4,110 research outputs found
Glacial cycles drive variations in the production of oceanic crust
Glacial cycles redistribute water between oceans and continents causing
pressure changes in the upper mantle, with consequences for melting of Earth's
interior. Using Plio-Pleistocene sea-level variations as a forcing function,
theoretical models of mid-ocean ridge dynamics that include melt transport
predict temporal variations in crustal thickness of hundreds of meters. New
bathymetry from the Australian-Antarctic ridge shows significant spectral
energy near the Milankovitch periods of 23, 41, and 100 ky, consistent with
model predictions. These results suggest that abyssal hills, one of the most
common bathymetric features on Earth, record the magmatic response to changes
in sea level. The models and data support a link between glacial cycles at the
surface and mantle melting at depth, recorded in the bathymetric fabric of the
sea floor.Comment: 30 pages, 6 figures (including supplementary information).
Resubmitted to Science on 12 December 201
ESR Study of (C_5H_{12}N)_2CuBr_4
ESR studies at 9.27, 95.4, and 289.7 GHz have been performed on
(CHN)CuBr down to 3.7 K. The 9.27 GHz data were acquired
with a single crystal and do not indicate the presence of any structural
transitions. The high frequency data were collected with a polycrystalline
sample and resolved two absorbances, consistent with two crystallographic
orientations of the magnetic sites and with earlier ESR studies performed at
300 K. Below T, our data confirm the presence of a spin singlet
ground state.Comment: 2 pages, 4 figs., submitted 23rd International Conference on Low
Temperature Physics (LT-23), Aug. 200
Microscopic Theory of Rashba Interaction in Magnetic Metal
Theory of Rashba spin-orbit coupling in magnetic metals is worked out from
microscopic Hamiltonian describing d-orbitals. When structural inversion
symmetry is broken, electron hopping between -orbitals generates chiral
ordering of orbital angular momentum, which combines with atomic spin-orbit
coupling to result in the Rashba interaction. Rashba parameter characterizing
the interaction is band-specific, even reversing its sign from band to band.
Large enhancement of the Rashba parameter found in recent experiments is
attributed to the orbital mixing of 3d magnetic atoms with non-magnetic heavy
elements as we demonstrate by first-principles and tight-binding calculations.Comment: 5 pages, 2 figure
Potential for Using Smartphone Accelerometers in Non-laboratory Environments
In recent years, there has been rising interest in using accelerometers as an alternative instrument to measure the center of pressure. Accelerometers are inexpensive, small, sensitive, and can be readily used in non-laboratory environments. In addition to this, smartphones with built-in accelerometers add to their capability with real-time processing of data from sensors. Clinicians and researchers are currently in disagreement from whether these measurements provide the same physiological information about the participant’s balance. In this study, twelve participants were asked to wear smartphone on their right ASIS using a belt clip and stand still on the forceplate. The data was synchronized using a tap by the right foot and collected over a fifty second period for analysis. Various linear and non-linear measures were extracted from the time series of resultant principal component (PC) scores. The results show high correlation in the COP time series from the two instruments (R=0.86)
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Glacial cycles drive variations in the production of oceanic crust
Glacial cycles redistribute water between oceans and continents, causing pressure changes in the upper mantle, with consequences for the melting of Earth’s interior. Using Plio-Pleistocene sea-level variations as a forcing function, theoretical models of mid-ocean ridge dynamics that include melt transport predict temporal variations in crustal thickness of hundreds of meters. New bathymetry from the Australian-Antarctic ridge shows statistically significant spectral energy near the Milankovitch periods of 23, 41, and 100 thousand years, which is consistent with model predictions. These results suggest that abyssal hills, one of the most common bathymetric features on Earth, record the magmatic response to changes in sea level. The models and data support a link between glacial cycles at the surface and mantle melting at depth, recorded in the bathymetric fabric of the sea floor.Earth and Planetary Science
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway.
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ. In response to stimulation, LATS1/2 phosphorylate and inhibit YAP/TAZ, the main effectors of the Hippo pathway. Accumulating evidence suggests that MST1/2 are not required for the regulation of YAP/TAZ. Here we show that deletion of LATS1/2 but not MST1/2 abolishes YAP/TAZ phosphorylation. We have identified MAP4K family members--Drosophila Happyhour homologues MAP4K1/2/3 and Misshapen homologues MAP4K4/6/7-as direct LATS1/2-activating kinases. Combined deletion of MAP4Ks and MST1/2, but neither alone, suppresses phosphorylation of LATS1/2 and YAP/TAZ in response to a wide range of signals. Our results demonstrate that MAP4Ks act in parallel to and are partially redundant with MST1/2 in the regulation of LATS1/2 and YAP/TAZ, and establish MAP4Ks as components of the expanded Hippo pathway
A Soluble Sulfogalactosyl Ceramide Mimic Promotes ΔF508 CFTR Escape from Endoplasmic Reticulum Associated Degradation
SummaryAdaSGC binds Hsc70s to inhibit ATPase activity. Using single-turnover assays, adaSGC, a soluble SGC mimic, preferentially inhibited Hsp40-activated Hsc70 ATP hydrolysis (Ki ∼ 10 μM) to reduce C-terminal Hsc70-peptide binding and, potentially, chaperone function. ERAD of misfolded ΔF508 CFTR requires Hsc70-Hsp40 chaperones. In transfected baby hamster kidney (BHK) cells, adaSGC increased ΔF508CFTR ERAD escape, and after low-temperature glycerol rescue, maturation, and iodide efflux. Inhibition of SGC biosynthesis reduced ΔF508CFTR but not wtCFTR expression, whereas depletion of other glycosphingolipids had no affect. WtCFTR transfected BHK cells showed increased SGC synthesis compared with ΔF508CFTR/mock-transfected cells. Partial rescue of ΔF508CFTR by low-temperature glycerol increased SGC synthesis. AdaSGC also increased cellular endogenous SGC levels. SGC in the lung, liver, and kidney was severely depleted in ΔF508CFTR compared with wtCFTR mice, suggesting a role for CFTR in SGC biosynthesis
Efficient magneto-optical trapping of Yb atoms with a violet laser diode
We report the first efficient trapping of rare-earth Yb atoms with a
high-power violet laser diode (LD). An injection-locked violet LD with a 25 mW
frequency-stabilized output was used for the magneto-optical trapping (MOT) of
fermionic as well as bosonic Yb isotopes. A typical number of
atoms for Yb with a trap density of cm was
obtained. A 10 mW violet external-cavity LD (ECLD) was used for the
one-dimensional (1D) slowing of an effusive Yb atomic beam without a Zeeman
slower resulting in a 35-fold increase in the number of trapped atoms. The
overall characteristics of our compact violet MOT, e.g., the loss time of 1 s,
the loading time of 400 ms, and the cloud temperature of 0.7 mK, are comparable
to those in previously reported violet Yb MOTs, yet with a greatly reduced cost
and complexity of the experiment.Comment: 5 pages, 3 figures, 1 table, Phys. Rev. A (to be published
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