Comparative analysis of nonvolatile and volatile metabolites in <i>Lichtheimia ramosa</i> cultivated in different growth media

<p><i>Lichtheimia ramosa</i> is one of the predominant filamentous fungi in Korean traditional <i>nuruk</i>. The nonvolatile and volatile metabolites of <i>L. ramosa</i> cultivated in three growth media: complete medium (CM), potato dextrose broth (PDB), and sabouraud dextrose broth (SDB), were investigated and compared. Among nonvolatile metabolites, serine, lysine, and ornithine increased in CM and PDB cultivated with <i>L. ramosa</i> during the exponential phase. In addition, glucose level increased in CM whereas decreased in PDB and SDB. The major volatile metabolites in the extract samples were acetic acid, ethanol, 3-methyl-2-buten-1-ol, 2-phenylethanol, ethylacetate, 2-furaldehyde, 5-(hydroxymethyl)-2-furaldehyde, 2,3-dihydro-3,5,-dihydroxy-6-methyl-4<i>H</i>-pyran-4-one, and <i>α</i>-humulene. In particular, the levels of volatile metabolites related to <i>makgeolli</i> (e.g., acetic acid, ethanol, and ethyl acetate) were highest in extracts cultivated in CM. On the other hand, the level of 2-phenylethanol was relatively higher in PDB and SDB, possibly due to there being more phenylalanine present in the biomass sample in media.</p

Additional file 1: of Prevalence and prognostic implications of psychological distress in patients with gastric cancer

Supplementary figure and tables. Disease free survival differences by TNM sub-stage, psychiatric illness by age group. (DOC 109 kb

Additional file 2: of LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

Figure S2. Enriched genes of cancer-related and cell proliferation pathways according to the two histologic types; serous and endometrioid. (PNG 486 kb

Additional file 2: of LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

Figure S2. Enriched genes of cancer-related and cell proliferation pathways according to the two histologic types; serous and endometrioid. (PNG 486 kb

Additional file 1: of LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

Figure S1. Gene set enrichment analysis according to histologic types and TCGA classes. (PNG 144 kb

Additional file 1: Figure S1. of Prognostic implications of PD-L1 expression in patients with soft tissue sarcoma

Survival analyses according to PD-L1 expression in patients with localized disease. (A) Kaplan-Meier survival curves for recurrence-free survival (RFS). (B) Kaplan-Meier survival curves for overall survival (OS). (TIF 84 kb