describe
well the social interactions in the static networks of population migration,
international trade, etc, here for the first time we studied a non-conservative
dynamical model based on the gravity law which excellently reproduced many
empirical features of the ITN.Comment: 5 pages, 5 figure
Analysis of a large-scale weighted network of one-to-one human communication
We construct a connected network of 3.9 million nodes from mobile phone call
records, which can be regarded as a proxy for the underlying human
communication network at the societal level. We assign two weights on each edge
to reflect the strength of social interaction, which are the aggregate call
duration and the cumulative number of calls placed between the individuals over
a period of 18 weeks. We present a detailed analysis of this weighted network
by examining its degree, strength, and weight distributions, as well as its
topological assortativity and weighted assortativity, clustering and weighted
clustering, together with correlations between these quantities. We give an
account of motif intensity and coherence distributions and compare them to a
randomized reference system. We also use the concept of link overlap to measure
the number of common neighbors any two adjacent nodes have, which serves as a
useful local measure for identifying the interconnectedness of communities. We
report a positive correlation between the overlap and weight of a link, thus
providing strong quantitative evidence for the weak ties hypothesis, a central
concept in social network analysis. The percolation properties of the network
are found to depend on the type and order of removed links, and they can help
understand how the local structure of the network manifests itself at the
global level. We hope that our results will contribute to modeling weighted
large-scale social networks, and believe that the systematic approach followed
here can be adopted to study other weighted networks.Comment: 25 pages, 17 figures, 2 table
Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions
Funding: This work was supported by grants from the Russian Science Foundation (grant # 17-74-20049âsynthesis of C-methylated Spd analogues, ITC studies of dimerization of OAZ1, and frameshifting experiments), the Russian Science Foundation (grant # 19-74-10086âisolation of OAZ1, electrophoresis studies of dimerization of OAZ1), and the Academy of Finland (grants # 292574 and # 315487). Acknowledgments: The authors thank A. Karppinen, A. Korhonen, T. Reponen, M. Salminkoski, and S.D. Negrya for their skillful technical assistance.Peer reviewedPublisher PD
N2O Release from agro-biofuel production negates global warming reduction by replacing fossil fuels
The relationship, on a global basis, between the amount of N fixed by chemical, biological or atmospheric processes entering the terrestrial biosphere, and the total emission of nitrous oxide (N2O), has been re-examined, using known global atmospheric removal rates and concentration growth of N2O as a proxy for overall emissions. For both the pre-industrial period and in recent times, after taking into account the large-scale changes in synthetic N fertiliser production, we find an overall conversion factor of 3â5 % from newly fixed N to N2OâN. We assume the same factor to be valid for biofuel production systems. It is covered only in part by the default conversion factor for âdirectâ emissions from agricultural crop lands (1 %) estimated by IPCC (2006), and the default factors for the âindirectâ emissions (following volalilization/deposition and leaching/runoff of N: 0.35â0.45 %) cited therein. However, as we show in the paper, when additional emissions included in the IPCC methodology, e.g. those from livestock production, are included, the total may not be inconsistent with that given by our âtop-downâ method. When the extra N2O emission from biofuel production is calculated in âCO2-equivalentâ global warming terms, and compared with the quasi-cooling effect of âsavingâ emissions of fossil fuel derived CO2, the outcome is that the production of commonly used biofuels, such as biodiesel from rapeseed and bioethanol from corn (maize), depending on N fertilizer uptake efficiency by the plants, can contribute as much or more to global warming by N2O emissions than cooling by fossil fuel savings. Crops with less N demand, such as grasses and woody coppice species, have more favourable climate impacts. This analysis only considers the conversion of biomass to biofuel. It does not take into account the use of fossil fuel on the farms and for fertilizer and pesticide production, but it also neglects the production of useful co-products. Both factors partially compensate each other. This needs to be analyzed in a full life cycle assessment
Dioctadecyldimethylammonium:monoolein nanocarriers for efficient in vitro gene silencing
This study describes a novel liposomal formulation for siRNA delivery, based on the mixture of the neutral lipid monoolein (MO) and cationic lipids of the dioctadecyldimethylammonium (DODA) family. The cationic lipids dioctadecyldimethylammonium bromide (DODAB) and chloride (DODAC) were compared in order to identify which one will most efficiently induce gene silencing. MO has a fluidizing effect on DODAC and DODAB liposomes, although it was more homogeneously distributed in DODAC bilayers. All MO-based liposomal formulations were able to efficiently encapsulate siRNA. Stable lipoplexes of small size (100-160 nm) with a positive surface charge (>+45 mV) were formed. A more uniform MO incorporation in DODAC:MO may explain an increase of the fusogenic potential of these liposomes. The siRNA-lipoplexes were readily internalized by human nonsmall cell lung carcinoma (H1299) cells, in an energy dependent process. DODAB:MO nanocarriers showed a higher internalization efficiency in comparison to DODAC:MO lipoplexes, and were also more efficient in promoting gene silencing. MO had a similar gene silencing ability as the commonly used helper lipid 1,2-dioleyl-3-phosphatidylethanolamine (DOPE), but with much lower cytotoxicity. Taking in consideration all the results presented, DODAB:MO liposomes are the most promising tested formulation for systemic siRNA delivery.This work was supported by FEDER through POFC - COMPETE and by national funds from FCT through the projects PEst-C/BIA/UI4050/2011 (CBM.A), PEst-C/FIS/UI0607/2011 (CFUM), and PTDC/QUI/69795/2006, while Ana Oliveira holds scholarship SFRH/BD/68588/2010. Eloi Feitosa thanks FAPESP (2011/03566-0) and CNPq (303030/2012-7), and Renata D. Adati thanks FAPESP for scholarship (2011/07414-0). K. Raemdonck is a postdoctoral fellow of the Research Foundation - Flanders (FWO-Vlaanderen). We acknowledge NanoDelivery-I&D em Bionanotecnologia, Lda. for access to their equipment
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